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Xuejiang Guo
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: Chinese, English
Reproductive Health
Spermatogenesis
Infertility
Molecular Biology
Genetics
Proteomics
Male Reproductive System
Fertility
Sperm Function
Biomedical Research
Areas of Focus
- Reproductive Medicine
- Molecular Mechanisms of Spermatogenesis
- Male Infertility
Work Experience
- 2009-2011 - Nanjing Medical University - Lecturer
- 2011-2015 - Nanjing Medical University - Associate Professor
- 2014-2015 - Pacific Northwest National Laboratory (PNNL) - Visiting Scholar
- 2014-present - Nanjing Medical University - Distinguished Professor
- 2015-present - Nanjing Medical University - Professor, Doctoral Supervisor
- 2011-present - National Key Laboratory of Reproductive Medicine - PI
- 2018-present - National Key Laboratory of Reproductive Medicine - Deputy Director
Academic Background & Achievements
- 1999-2006 Bachelor and Master: Nanjing Medical University
- 2006-2009 Doctorate: Nanjing Medical University
- National Excellent Young Scientist Fund recipient (2012)
- Chief Scientist of National Key R&D Program Youth Project (2016)
Publications
- In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids., Yuan Y, Li L, Cheng Q, Diao F, Zeng Q, Yang X, Wu Y, Zhang H, Huang M, Chen J, Zhou Q, Zhu Y, Hua R, Tian J, Wang X, Zhou Z, Hao J, Yu J, Hua D, Liu J, Guo X*, Zhou Q*, Sha J*., 2020
- Phosphoproteomic Analysis of Neonatal Regenerative Myocardium Revealed Important Roles of CHK1 via Activating mTORC1/P70S6K Pathway., Fan Y#, Cheng Y#, Li Y, Chen B, Wang Z, Wei T, Zhang H, Guo Y, Wang Q, Wei Y, Chen F, Sha J, Guo X*, Wang L*., 2020
- RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila., Wang Y, Xu R, Cheng Y, Cao H, Wang Z, Zhu T, Jiang J, Zhang H, Wang C, Qi L, Liu M, Guo X*, Huang J*, Sha J*., 2019
- Proteomic Analysis of Dpy19l2-Deficient Human Globozoospermia Reveals Multiple Molecular Defects., Guo Y#, Jiang J#, Zhang H#, Wen Y, Zhang H, Cui Y, Tian J, Jiang M, Liu X, Wang G, Li Y, Hu Z, Zhou Z, Sha J, Chen D*, Yang X*, Guo X*., 2019
- The Protein Phosphorylation Landscape of Mouse Spermatids during Spermiogenesis., Li Y#, Cheng Y#, Zhu T#, Zhang H, Li W, Guo Y, Qi Y, Chen X, Zhang J, Sha J, Zhou Z, Zhu H*, Guo X*., 2019
- Mitofusin1 in oocyte is essential for female fertility., Hou X#, Zhu S#, Zhang H#, Li C#, Qiu D, Ge J, Guo X*, Wang Q*., 2019
- Proteomics analysis of asthenozoospermia and identification of glucose-6-phosphate isomerase as an important enzyme for sperm motility., Guo Y#, Jiang W#, Yu W#, Niu X, Liu F, Zhou T, Zhang H, Li Y, Zhu H, Zhou Z, Sha J, Guo X*, Chen D*., 2019
- Generation of isogenic single and multiplex gene knockout mice by base editing-induced STOP., Guang Yang#, Tianyu Zhu#, Zongyang Lu, Guanglei Li, Hao Zhang, Songjie Feng, Yajing Liu, Jianan Li,Yu Zhang, Jia Chen, Xuejiang Guo*, Xingxu Huang*., 2018
- Distinct temporal requirements for autophagy and the proteasome in yeast meiosis., Wen FP#, Guo YS#, Hu Y, Liu WX, Wang Q, Wang YT, Yu HY, Tang CM, Yang J, Zhou T, Xie ZP, Sha JH, Guo X*, Li W*., 2016
- The need to revisit published data: A concept and framework for complementary proteomics., Zhou T, Sha J, Guo X*., 2016
Awards
- 2019: Jiangsu Provincial Science and Technology Award First Prize
- 2019: Ministry of Education Natural Science Second Prize
- 2017: National Maternal and Child Health Science and Technology Award First Prize
- 2015: National Science and Technology Progress Award Second Prize
- 2014: Ministry of Education Natural Science Second Prize
- 2014: Jiangsu Provincial Science and Technology Award First Prize
- 2011: Excellent Scientific Achievement Award First Prize
- 2011: Ministry of Education Natural Science Second Prize
