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Juejin Wang
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: Chinese, English
Ion Channels
Cardiovascular
Diseases
Mechanism
Regulation
Membrane
Patch Clamp
Microvascular
Screening
Potential
Areas of Focus
- Ion channel diseases
- Role and mechanism of ion channels in cardiovascular diseases
Work Experience
- 2008-2010: Research Assistant, National Neuroscience Institute/National University of Singapore
- 2010-2012: Postdoctoral Researcher, National University of Singapore
- 2012-2019: Associate Professor, Department of Physiology, School of Basic Medicine, Nanjing Medical University
- 2016-2017: Postdoctoral Researcher, Cleveland Clinic, USA
- 2019-present: Professor, Department of Physiology, School of Basic Medicine, Nanjing Medical University
Academic Background & Achievements
- 2000-2005: Bachelor's degree in Clinical Medicine, Nanjing Medical University
- 2005-2010: PhD in Pharmacology, School of Basic Medicine, Nanjing Medical University
- Published over ten first/corresponding author papers in high-impact journals
- Led five National Natural Science Foundation projects
Publications
- Aberrant splicing of CaV1.2 calcium channel induced by decreased Rbfox1 enhances arterial constriction during diabetic hyperglycemia., Hou W, Yin S, Li P, Zhang L, Chen T, Qin D, Mustafa AU, Liu C, Song M, Qiu C, Xiong X*, Wang J*., 2024
- Dysregulated Rbfox2 produces aberrant splicing of CaV1.2 calcium channel in diabetes-induced cardiac hypertrophy., Li P, Qin D, Chen T, Hou W, Song X, Yin S, Song M, Fernando WCHA, Chen X, Sun Y*, Wang J*., 2023
- Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension., Song M, Hou W, Mustafa AU, Li P, Lei J, Zhou Y, Ji L, Sun Y, Zhou H*, Xu Y*, Wang J*., 2022
- A novel mutation in KCNH2 yields loss-of-function of hERG potassium channel in long QT syndrome 2., Gu K#, Qian D#, Qin H, Cui C, Fernando WCHA, Wang D, Wang J*, Cao K*, Chen M*., 2021
- Aberrant exon 8/8a splicing by downregulated PTBP (Polypyrimidine Tract-Binding Protein) 1 increases CaV1.2 dihydropyridine resistance to attenuate vasodilation., Lei J#, Liu X#, Song M, Zhou Y, Fan J, Shen X, Xu X, Kapoor I, Zhu G, Wang J*., 2020
- Galectin-1 attenuates cardiomyocyte hypertrophy through splice-variant specific modulation of CaV1.2 calcium channel., Fan J#, Fan W#, Lei J, Zhou Y, Xu H, Kapoor I, Zhu G, Wang J*., 2019
- Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia., Zhang Q#, Chen J#, Qin Y, Wang J*, Zhou L*., 2018
- Characterization of CaV1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and CaV1.2 exon 33 expressions in human heart failure., Wang J#, Li G#, Yu D, Wong YP, Yong TF, Liang MC, Liao P, Foo R, Hoppe UC, Soong TW*., 2018
- Aberrant splicing induced by dysregulated Rbfox2 produces enhanced function of CaV1.2 calcium channel and vascular myogenic tone in hypertension., Zhou Y#, Fan J#, Zhu H, Ji L, Fan W, Kapoor I, Wang Y, Wang Y, Zhu G, Wang J*., 2017
- Exclusion of alternative exon 33 of CaV1.2 calcium channels in heart is proarrhythmogenic., Li G#, Wang J#, Liao P, Bartels P, Zhang H, Yu D, Liang MC, Poh KK, Yu CY, Jiang F, Yong TF, Wong YP, Hu Z, Huang H, Zhang G, Galupo MJ, Bian JS, Ponniah S, Trasti SL, See K, Foo R, Hoppe UC, Herzig S, Soong TW*., 2017
- Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7., Ji L#, Zhu H#, Chen H, Fan W, Chen J, Chen J, Zhu G, Wang J*., 2015
- Splice variant specific modulation of CaV1.2 calcium channel by galectin-1 regulates arterial constriction., Wang J, Thio SS, Yang SS, Yu D, Yu CY, Wong YP, Liao P, Li S, Soong TW*., 2011
Awards
- 2018: Second Prize in Jiangsu Physiology Lecture Competition
- 2018: Second Prize in Youth Forum at Jiucheng International Cardiovascular Physiology Conference
- 2020: First Friendship Award of Nanjing Medical University
- 2021: Special Prize in the Second Teaching Innovation Competition of Nanjing Medical University
