Professor | Shuo Yang | Asia Growth Partners

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Name	Shuo Yang
Contact Information	shuoyang@njmu.edu.cn
Language ability	Chinese, English
Province	Jiangsu

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Name

Shuo Yang

Contact Information

shuoyang@njmu.edu.cn

Language ability

Chinese, English

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1997.9-2001.6 Bachelor: Suzhou University 2001.9-2008.1 Doctorate: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences Selected for National High-Level Young Talent Program Selected for Jiangsu Distinguished Professor Program Selected for Jiangsu 333 High-Level Talent Training Project
Work Experience	2008.11-2015.9 Postdoctoral Researcher: National University of Ireland, Maynooth, Institute of Immunology 2015.10-present Professor: Nanjing Medical University, Department of Immunology
Awards	2005: Chinese Academy of Sciences Outstanding Graduate Award 2007: First Prize of the Chinese Academy of Sciences 'Di Ao Scholarship'

University/Lab Affiliation and Title

Nanjing Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1997.9-2001.6 Bachelor: Suzhou University
2001.9-2008.1 Doctorate: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Selected for National High-Level Young Talent Program
Selected for Jiangsu Distinguished Professor Program
Selected for Jiangsu 333 High-Level Talent Training Project

Work Experience

2008.11-2015.9 Postdoctoral Researcher: National University of Ireland, Maynooth, Institute of Immunology
2015.10-present Professor: Nanjing Medical University, Department of Immunology

Awards

2005: Chinese Academy of Sciences Outstanding Graduate Award
2007: First Prize of the Chinese Academy of Sciences 'Di Ao Scholarship'

Areas of Focus	Molecular regulation and intervention of immune-inflammatory diseases
Publications	ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis., Yang, Y., Wang, Y., Wang, Z., Yan, H., Gong, Y., Hu, Y., Jiang, Y., Wen, S., Xu, F., Wang, B., Humphries, F., Chen, Y., Wang, X., Yang, S., 2024 Gasdermin D in macrophages drives orchitis by regulating inflammation and antigen presentation processes., Ma, C., Huang, J., Jiang, Y., Liu, L., Wang, N., Huang, S., Li, H., Zhang, X., Wen, S., Wang, B., Yang, S., 2024 ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein., Jiang, Y., Ma, C., Hu, Y., Yang, Y., Ma, C., Wu, C., Liu, L., Wen, S., Moynagh, P.N., Wang, B., Yang, S., 2023 GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson's disease., Wang, B., Ma, Y., Li, S., Yao, H., Gu, M., Liu, Y., Xue, Y., Ding, J., Ma, C., Yang, S., Hu, G., 2023 The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11., Hu, Y., Jiang, Y., Li, S., Ma, X., Chen, M., Yang, R., Wen, S., Moynagh, P.N., Wang, B., Hu, G., Yang, S., 2022 Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade., Jiang, Y., Yang, Y., Hu, Y., Yang, R., Huang, J., Liu, Y., Wu, Y., Li, S., Ma, C., Humphries, F., Wang, B., Wang, X., Hu, Z., Yang, S., 2022 Pyroptosis, and its Role in Central Nervous System Disease., Hu, Y., Wang, B., Li, S., Yang, S., 2022 DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization., Liu, L., Wu, Y., Wang, B., Jiang, Y., Lin, L., Li, X., Yang, S., 2021 AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis., Ma, C., Li, S., Hu, Y., Ma Y., Wu, Y., Wu, C., Liu, X., Wang, B., Hu, G., Zhou, J., Yang, S., 2021 Succination inactivates gasdermin D and blocks pyroptosis., Humphries, F., Shmuel-Galia, L., Ketelut-Carneiro, N., Li, S., Wang, B., Nemmara, V.V., Wilson, R., Jiang, Z., Khalighinejad, F., Muneeruddin, K., Shaffer, S.A., Dutta, R., Ionete, C., Pesiridis, S., Yang, S., Thompson, P.R., Fitzgerald, K.A., 2020 Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation., Ma, C., Yang, D., Wang, B., Wu, C., Wu, Y., Li, S., Liu, X., Lassen, K., Dai, L., Yang, S., 2020 Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation., Wu, Y., Hu, Y., Wang, B., Li, S., Ma, C., Liu, X., Moynagh, P. N., Zhou, J., Yang, S., 2020 Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis., Li, S., Wu, Y., Yang, D., Wu, C., Ma, C., Liu, X., Moynagh, P. N., Wang, B., Hu, G., Yang, S., 2019 The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance., Yang, S., Wang, B., Humphries, F., Hogan, A.E., O’Shea, D., Moynagh, P.N., 2014 Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis., Yang, S., Wang, B., Humphries, F., Jackson, R., Healy, M.E., Bergin, R., Aviello, G., Hall, B., McNamara, D., Darby, T., Quinlan, A., Shanahan, F., Melgar, S., Fallon, P.G., Moynagh, P.N., 2013

Areas of Focus

Molecular regulation and intervention of immune-inflammatory diseases

Publications

ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis., Yang, Y., Wang, Y., Wang, Z., Yan, H., Gong, Y., Hu, Y., Jiang, Y., Wen, S., Xu, F., Wang, B., Humphries, F., Chen, Y., Wang, X., Yang, S., 2024
Gasdermin D in macrophages drives orchitis by regulating inflammation and antigen presentation processes., Ma, C., Huang, J., Jiang, Y., Liu, L., Wang, N., Huang, S., Li, H., Zhang, X., Wen, S., Wang, B., Yang, S., 2024
ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein., Jiang, Y., Ma, C., Hu, Y., Yang, Y., Ma, C., Wu, C., Liu, L., Wen, S., Moynagh, P.N., Wang, B., Yang, S., 2023
GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson's disease., Wang, B., Ma, Y., Li, S., Yao, H., Gu, M., Liu, Y., Xue, Y., Ding, J., Ma, C., Yang, S., Hu, G., 2023
The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11., Hu, Y., Jiang, Y., Li, S., Ma, X., Chen, M., Yang, R., Wen, S., Moynagh, P.N., Wang, B., Hu, G., Yang, S., 2022
Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade., Jiang, Y., Yang, Y., Hu, Y., Yang, R., Huang, J., Liu, Y., Wu, Y., Li, S., Ma, C., Humphries, F., Wang, B., Wang, X., Hu, Z., Yang, S., 2022
Pyroptosis, and its Role in Central Nervous System Disease., Hu, Y., Wang, B., Li, S., Yang, S., 2022
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization., Liu, L., Wu, Y., Wang, B., Jiang, Y., Lin, L., Li, X., Yang, S., 2021
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis., Ma, C., Li, S., Hu, Y., Ma Y., Wu, Y., Wu, C., Liu, X., Wang, B., Hu, G., Zhou, J., Yang, S., 2021
Succination inactivates gasdermin D and blocks pyroptosis., Humphries, F., Shmuel-Galia, L., Ketelut-Carneiro, N., Li, S., Wang, B., Nemmara, V.V., Wilson, R., Jiang, Z., Khalighinejad, F., Muneeruddin, K., Shaffer, S.A., Dutta, R., Ionete, C., Pesiridis, S., Yang, S., Thompson, P.R., Fitzgerald, K.A., 2020
Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation., Ma, C., Yang, D., Wang, B., Wu, C., Wu, Y., Li, S., Liu, X., Lassen, K., Dai, L., Yang, S., 2020
Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation., Wu, Y., Hu, Y., Wang, B., Li, S., Ma, C., Liu, X., Moynagh, P. N., Zhou, J., Yang, S., 2020
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis., Li, S., Wu, Y., Yang, D., Wu, C., Ma, C., Liu, X., Moynagh, P. N., Wang, B., Hu, G., Yang, S., 2019
The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance., Yang, S., Wang, B., Humphries, F., Hogan, A.E., O’Shea, D., Moynagh, P.N., 2014
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis., Yang, S., Wang, B., Humphries, F., Jackson, R., Healy, M.E., Bergin, R., Aviello, G., Hall, B., McNamara, D., Darby, T., Quinlan, A., Shanahan, F., Melgar, S., Fallon, P.G., Moynagh, P.N., 2013

Immune-Inflammatory Diseases Molecular Regulation Intervention Neuroinflammation Multiple Sclerosis Gasdermin D Immune Pathology Drug Development Cell Signaling Therapeutic Targets

Ai-Ling Li - Fudan University

Jie Yan - Guangzhou Medical University

Chongxiu Sun - Nanjing Medical University

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