Professor | Wei Gao | Asia Growth Partners

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Name	Wei Gao
Contact Information	gao@njmu.edu.cn
Language ability	Chinese, English
Province	Jiangsu

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Name

Wei Gao

Contact Information

gao@njmu.edu.cn

Language ability

Chinese, English

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1998.09 - 2002.06 Bachelor: Northeast Normal University 2004.09 - 2009.06 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences Published over 20 research papers in journals like Hepatology, Nature Communications, PNAS, and J Immunother Cancer Received 4 PCT patents and 8 national invention patents Awarded Jiangsu Higher Education Scientific Research Achievement Award
Work Experience	2011.03 - 2015.09 Postdoctoral Researcher: NIH/NCI, USA 2015.10 - Present Professor: Nanjing Medical University
Awards	Jiangsu Higher Education Scientific Research Achievement Award (2021): New mechanism of immune escape in inflammatory microenvironment promoting liver cancer progression and immune-targeted intervention strategy Jiangsu Province Sixth Phase '333 High-Level Talent Training Project' Third Level Training Object (2022)

University/Lab Affiliation and Title

Nanjing Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1998.09 - 2002.06 Bachelor: Northeast Normal University
2004.09 - 2009.06 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Published over 20 research papers in journals like Hepatology, Nature Communications, PNAS, and J Immunother Cancer
Received 4 PCT patents and 8 national invention patents
Awarded Jiangsu Higher Education Scientific Research Achievement Award

Work Experience

2011.03 - 2015.09 Postdoctoral Researcher: NIH/NCI, USA
2015.10 - Present Professor: Nanjing Medical University

Awards

Jiangsu Higher Education Scientific Research Achievement Award (2021): New mechanism of immune escape in inflammatory microenvironment promoting liver cancer progression and immune-targeted intervention strategy
Jiangsu Province Sixth Phase '333 High-Level Talent Training Project' Third Level Training Object (2022)

Areas of Focus	Antibody drugs and immune cell therapy for major diseases
Publications	Improving the cytotoxicity of immunotoxins by reducing the affinity of the antibody in acidic pH, Xiaoyu Liu, Qingqing Tan, Jiaqi Wen, Xufei Wang, Gang Yang, Yuxiao Li, Ming Lu, Wei Ye, Anfeng Si, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Mei Zhang, Tao Jiang, Wei Gao, 2023 Galectin-14 promotes hepatocellular carcinoma tumor growth via enhancing heparan sulfate proteoglycan modification, Gou Liming, Yang Gang, Ma Sujuan, Ding Tong, Sun Luan, Liu Fang, Huang Jin, Gao Wei, 2023 Improving antibody affinity through in vitro mutagenesis in complementarity determining regions, Ye Wei, Liu Xiaoyu, He Ruiting, Gou Liming, Lu Ming, Yang Gang, Wen Jiaqi, Wang Xufei, Liu Fang, Ma Sujuan, Qian Weifeng, Jia Shaochang, Ding Tong, Sun Luan, Gao Wei, 2022 Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in hepatocellular carcinoma, Sun L, Gao F, Gao Z, Ao L, Li N, Ma S, Jia M, Li N, Lu P, Sun B, Ho M, Jia S, Ding T, Gao W, 2021 32A9, a novel human antibody for designing an immunotoxin and CAR-T cells against glypican-3 in hepatocellular carcinoma, Liu X, Gao F, Jiang L, Jia M, Ao L, Lu M, Gou L, Ho M, Jia S, Chen F, Gao W, 2020 A Frizzled-Like Cysteine-Rich Domain in Glypican-3 Mediates Wnt Binding and Regulates Hepatocellular Carcinoma Tumor Growth in Mice, Li N, Wei L, Liu X, Bai H, Ye Y, Li D, Li N, Baxa U, Wang Q, Lv L, Chen Y, Feng M, Lee B, Gao W, Ho M, 2019 Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signaling and protein synthesis, Gao W, Tang Z, Zhang Y, Feng M, Qian M, Dimitrov D, Ho M, 2015 Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy, Gao W, Kim H, Feng M, Phung Y, Xavier C, Rubin J, Ho M, 2014

Areas of Focus

Antibody drugs and immune cell therapy for major diseases

Publications

Improving the cytotoxicity of immunotoxins by reducing the affinity of the antibody in acidic pH, Xiaoyu Liu, Qingqing Tan, Jiaqi Wen, Xufei Wang, Gang Yang, Yuxiao Li, Ming Lu, Wei Ye, Anfeng Si, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Mei Zhang, Tao Jiang, Wei Gao, 2023
Galectin-14 promotes hepatocellular carcinoma tumor growth via enhancing heparan sulfate proteoglycan modification, Gou Liming, Yang Gang, Ma Sujuan, Ding Tong, Sun Luan, Liu Fang, Huang Jin, Gao Wei, 2023
Improving antibody affinity through in vitro mutagenesis in complementarity determining regions, Ye Wei, Liu Xiaoyu, He Ruiting, Gou Liming, Lu Ming, Yang Gang, Wen Jiaqi, Wang Xufei, Liu Fang, Ma Sujuan, Qian Weifeng, Jia Shaochang, Ding Tong, Sun Luan, Gao Wei, 2022
Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in hepatocellular carcinoma, Sun L, Gao F, Gao Z, Ao L, Li N, Ma S, Jia M, Li N, Lu P, Sun B, Ho M, Jia S, Ding T, Gao W, 2021
32A9, a novel human antibody for designing an immunotoxin and CAR-T cells against glypican-3 in hepatocellular carcinoma, Liu X, Gao F, Jiang L, Jia M, Ao L, Lu M, Gou L, Ho M, Jia S, Chen F, Gao W, 2020
A Frizzled-Like Cysteine-Rich Domain in Glypican-3 Mediates Wnt Binding and Regulates Hepatocellular Carcinoma Tumor Growth in Mice, Li N, Wei L, Liu X, Bai H, Ye Y, Li D, Li N, Baxa U, Wang Q, Lv L, Chen Y, Feng M, Lee B, Gao W, Ho M, 2019
Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signaling and protein synthesis, Gao W, Tang Z, Zhang Y, Feng M, Qian M, Dimitrov D, Ho M, 2015
Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy, Gao W, Kim H, Feng M, Phung Y, Xavier C, Rubin J, Ho M, 2014

Antibody Immune Cell Therapy Major Diseases Tumor Metabolic Diseases Infectious Diseases Pathogenesis Gene Screening Antibody Design Therapy Optimization

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