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Yunzi Chen
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: Chinese, English
Inflammation
Disease
Pathogenesis
Nutrients
Molecular Mechanisms
Vitamin D
Receptor
Mucosal Immunity
Immune Response
Inflammatory Pathways
Areas of Focus
- Pathogenesis of inflammatory diseases, focusing on the role and molecular mechanisms of nutrients
- Role and mechanisms of vitamin D and its receptor in mucosal immunity and inflammation
Work Experience
- 2006-2012 - University of Chicago - Postdoctoral Researcher
- 2012-2013 - China Medical University - Lecturer
- 2014-present - Nanjing Medical University - Lecturer
Academic Background & Achievements
- 2000-2005 PhD in Biochemistry and Molecular Biology: Nanjing University
- Published research in renowned international journals such as J. Clin. Invest., J. Immunol., J. Bio. Chem., Inflamm. Bowel Dis.
Publications
- 1,25-Dihydroxyvitamin D Inhibits LPS-Induced High-Mobility Group Box 1 (HMGB1) Secretion via Targeting the NF-E2-Related Factor 2-Hemeoxygenase-1-HMGB1 Pathway in Macrophages, Rao Z, Zhang N, Xu N, Pan Y, Xiao M, Wu J, Zhou H, Yang S, Chen Y*, 2017
- 1,25-Dihydroxyvitamin D Protects Intestinal Epithelial Barrier by Regulating the Myosin Light Chain Kinase Signaling Pathway, Du J, Chen Y*, Shi Y, Liu T, Cao Y, Tang Y, Ge X, Nie H, Zheng C, Li YC, 2015
- MicroRNA-346 Mediates Tumor Necrosis Factor α-Induced Downregulation of Gut Epithelial Vitamin D Receptor in Inflammatory Bowel Diseases, Chen Y*, Du J, Zhang Z, Liu T, Shi Y, Ge X, Li YC, 2014
- Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis, Liu W*, Chen Y*, Golan M.A., Annunziata M.L., Du J, Dougherty U., Kong J, Musch M., Huang Y, Pekow J., Zheng C, Bissonnette M., Hanauer S.B., Li YC, 2013
- 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages, Chen Y, Liu W, Sun T, Huang Y, Wang Y, Deb D.K., Yoon D, Kong J, Thadhani R., Li YC, 2013
- Vitamin D receptor inhibits nuclear factor κB activation by interacting with IκB kinase β protein, Chen Y, Zhang J, Ge X, Du J, Deb D.K., Li YC, 2013
