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Yujia Xu
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: Chinese, English
Protein Modification
Ferroptosis
Anti-Tumor
Small Molecules
Drug Discovery
Cancer Research
Biochemistry
Molecular Biology
Cell Death
Therapeutics
Areas of Focus
- Post-translational modification of proteins
- Ferroptosis
- Discovery of anti-tumor small molecule drugs
Work Experience
- 2022/10-present - Guangzhou Medical University - Professor
- 2020/09-2022/06 - Guangzhou Medical University - Postdoctoral Researcher
Academic Background & Achievements
- 2014/09-2020/06 PhD: Soochow University
- 2010/09-2014/06 Bachelor's: Hubei University of Chinese Medicine
Publications
- Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma., Xu Y, Xu M, Tong J, Tang X, Chen J, Chen X, Zhang Z, Cao B, Moran MF, Wu D*, Mao X*., 2021
- The ubiquitin conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis., Xu Y#, Zhang Z#, Li J#, Tong J, Cao B, Taylor P, Tang X, Wu D, Moran M, Zeng Y*, Mao X*., 2017
- Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf., Yujia Xu#, Tong Sun#, Kun Zeng, Min Xu, Jinhao Chen, Xiaofeng Xu, Zubin Zhang, Biyin Cao, Xiaowen Tang, Depei Wu, Yan Kong, Yuanying Zeng*, Xinliang Mao*., 2020
- Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia., Zhuang H, Ren Y, Mao C, Zhong Y, Zhang Z, Cao B, Zhang Y, Huang J, Xu G, Huang Z, Xu Y*, Mao X*., 2022
- Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis., Tong Sun#, Yujia Xu#, Zhuan Xu#, Biyin Cao, Zubin Zhang, Qi Wang*, Yan Kong*, Xinliang Mao*., 2021
- Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis., Xue-Han Chen#, Yujia Xu#, Xiao-Ge Wang#, Peng Lin, Bi-Yin Cao, Yuan-Ying Zeng, Qi Wang, Zu-Bin Zhang*, Xin-Liang Mao*, Tie Zhang*., 2019
- Novel conjugates of endoperoxide and 4-anilinoquinazoline induce myeloma cell apoptosis by inhibiting the IGF1-R/AKT/mTOR signaling pathway., Xu Y#, Zeng K#, Wang X, Zhang J, Cao B, Zhang Z, Qiao C, Xu X, Wang Q, Zeng Y, Mao X., 2020
- A novel STAT3 inhibitor negatively modulates platelet activation and aggregation., Zhuan Xu#, Yu-Jia Xu#, Ya-Nan Hao#, Li-Jie Ren, Zu-Bin Zhang, Xin Xu, Bi-Yin Cao, Ke-Sheng Dai, Li Zhu, Qi Fang*, Yan Kong*, Xin-Liang Mao*., 2017
