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Ming Liu
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: English, Chinese
Tumor Plasticity
Heterogeneity
Drug Resistance
Immune Evasion
Molecular Mechanisms
Tumor Progression
Molecular Markers
Anti-Tumor Drugs
Therapeutic Strategies
Clinical Translation
Areas of Focus
- Exploring molecular mechanisms of tumor plasticity and heterogeneity leading to drug resistance and immune evasion
- Screening molecular markers and potential anti-tumor drug targets for monitoring malignant tumor progression
- Developing innovative drugs and therapeutic strategies targeting tumor plasticity
Work Experience
- 2014-2016 - The University of Hong Kong - Postdoctoral Researcher
- 2016-present - Guangzhou Medical University - Professor, Doctoral Supervisor
Academic Background & Achievements
- 2013 - PhD: The University of Hong Kong
- Outstanding Graduate: The University of Hong Kong
Publications
- Targeting tumor lineage plasticity in hepatocellular carcinoma using an anti-CLDN6 antibody-drug conjugate., Kong FE, Li GM, Tang YQ, Xi SY, Loong JHC, Li MM, Li HL, Cheng W, Zhu WJ, Mo JQ, Gong YF, Tang H, Zhao Y, Zhang Y, Ma S, Guan XY, Ma NF, Xie MB, Liu M., 2021
- PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma., Yang XD, Kong FE, Qi L, Lin JX, Yan Q, Loong JHC, Xi SY, Zhao Y, Zhang Y, Yuan YF, Ma NF, Ma S, Guan XY, Liu M., 2021
- A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets., Liu M, Yan Q, Sun Y, Nam Y, Hu L, Loong JHC, Ouyang Q, Zhang Y, Li HL, Kong FE, Li L, Li Y, Li MM, Cheng W, Jiang LX, Fang S, Yang XD, Mo JQ, Gong YF, Tang YQ, Li Y, Yuan YF, Ma NF, Lin G, Ma S, Wang JG, Guan XY., 2020
- Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway., Fang S, Liu M, Li L, Zhang FF, Li Y, Yan Q, Cui YZ, Zhu YH, Yuan YF, Guan XY., 2019
- CHD1L Promotes Lineage Reversion of Hepatocellular Carcinoma through Opening Chromatin for Key Developmental Transcription Factors., Liu M, Chen L, Ma NF, Chow RK, Li Y, Song Y, Chan TH, Fang S, Yang X, Xi S, Jiang L, Li Y, Zeng TT, Li Y, Yuan YF, Guan XY., 2016
- The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update., Liu M, Jiang L, Guan XY., 2014
- Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma., Liu M, Li Y, Chen L, Chan TH, Song Y, Fu L, Zeng TT, Dai YD, Zhu YH, Li Y, Chen J, Yuan YF, Guan XY., 2014
- Serum and glucocorticoid kinase 3 at 8q13.1 promote cell proliferation and survival in hepatocellular carcinoma., Liu M, Chen LL, Chan TH, Wang J, Li Y, Li Y, Zeng TT, Yuan YF, Guan XY., 2012
Awards
- 2018: Guangdong Province Higher Education 'Young Pearl River Scholar'
- 2017: Guangdong Province 'Pearl River Talent Plan' Young Top Talent
- 2015: Ministry of Education of the People's Republic of China Natural Science Second Prize (Fifth Contributor)
- 2014: Hong Kong Young Scientist Award
- 2014: The University of Hong Kong 'Dr KP Stephen Chang' Gold Medal
- 2013: The University of Hong Kong 'Yu To Sang and Yu Shing Keung' Cancer Research Memorial Fund Award
- 2013: The University of Hong Kong 'Mary Sun' Medical Research Award
- 2013: The University of Hong Kong 'YS and Christabel Lung' Medical Research Award
