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Jian Yang
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: Chinese, English
Transcription Factor Dec1
Drug Metabolism
Fat Metabolism
Bone Metabolism
Metabolic Diseases
Clinical Pharmacology
Pharmacology
Teaching
Research
Nih Projects
Areas of Focus
- Clinical Pharmacology
Work Experience
- 1990-2000 - Jiangsu Workers' Medical University - Lecturer, Associate Professor
- 2001-present - Nanjing Medical University, School of Basic Medical Sciences - Associate Professor, Professor
- 2004-2008 - University of Rhode Island, College of Pharmacy - Visiting Scholar, Postdoctoral Researcher
Academic Background & Achievements
- 1979-1984 Bachelor's Degree: Nanjing Medical University
- 1987-1990 Master's Degree in Pharmacology: Nanjing University of Chinese Medicine
- 2002-2008 Doctorate in Pharmacology: Nanjing Medical University
- Published over 30 SCI papers as first or corresponding author
Publications
- The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling, Zhu Z, Wu Y, Zhang Z, Ge D, Lu M, Liu W, Shan E, Hu G, Hiroaki H, Yang J*, 2019
- 17β-estradiol suppresses carboxylesterases by activating c-Jun/AP-1 pathway in primary human and mouse hepatocytes, Wu L, Hafiz MZ, Guan Y, He S, Xiong J, Liu W, Yan B, Li X, Yang J*, 2018
- Neuroligin-3 protects retinal cells from H2O2-induced cell death via activation of Nrf2 signaling, Li XM, Huang D, Yu Q, Yang J*, Yao J*, 2018
- Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3β/β-catenin integrated signaling pathway, Hu J, Mao Z, He S, Zhan Y, Ning R, Liu W, Yan B, Yang J*, 2017
- Downregulation of DEC1 contributes to the neurotoxicity induced by MPP+ by suppressing PI3K/Akt/GSK3β pathway, Zhu Z, Wang YW, Ge DH, Lu M, Liu W, Xiong J, Hu G, Li XP, Yang J*, 2017
- Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXRα and Suppresses the Expression of PXR, CAR and Their Target Genes, Ning R, Zhan Y, He S, Hu J, Zhu Z, Hu G, Yan B, Yang J*, Liu W*, 2017
- Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells, Liu W, Ning R, Chen RN, Huang XF, Dai QS, Hu JH, Wang YW, Wu LL, Xiong J, Hu G, Guo QL, Yang J*, Wang H*, 2016
- Gambogic acid suppresses cytochrome P450 3A4 by downregulating pregnane X receptor and up-regulating DEC1 in human hepatoma HepG2 cells, Wei Liu, Rui Ning, Rui-Ni Chen, Jin-Hua Hu, Hai-Yan Gui, Yu-Wen Wang, Jie Liu, Gang Hu, Jian Yang* and Qing-Long Guo*, 2015
Awards
- Nanjing Medical University 'Three Educators' Model' (2016)
- Yangtze River Teaching Award Excellence Award (2014)
- Third Prize in National Undergraduate Basic Medical Innovation Forum and Experimental Design Competition (2013)
- Jiangsu Province 'Six Talent Peaks' (Category B) High-level Talent Training Object (2008)
- Military Science and Technology Progress Third Prize (2003)
