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朱云霞
zhuyx@njmu.edu.cn
中文, 英文
江苏
南京医科大学
Basic Medical Sciences
  • 1999/9–2004/6 临床医学学士:南京医科大学
  • 2006/9–2009/12 病理学与病理生理学硕士:南京医科大学
  • 2010/9–2013/6 细胞生物学博士:南京师范大学
  • 发表SCI收录论文60余篇
  • 授权国家发明专利6项
  • 2004/7-2015/8 - 南京医科大学 - 江苏省人类功能基因组学重点实验室科研助理
  • 2015/9-2017/10 - 南京医科大学 - 基础医学讲师/博士后
  • 2017/11-2023/6 - 南京医科大学 - 生化与分子生物学系副研究员
  • 2023/7-至今 - 南京医科大学 - 生化与分子生物学系教授
  • 2016: 教育部高校自然科学奖,二等奖,胰岛β细胞功能相关分子的鉴定及作用机制研究
  • 2016: 江苏省科学技术进步奖,二等奖,内质网应激导致2型糖尿病胰岛β细胞功能障碍的分子机制
  • 2016: 江苏省教育科学成果奖,二等奖,内质网应激导致2型糖尿病胰岛β细胞功能障碍的分子机制
  • 2017: 南京市科技进步奖,三等奖,2型糖尿病发病的分子机制研究
  • 2007: 江苏省科学技术进步奖,二等奖,炎症因子导致糖尿病和胰岛β细胞功能损伤的机制研究
糖尿病中β细胞失代偿的表观遗传机制
  • The miR-203/ZBTB20/MAFA axis orchestrates pancreatic β-cell maturation and identity during weaning and diabetes., Li Y, Yang Y, Sun Y, He L, Zhao L, Sun H, Chang X, Liang R, Wang S, Han X*, and Zhu Y*., 2024
  • Inhibiting arachidonic acid generation mitigates aging-induced hyperinsulinemia and insulin resistance in mice., Xiao X, Yang L, Xiao L, Li Y, Chang X, Han X, Tang W*, Zhu Y*., 2024
  • Beta-cell MiRNA-503-5p Induced by Hypomethylation and Inflammation Promotes Insulin Resistance and β-Cell Decompensation., Zhou, Y., Liu, K., Tang, W., Zhang, Y., Sun, Y., Wu, Y., Shi, Y., Yao, Z., Li, Y., Bai, R., Liang, R., Sun, P., Chang, X., Wang, S., Zhu Y*, and Han X*., 2024
  • Islet-resident macrophage-derived miR-155 promotes β cell decompensation via targeting PDX1., Zhang Y, Cong R, Lv T, Liu K, Chang X, Li Y, Han X, Zhu Y*., 2024
  • Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreatic β-cell Dysfunction., Wang K, Wu S, Yao Z, Zhu Y*, Han X*., 2024
  • Polypeptide N-Acetylgalactosaminyl transferase 14 is a novel mediator in pancreatic β-cell function and growth., Shu T, Zhang Y, Sun T, Zhu Y*., 2024
  • BRSK2 in Pancreatic β Cells Promotes Hyperinsulinemia-Coupled Insulin Resistance and Its Genetic Variants are Associated with Human Type 2 Diabetes., Xu R, Wang K, Yao Z, Zhang Y, Jin L, Pang J, Zhou Y, Wang K, Liu D, Zhang YQ, Sun P, Wang F, Chang X, Liu T, Wang S, Zhang YL, Lin S, Hu C*, Zhu Y*, and Han X*., 2023
  • Rab31, a receptor of advanced glycation end products (RAGE) interacting protein, inhibits AGE induced pancreatic β-cell apoptosis through the pAKT/BCL2 pathway., Bai R, Zhang T, Gao Y, Shu T, Zhou Y, Wang F, Chang X, Tang W*, Zhu Y*, Han X., 2022
  • miR-25 and miR-92b regulate insulin biosynthesis and pancreatic β-cell apoptosis., Shen Z, Yu Y, Yang Y, Xiao X, Sun T, Chang X, Tang W*, Zhu Y*, Han X., 2022
  • Protocol for in vivo and ex vivo assessments of glucose-stimulated insulin secretion in mouse islet β cells., Zhu Y*, Zhou YC, Zhang Y, Sun P, Chang XA, Han X*., 2021
  • Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3., Sun Y, Zhou Y, Shi Y, Zhang Y, Liu K, Liang R, Sun P, Chang X, Tang W, Zhang Y, Li J, Wang S, Zhu Y*, Han X*., 2021
  • Inhibition of miR-153, an IL-1β-responsive miRNA, prevents beta cell failure and inflammation-associated diabetes., Sun Y, Zhou S, Shi Y, Zhou Y, Zhang Y, Liu K, Zhu Y*, Han X*., 2020
  • MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis., Zhu Y*, Sun Y, Zhou Y, Zhang Y, Zhang T, Li Y, You W, Chang X, Yuan L, Han X., 2019
  • Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic β-Cell Function and Survival., Huang Q, You W, Li Y, Sun Y, Zhou Y, Zhang Y, Liu D, Zhan S, Zhu Y*, Han X*., 2018
  • Mechanistic study of CBT-Cys click reaction and its application for identifying bioactive N-terminal cysteine peptides in amniotic fluid., Zheng Z*, Chen P*, Li G*, Zhu Y*, Shi Z, Luo Y, Zhao C, Fu Z, Cui X, Ji C, Wang F, Huang G, Liang G., 2017
  • Boronic Acid-Modified Magnetic Fe(3)O(4)@mTiO(2) Microspheres for Highly Sensitive and Selective Enrichment of N-Glycopeptides in Amniotic Fluid., Shi Z, Pu L, Guo Y, Fu Z, Zhao W, Zhu Y*, Wu J*, Wang F*., 2017
  • Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c., Yin Y§, Gao L§, Lin H, Wu Y, Han X, Zhu Y*, Li J*., 2017
  • A Presenilin/Notch1 pathway regulated by miR-375, mR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis., Li Y, Zhang T, Zhou Y, Sun Y, Cao Y, Chang X, Zhu Y*, Han X*., 2016
  • Inhibition of tumor suppressor p53 preserves glycation-serum induced pancreatic beta-cell demise., Li Y, Zhang T, Huang Q, Sun Y, Chang X, Zhang H, Zhu Y*, Han X*., 2016
  • LXR activation causes G1/S arrest through inhibiting SKP2 expression in MIN6 pancreatic beta cells., Li Y, Jing C, Tang X, Chen Y, Han X, Zhu Y*., 2016
  • Type 2 diabetes mitigation in the diabetic Goto-Kakizaki rat by elevated bile acids following a common-bile-duct surgery., Feng G, Zhang X, Zhou L, Zhou S, Zheng Y, Yu J, Fan W, Zhu Y*, Han X*., 2016
  • MicroRNA-24/MODY Gene Regulatory Pathway Mediates Pancreatic Beta-Cell Dysfunction., Zhu Y*, You W, Wang H, Li Y, Qiao N, Shi Y, Zhang C, Bleich D, Han X., 2013
  • PPARγ activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability., Zhu Y*, Ma A, Zhang H, Li C., 2013
  • AGEs decrease insulin synthesis in pancreatic β-cell by repressing Pdx-1 protein expression at the post-translational level., Shu T*, Zhu Y*, Wang H, Lin Y, Ma Z, Han X., 2011
  • Inhibition of the receptor for advanced glycation endproducts (RAGE) protects pancreatic β-cells., Zhu Y*, Shu T, Lin Y, Wang H, Yang J, Shi Y, Han X., 2011
表观遗传学 Β细胞 失代偿 糖尿病 代谢压力 胰岛素 基因表达 细胞机制 分子生物学 基因组学

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