1980-1986: Bachelor's in Medicine, Tongji Medical University
1986-1989: Master's in Microbiology and Immunology, Tongji Medical University
1991-1994: PhD in Immunology, University of Würzburg, Germany
Director of Jiangsu Key Laboratory of Human Functional Genomics
Published over 70 papers in SCI journals
1994-1996: Postdoctoral Research in Metabolic Diseases, University of Münster, Germany
1997-2003: Research on Molecular Mechanisms of Islet β-cell Dysfunction and Apoptosis, City of Hope National Medical Center, USA
2003-present: Professor, Department of Biochemistry and Molecular Biology, Nanjing Medical University
2007: Jiangsu Province Science and Technology Progress Award, Second Prize
2016: Ministry of Education Natural Science Award, Second Prize
2016: Jiangsu Province Science and Technology Progress Award, Second Prize
2017: Nanjing City Science and Technology Progress Award, Third Prize
2017: Jiangsu Medical Science and Technology Award, Second Prize
Research
Mechanisms of Type 2 Diabetes Development
Specific Deletion of CASK in Pancreatic β Cells Affects Glucose Homeostasis and Improves Insulin Sensitivity in Obese Mice by Reducing Hyperinsulinemia, Liu X, Sun P, Yuan Q, Xie J, Xiao T, Zhang K, Chen X, Wang Y, Yuan L, Han X, 2021
Exploiting D2 receptor β-arrestin2-biased signalling to suppress tumour growth of pituitary adenomas, Tan Z, Lei Z, Yan Z, Ji X, Chang X, Cai Z, Lu L, Qi Y, Yin X, Han X, Lei T, 2021
Lentinan protects against pancreatic β-cell failure in chronic ethanol consumption-induced diabetic mice via enhancing β-cell antioxidant capacity, Wu T, Wang J, Zhang Y, Shao Y, Li X, Guo Y, Dong W, Wang L, Chen F, Han X, 2021
PPA1 Regulates Systemic Insulin Sensitivity by Maintaining Adipocyte Mitochondria Function as a Novel PPARγ Target Gene, Yin Y, Wu Y, Zhang X, Zhu Y, Sun Y, Yu J, Gong Y, Sun P, Lin H, Han X, 2021
M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3β/β-catenin pathway in mice, Qian B, Yang Y, Tang N, Wang J, Sun P, Yang N, Chen F, Wu T, Sun T, Li Y, Chang X, Zhu Y, Zhang Y, Han X, 2021
Three-dimensional cell-culture platform based on hydrogel with tunable microenvironmental properties to improve insulin-secreting function of MIN6 cells, Zhang M, Yan S, Xu XQ, Yu TT, Guo ZB, Ma M, Zhang T, Gu ZX, Feng YW, Du CY, Wan MQ, Hu K, Han X, Gu N, 2021
Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3, Sun Y, Zhou Y, Shi Y, Zhang Y, Liu K, Liang R, Sun P, Chang X, Tang W, Zhang Y, Li J, Wang S, Zhu Y, Han X, 2021
Inhibition of miR-153, an IL-1β-responsive miRNA, prevents beta cell failure and inflammation-associated diabetes, Sun Y, Zhou S, Shi Y, Zhou Y, Zhang Y, Liu K, Zhu Y, Han X, 2020
Inhibition of heparanase protects against pancreatic beta cell death in streptozotocin-induced diabetic mice via reducing intra-islet inflammatory cell infiltration, Song WY, Jiang XH, Ding Y, Wang Y, Zhou MX, Xia Y, Zhang CY, Yin CC, Qiu C, Li K, Sun P, Han X, 2020
Death versus dedifferentiation: The molecular bases of beta cell mass reduction in type 2 diabetes, Sun T, Han X, 2020
HRD1, an Important Player in Pancreatic β-Cell Failure and Therapeutic Target for Type 2 Diabetic Mice, Wu T, Zhang S, Xu J, Zhang Y, Sun T, Shao Y, Wang J, Tang W, Chen F, Han X, 2020
MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis, Zhu Y, Sun Y, Zhou Y, Zhang Y, Zhang T, Li Y, You W, Chang X, Yuan L, Han X, 2019
Ets-1 deficiency alleviates nonalcoholic steatohepatitis via weakening TGF-β1 signaling-mediated hepatocyte apoptosis, Liu D, Wang K, Li K, Xu R, Chang X, Zhu Y, Sun P, Han X, 2019
Ets1-Mediated Acetylation of FoxO1 Is Critical for Gluconeogenesis Regulation during Feed-Fast Cycles, Li K, Qiu C, Sun P, Liu DC, Wu TJ, Wang K, Zhou YC, Chang XA, Yin Y, Chen F, Zhu YX, Han X, 2019
Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic β-Cell Function and Survival, Huang Q, You W, Li Y, Sun Y, Zhou Y, Zhang Y, Liu D, Zhan S, Zhu Y, Han X, 2018
A Presenilin/Notch1 pathway regulated by miR-375, miR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis, Li Y, Zhang T, Zhou Y, Sun Y, Cao Y, Chang X, Zhu Y, Han X, 2016
Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155, Zhang Y, Mei H, Chang X, Chen F, Zhu Y, Han X, 2016
Inhibition of tumor suppressor p53 preserves glycation-serum induced pancreatic beta-cell demise, Li Y, Zhang T, Huang Q, Sun Y, Chang X, Zhang H, Zhu Y, Han X, 2016
Lentinan protects pancreatic β cells from STZ-induced damage, Zhang Y, Mei H, Shan W, Shi L, Chang X, Zhu Y, Chen F, Han X, 2016
LXR activation causes G1/S arrest through inhibiting SKP2 expression in MIN6 pancreatic beta cells, Li Y, Jing C, Tang X, Chen Y, Han X, Zhu Y, 2016
Type 2 diabetes mitigation in the diabetic Goto-Kakizaki rat by elevated bile acids following a common-bile-duct surgery, Gao F, Zhang X, Zhou L, Zhou S, Zheng Y, Yu J, Fan W, Zhu Y, Han X, 2016
Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models, Chen F, Sha M, Wang Y, Wu T, Shan W, Liu J, Zhou W, Zhu Y, Sun Y, Shi Y, Bleich D, Han X, 2016
