Professor | 徐宇嘉 | 数字化转型顾问

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Name	徐宇嘉
Contact Information	xuyujia@gzhmu.edu.cn
Language ability	中文, 英文
Province	广东

Upload Avatar (500 x 500)

Name

徐宇嘉

Contact Information

xuyujia@gzhmu.edu.cn

Language ability

中文, 英文

Province

广东

University/Lab Affiliation and Title	广州医科大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	2014/09-2020/06 博士: 苏州大学 2010/09-2014/06 学士: 湖北中医药大学
Work Experience	2022/10至今 - 广州医科大学 - 教授 2020/09-2022/06 - 广州医科大学 - 博后

University/Lab Affiliation and Title

广州医科大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

2014/09-2020/06 博士: 苏州大学
2010/09-2014/06 学士: 湖北中医药大学

Work Experience

2022/10至今 - 广州医科大学 - 教授
2020/09-2022/06 - 广州医科大学 - 博后

Areas of Focus	蛋白质翻译后修饰铁死亡抗肿瘤小分子药物的发现
Publications	靶向Otub1/c-Maf轴治疗多发性骨髓瘤。, Xu Y, Xu M, Tong J, Tang X, Chen J, Chen X, Zhang Z, Cao B, Moran MF, Wu D, Mao X., 2021 泛素结合酶UBE2O调节c-Maf稳定性并诱导骨髓瘤细胞凋亡。, Xu Y#, Zhang Z#, Li J#, Tong J, Cao B, Taylor P, Tang X, Wu D, Moran M, Zeng Y, Mao X., 2017 抗菌和抗病毒的南昌霉素通过靶向Otub1和c-Maf显示抗骨髓瘤活性。, Yujia Xu#, Tong Sun#, Kun Zeng, Min Xu, Jinhao Chen, Xiaofeng Xu, Zubin Zhang, Biyin Cao, Xiaowen Tang, Depei Wu, Yan Kong, Yuanying Zeng, Xinliang Mao., 2020 诱导锌指蛋白RNF6自泛素化治疗骨髓瘤和慢性髓性白血病。, Zhuang H, Ren Y, Mao C, Zhong Y, Zhang Z, Cao B, Zhang Y, Huang J, Xu G, Huang Z, Xu Y, Mao X., 2022 草药acevaltrate通过抑制Otub1/c-Maf轴诱导骨髓瘤细胞凋亡。, Tong Sun#, Yujia Xu#, Zhuan Xu#, Biyin Cao, Zubin Zhang, Qi Wang, Yan Kong, Xinliang Mao., 2021 甲苯咪唑通过抑制USP5/c-Maf轴引发强效抗骨髓瘤活性。, Xue-Han Chen#, Yujia Xu#, Xiao-Ge Wang#, Peng Lin, Bi-Yin Cao, Yuan-Ying Zeng, Qi Wang, Zu-Bin Zhang, Xin-Liang Mao, Tie Zhang., 2019 新型内过氧化物和4-苯胺喹唑啉结合物通过抑制IGF1-R/AKT/mTOR信号通路诱导骨髓瘤细胞凋亡。, Xu Y#, Zeng K#, Wang X, Zhang J, Cao B, Zhang Z, Qiao C, Xu X, Wang Q, Zeng Y, Mao X., 2020 一种新型STAT3抑制剂负调节血小板活化和聚集。, Zhuan Xu#, Yu-Jia Xu#, Ya-Nan Hao#, Li-Jie Ren, Zu-Bin Zhang, Xin Xu, Bi-Yin Cao, Ke-Sheng Dai, Li Zhu, Qi Fang, Yan Kong, Xin-Liang Mao*., 2017

Areas of Focus

蛋白质翻译后修饰
铁死亡
抗肿瘤小分子药物的发现

Publications

靶向Otub1/c-Maf轴治疗多发性骨髓瘤。, Xu Y, Xu M, Tong J, Tang X, Chen J, Chen X, Zhang Z, Cao B, Moran MF, Wu D*, Mao X*., 2021
泛素结合酶UBE2O调节c-Maf稳定性并诱导骨髓瘤细胞凋亡。, Xu Y#, Zhang Z#, Li J#, Tong J, Cao B, Taylor P, Tang X, Wu D, Moran M, Zeng Y*, Mao X*., 2017
抗菌和抗病毒的南昌霉素通过靶向Otub1和c-Maf显示抗骨髓瘤活性。, Yujia Xu#, Tong Sun#, Kun Zeng, Min Xu, Jinhao Chen, Xiaofeng Xu, Zubin Zhang, Biyin Cao, Xiaowen Tang, Depei Wu, Yan Kong, Yuanying Zeng*, Xinliang Mao*., 2020
诱导锌指蛋白RNF6自泛素化治疗骨髓瘤和慢性髓性白血病。, Zhuang H, Ren Y, Mao C, Zhong Y, Zhang Z, Cao B, Zhang Y, Huang J, Xu G, Huang Z, Xu Y*, Mao X*., 2022
草药acevaltrate通过抑制Otub1/c-Maf轴诱导骨髓瘤细胞凋亡。, Tong Sun#, Yujia Xu#, Zhuan Xu#, Biyin Cao, Zubin Zhang, Qi Wang*, Yan Kong*, Xinliang Mao*., 2021
甲苯咪唑通过抑制USP5/c-Maf轴引发强效抗骨髓瘤活性。, Xue-Han Chen#, Yujia Xu#, Xiao-Ge Wang#, Peng Lin, Bi-Yin Cao, Yuan-Ying Zeng, Qi Wang, Zu-Bin Zhang*, Xin-Liang Mao*, Tie Zhang*., 2019
新型内过氧化物和4-苯胺喹唑啉结合物通过抑制IGF1-R/AKT/mTOR信号通路诱导骨髓瘤细胞凋亡。, Xu Y#, Zeng K#, Wang X, Zhang J, Cao B, Zhang Z, Qiao C, Xu X, Wang Q, Zeng Y, Mao X., 2020
一种新型STAT3抑制剂负调节血小板活化和聚集。, Zhuan Xu#, Yu-Jia Xu#, Ya-Nan Hao#, Li-Jie Ren, Zu-Bin Zhang, Xin Xu, Bi-Yin Cao, Ke-Sheng Dai, Li Zhu, Qi Fang*, Yan Kong*, Xin-Liang Mao*., 2017

蛋白质修饰铁死亡抗肿瘤小分子药物发现癌症研究生物化学分子生物学细胞死亡治疗学

徐国恒 - 北京大学

邵根泽 - 北京大学

童坦君 - 北京大学

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