1986-09 ~ 1991-07 Bachelor of Clinical Medicine: Nanjing Medical College
1993-09 ~ 1998-07 Doctorate in Pharmacology: Nanjing Medical University
National 'Ten Thousand Talents Program' member
Recipient of the State Council Special Allowance
1991-08 ~ 1995-07 - Nanjing Medical University - Assistant
1995-08 ~ 2000-11 - Nanjing Medical University - Lecturer, Deputy Director
2000-12 ~ 2002-01 - French National Institute of Health and Medical Research - Postdoctoral Researcher
2002-02 ~ 2004-04 - King's College London - Assistant Researcher
2004-04 ~ Present - Nanjing Medical University - Professor, Doctoral Supervisor
2015-12 ~ 2018-02 - Nanjing Medical University - Dean of School of Pharmacy
2017-06 ~ Present - Nanjing Medical University - Vice President
2021: Jiangsu Science and Technology Award First Prize
2020: Second Prize of the 8th 'China Overseas Chinese Contribution Award'
2019: Second Prize of the Chinese Medical Science and Technology Award
2018: State Council Special Allowance Expert
2017: National 'Ten Thousand Talents Program' member
2016: First Prize of the Ministry of Education Natural Science Award
Research
Molecular mechanisms and drug prevention of cardiovascular diseases
Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis., Zhao S, Tang X, Miao Z, Chen Y, Cao J, Song T, You D, Zhong Y, Lin Z, Wang D, Shi Z, Tang X, Wang D, Chen S, Wang L, Gu A, Chen F, Xie L, Huang Z, Wang H, Ji Y., 2022
S-nitrosylation of c-Jun N-terminal kinase mediates pressure overload-induced cardiac dysfunction and fibrosis., Zhou M, Chen J, Chao M, Zhang C, Shi Z, Zhou X, Xie L, Sun S, Huang Z, Luo S, Ji Y., 2022
S-nitrosylation of Hsp90 promotes cardiac hypertrophy in mice through GSK3β signaling., Zhao S, Song T, Wang Z, Gao J, Cao J, Hu L, Huang Z, Xie L, Ji Y., 2021
S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis., Chao M, Luo S, Zhang C, Zhou X, Zhou M, Wang J, Kong C, Chen J, Lin Z, Tang X, Sun S, Tang X, Chen H, Wang H, Wang D, Sun J, Han Y, Xie L, Ji Y., 2021
HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression., Zhang Y, Da Q, Cao S, Yan K, Shi Z, Miao Q, Li C, Hu L, Sun S, Wu W, Wu L, Chen F, Wang L, Gao Y, Huang Z, Shao Y, Chen H, Wei Y, Chen F, Han Y, Xie L, Ji Y., 2021
Inhibition of HSP90 S-nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway., Zhang X, Zhang Y, Miao Q, Shi Z, Hu L, Liu S, Gao J, Zhao S, Chen H, Huang Z, Han Y, Ji Y, Xie L., 2021
Implications of cardiac markers in risk-stratification and management for COVID-19 patients., Li P, Wu W, Zhang T, Wang Z, Li J, Zhu M, Liang Y, You W, Li K, Ding R, Huang B, Wu L, Duan W, Han Y, Li X, Tang X, Wang X, Shen H, Wang Q, Yan H, Xia X, Ji Y, Chen H., 2021
Hydrogen Sulfide Alleviates Liver Injury Through the S-Sulfhydrated-Kelch-Like ECH-Associated Protein 1/Nuclear Erythroid 2-Related Factor 2/Low-Density Lipoprotein Receptor-Related Protein 1 Pathway., Zhao S, Song T, Gu Y, Zhang Y, Cao S, Miao Q, Zhang X, Chen H, Gao Y, Zhang L, Han Y, Wang H, Pu J, Xie L, Ji Y., 2021
SNO-MLP (S-Nitrosylation of Muscle LIM Protein) Facilitates Myocardial Hypertrophy Through TLR3 (Toll-Like Receptor 3)-Mediated RIP3 (Receptor-Interacting Protein Kinase 3) and NLRP3 (NOD-Like Receptor Pyrin Domain Containing 3) Inflammasome Activation., Tang X, Pan L, Zhao S, Dai F, Chao M, Jiang H, Li X, Lin Z, Huang Z, Meng G, Wang C, Chen C, Liu J, Wang X, Ferro A, Wang H, Chen H, Gao Y, Lu Q, Xie L, Han Y, Ji Y., 2020
The S-nitrosylation of Plastin-3 Exacerbates Thoracic Aortic Dissection Formation via Endothelial Barrier Dysfunction., Pan L, Lin Z, Tang X, Tian J, Zheng Q, Jing J, Xie L, Chen H, Lu Q, Wang H, Li Q, Han Y, Ji Y., 2020
BRD4 Contributes to LPS-induced Macrophage Senescence and Promotes Progression of Atherosclerosis-Associated Lipid Uptake., Wang H, Fu H, Zhu R, Wu X, Ji X, Li X, Jiang H, Lin Z, Tang X, Sun S, Chen J, Wang X, Li Q, Ji Y, Chen H., 2020
Kupffer Cells Promote T-cell Hepatitis by Producing CXCL10 and Limiting Liver Sinusoidal Endothelial Cell Permeability., Dai S, Liu F, Qin Z, Zhang J, Chen J, Ding W, Feng D, Ji Y, Qin X., 2020
Combined Primary PCI with Multiple Thrombus Burden Reduction Therapy Improved Cardiac Function in Patients with Acute Anterior Myocardial Infarction., Wang K, Zhang J, Zhang N, Shen Y, Wang L, Gu R, Xu B, Ji Y., 2019
eNOS S-nitrosylation mediated OxLDL-induced endothelial dysfunction via increasing the interaction of eNOS with β-catenin., Wang W, Wang D, Kong C, Li S, Xie L, Lin Z, Zheng Y, Zhou J, Han Y, Ji Y., 2019
Autophagy promotes fibrosis and apoptosis in the peritoneum during long-term peritoneal dialysis., Wu J, Xing C, Zhang L, Mao H, Chen X, Liang M, Wang F, Ren H, Cui H, Jiang A, Wang Z, Zou M, Ji Y., 2018
Spotlight on small molecules in cardiovascular diseases., Wang X, Huang Y, Ji Y., 2018
Identification of homocysteine-suppressive mitochondrial ETC complex genes and tissue expression profile - Novel hypothesis establishment., Cueto R, Zhang L, Shan H, Huang X, Li X, Li Y, Lopez J, Yang W, Lavallee M, Yu C, Ji Y, Yang X, Wang H., 2018
Hydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasome activation via S-sulfhydrating c-Jun at Cys269 in macrophages., Lin Z, Altaf N, Li C, Chen M, Pan L, Wang D, Xie L, Zheng Y, Fu H, Han Y, Ji Y., 2018
Protein S-sulfhydration by hydrogen sulfide in cardiovascular system., Meng G, Zhao S, Xie L, Han Y, Ji Y., 2018
Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3 dependent manner., Meng G, Liu J, Liu S, Song Q, Liu L, Xie L, Han Y, Ji Y., 2018
Hydrogen sulfide as a potential target in preventing spermatogenic failure and testicular dysfunction., Wang J, Wang W, Li S, Han Y, Zhang P, Meng G, Xiao Y, Xie L, Wang X, Sha J, Chen Q, Moore PK, Wang R, Xiang W, Ji Y., 2018
Aliskiren protects against myocardial ischaemia-reperfusion injury via an endothelial nitric oxide synthase dependent manner., Chen Y, Meng G, Bai W, Ma Y, Xie L, Altaf N, Qian Y, Han Y, Ji Y., 2017
Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling., Liu W, Ruiz-Velasco A, Wang S, Khan S, Zi M, Jungmann A, Dolores Camacho-Muñoz M, Guo J, Du G, Xie L, Oceandy D, Nicolaou A, Galli G, Müller OJ, Cartwright EJ, Ji Y, Wang X., 2017
SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells., Xie L, Feng H, Li S, Meng G, Liu S, Tang X, Ma Y, Han Y, Xiao Y, Gu Y, Shao Y, Park CM, Xian M, Huang Y, Ferro A, Wang R, Moore PK, Wang H, Ji Y., 2016
Aliskiren improves endothelium-dependent relaxation of thoracic aorta by activating PI3K/Akt/eNOS signal pathway in SHR., Gu Y, Tang X, Xie L, Meng G, Ji Y., 2016
Soy Isoflavone Protects Myocardial Ischemia/Reperfusion Injury through Increasing Endothelial Nitric Oxide Synthase and Decreasing Oxidative Stress in Ovariectomized Rats., Tang Y, Li S, Zhang P, Zhu J, Meng G, Xie L, Yu Y, Ji Y, Han Y., 2016
Loss of Caspase-Activated DNase Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice., Chao M, Guo J, Cheng W, Zhu X, She Z, Huang Z, Ji Y, Li H., 2016
Hydrogen Sulfide Regulates Krüppel-Like Factor 5 Transcription Activity via Specificity Protein 1 S-Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy., Meng G, Xiao Y, Ma Y, Tang X, Xie L, Liu J, Gu Y, Yu Y, Park CM, Xian M, Wang X, Ferro A, Wang R, Moore PK, Zhang Z, Wang H, Han Y, Ji Y., 2016
Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation., Xie L, Gu Y, Wen M, Zhao S, Wang W, Ma Y, Meng G, Han Y, Wang Y, Liu G, Moore PK, Wang X, Wang H, Zhang Z, Yu Y, Ferro A, Huang Z, Ji Y., 2016
Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial Cells., Xi H, Zhang Y, Xu Y, Yang WY, Jiang X, Sha X, Cheng X, Wang J, Qin X, Yu J, Ji Y, Yang X, Wang H., 2016
Chronic Kidney Disease Induces Inflammatory CD40+ Monocyte Differentiation via Homocysteine Elevation and DNA Hypomethylation., Yang J, Fang P, Yu D, Zhang L, Zhang D, Jiang X, Yang WY, Bottiglieri T, Kunapuli SP, Yu J, Choi ET, Ji Y, Yang X, Wang H., 2016
