1999/9–2004/6 Bachelor in Clinical Medicine: Nanjing Medical University
2006/9–2009/12 Master in Pathology and Pathophysiology: Nanjing Medical University
2010/9–2013/6 PhD in Cell Biology: Nanjing Normal University
Published over 60 SCI-indexed papers
Granted 6 national invention patents
2004/7-2015/8 - Nanjing Medical University - Research Assistant at Jiangsu Key Laboratory of Human Functional Genomics
2015/9-2017/10 - Nanjing Medical University - Lecturer/Postdoctoral Researcher in Basic Medicine
2017/11-2023/6 - Nanjing Medical University - Associate Researcher in Biochemistry and Molecular Biology
2023/7-present - Nanjing Medical University - Professor in Biochemistry and Molecular Biology
2016: Ministry of Education Natural Science Award, Second Prize, for research on molecules related to pancreatic β-cell function
2016: Jiangsu Province Science and Technology Progress Award, Second Prize, for research on molecular mechanisms of endoplasmic reticulum stress leading to type 2 diabetes β-cell dysfunction
2016: Jiangsu Province Education Science Achievement Award, Second Prize, for research on molecular mechanisms of endoplasmic reticulum stress leading to type 2 diabetes β-cell dysfunction
2017: Nanjing City Science and Technology Progress Award, Third Prize, for research on molecular mechanisms of type 2 diabetes
2007: Jiangsu Province Science and Technology Progress Award, Second Prize, for research on mechanisms of inflammation-induced diabetes and pancreatic β-cell dysfunction
Research
Epigenetic mechanisms of β-cell decompensation in diabetes
The miR-203/ZBTB20/MAFA axis orchestrates pancreatic β-cell maturation and identity during weaning and diabetes., Li Y, Yang Y, Sun Y, He L, Zhao L, Sun H, Chang X, Liang R, Wang S, Han X*, and Zhu Y*., 2024
Inhibiting arachidonic acid generation mitigates aging-induced hyperinsulinemia and insulin resistance in mice., Xiao X, Yang L, Xiao L, Li Y, Chang X, Han X, Tang W*, Zhu Y*., 2024
Beta-cell MiRNA-503-5p Induced by Hypomethylation and Inflammation Promotes Insulin Resistance and β-Cell Decompensation., Zhou, Y., Liu, K., Tang, W., Zhang, Y., Sun, Y., Wu, Y., Shi, Y., Yao, Z., Li, Y., Bai, R., Liang, R., Sun, P., Chang, X., Wang, S., Zhu Y*, and Han X*., 2024
Islet-resident macrophage-derived miR-155 promotes β cell decompensation via targeting PDX1., Zhang Y, Cong R, Lv T, Liu K, Chang X, Li Y, Han X, Zhu Y*., 2024
Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreatic β-cell Dysfunction., Wang K, Wu S, Yao Z, Zhu Y*, Han X*., 2024
Polypeptide N-Acetylgalactosaminyl transferase 14 is a novel mediator in pancreatic β-cell function and growth., Shu T, Zhang Y, Sun T, Zhu Y*., 2024
BRSK2 in Pancreatic β Cells Promotes Hyperinsulinemia-Coupled Insulin Resistance and Its Genetic Variants are Associated with Human Type 2 Diabetes., Xu R, Wang K, Yao Z, Zhang Y, Jin L, Pang J, Zhou Y, Wang K, Liu D, Zhang YQ, Sun P, Wang F, Chang X, Liu T, Wang S, Zhang YL, Lin S, Hu C*, Zhu Y*, and Han X*., 2023
Rab31, a receptor of advanced glycation end products (RAGE) interacting protein, inhibits AGE induced pancreatic β-cell apoptosis through the pAKT/BCL2 pathway., Bai R, Zhang T, Gao Y, Shu T, Zhou Y, Wang F, Chang X, Tang W*, Zhu Y*, Han X., 2022
miR-25 and miR-92b regulate insulin biosynthesis and pancreatic β-cell apoptosis., Shen Z, Yu Y, Yang Y, Xiao X, Sun T, Chang X, Tang W*, Zhu Y*, Han X., 2022
Protocol for in vivo and ex vivo assessments of glucose-stimulated insulin secretion in mouse islet β cells., Zhu Y*, Zhou YC, Zhang Y, Sun P, Chang XA, Han X*., 2021
Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3., Sun Y, Zhou Y, Shi Y, Zhang Y, Liu K, Liang R, Sun P, Chang X, Tang W, Zhang Y, Li J, Wang S, Zhu Y*, Han X*., 2021
Inhibition of miR-153, an IL-1β-responsive miRNA, prevents beta cell failure and inflammation-associated diabetes., Sun Y, Zhou S, Shi Y, Zhou Y, Zhang Y, Liu K, Zhu Y*, Han X*., 2020
MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis., Zhu Y*, Sun Y, Zhou Y, Zhang Y, Zhang T, Li Y, You W, Chang X, Yuan L, Han X., 2019
Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic β-Cell Function and Survival., Huang Q, You W, Li Y, Sun Y, Zhou Y, Zhang Y, Liu D, Zhan S, Zhu Y*, Han X*., 2018
Mechanistic study of CBT-Cys click reaction and its application for identifying bioactive N-terminal cysteine peptides in amniotic fluid., Zheng Z*, Chen P*, Li G*, Zhu Y*, Shi Z, Luo Y, Zhao C, Fu Z, Cui X, Ji C, Wang F, Huang G, Liang G., 2017
Boronic Acid-Modified Magnetic Fe(3)O(4)@mTiO(2) Microspheres for Highly Sensitive and Selective Enrichment of N-Glycopeptides in Amniotic Fluid., Shi Z, Pu L, Guo Y, Fu Z, Zhao W, Zhu Y*, Wu J*, Wang F*., 2017
Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c., Yin Y§, Gao L§, Lin H, Wu Y, Han X, Zhu Y*, Li J*., 2017
A Presenilin/Notch1 pathway regulated by miR-375, mR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis., Li Y, Zhang T, Zhou Y, Sun Y, Cao Y, Chang X, Zhu Y*, Han X*., 2016
Inhibition of tumor suppressor p53 preserves glycation-serum induced pancreatic beta-cell demise., Li Y, Zhang T, Huang Q, Sun Y, Chang X, Zhang H, Zhu Y*, Han X*., 2016
LXR activation causes G1/S arrest through inhibiting SKP2 expression in MIN6 pancreatic beta cells., Li Y, Jing C, Tang X, Chen Y, Han X, Zhu Y*., 2016
Type 2 diabetes mitigation in the diabetic Goto-Kakizaki rat by elevated bile acids following a common-bile-duct surgery., Feng G, Zhang X, Zhou L, Zhou S, Zheng Y, Yu J, Fan W, Zhu Y*, Han X*., 2016
MicroRNA-24/MODY Gene Regulatory Pathway Mediates Pancreatic Beta-Cell Dysfunction., Zhu Y*, You W, Wang H, Li Y, Qiao N, Shi Y, Zhang C, Bleich D, Han X., 2013
PPARγ activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability., Zhu Y*, Ma A, Zhang H, Li C., 2013
AGEs decrease insulin synthesis in pancreatic β-cell by repressing Pdx-1 protein expression at the post-translational level., Shu T*, Zhu Y*, Wang H, Lin Y, Ma Z, Han X., 2011
Inhibition of the receptor for advanced glycation endproducts (RAGE) protects pancreatic β-cells., Zhu Y*, Shu T, Lin Y, Wang H, Yang J, Shi Y, Han X., 2011
