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Wei Gao
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: Chinese, English
Antibody
Immune Cell Therapy
Major Diseases
Tumor
Metabolic Diseases
Infectious Diseases
Pathogenesis
Gene Screening
Antibody Design
Therapy Optimization
Areas of Focus
- Antibody drugs and immune cell therapy for major diseases
Work Experience
- 2011.03 - 2015.09 Postdoctoral Researcher: NIH/NCI, USA
- 2015.10 - Present Professor: Nanjing Medical University
Academic Background & Achievements
- 1998.09 - 2002.06 Bachelor: Northeast Normal University
- 2004.09 - 2009.06 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- Published over 20 research papers in journals like Hepatology, Nature Communications, PNAS, and J Immunother Cancer
- Received 4 PCT patents and 8 national invention patents
- Awarded Jiangsu Higher Education Scientific Research Achievement Award
Publications
- Improving the cytotoxicity of immunotoxins by reducing the affinity of the antibody in acidic pH, Xiaoyu Liu, Qingqing Tan, Jiaqi Wen, Xufei Wang, Gang Yang, Yuxiao Li, Ming Lu, Wei Ye, Anfeng Si, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Mei Zhang, Tao Jiang, Wei Gao, 2023
- Galectin-14 promotes hepatocellular carcinoma tumor growth via enhancing heparan sulfate proteoglycan modification, Gou Liming, Yang Gang, Ma Sujuan, Ding Tong, Sun Luan, Liu Fang, Huang Jin, Gao Wei, 2023
- Improving antibody affinity through in vitro mutagenesis in complementarity determining regions, Ye Wei, Liu Xiaoyu, He Ruiting, Gou Liming, Lu Ming, Yang Gang, Wen Jiaqi, Wang Xufei, Liu Fang, Ma Sujuan, Qian Weifeng, Jia Shaochang, Ding Tong, Sun Luan, Gao Wei, 2022
- Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in hepatocellular carcinoma, Sun L, Gao F, Gao Z, Ao L, Li N, Ma S, Jia M, Li N, Lu P, Sun B, Ho M, Jia S, Ding T, Gao W, 2021
- 32A9, a novel human antibody for designing an immunotoxin and CAR-T cells against glypican-3 in hepatocellular carcinoma, Liu X, Gao F, Jiang L, Jia M, Ao L, Lu M, Gou L, Ho M, Jia S, Chen F, Gao W, 2020
- A Frizzled-Like Cysteine-Rich Domain in Glypican-3 Mediates Wnt Binding and Regulates Hepatocellular Carcinoma Tumor Growth in Mice, Li N, Wei L, Liu X, Bai H, Ye Y, Li D, Li N, Baxa U, Wang Q, Lv L, Chen Y, Feng M, Lee B, Gao W, Ho M, 2019
- Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signaling and protein synthesis, Gao W, Tang Z, Zhang Y, Feng M, Qian M, Dimitrov D, Ho M, 2015
- Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy, Gao W, Kim H, Feng M, Phung Y, Xavier C, Rubin J, Ho M, 2014
Awards
- Jiangsu Higher Education Scientific Research Achievement Award (2021): New mechanism of immune escape in inflammatory microenvironment promoting liver cancer progression and immune-targeted intervention strategy
- Jiangsu Province Sixth Phase '333 High-Level Talent Training Project' Third Level Training Object (2022)
