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Yanchuan Li
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: Chinese, English
Signal Transduction
Immune Response
Molecular Mechanisms
B Cell Fate
Autoimmunity
Leukemogenesis
Nf-Κb Activation
Otub1
Traf3-Ewsr1
Nlrp3 Inflammasome
Areas of Focus
- Molecular mechanisms of key signal transduction pathways in immune response
Work Experience
- 2016-2021 - University of Texas MD Anderson Cancer Center - Postdoctoral Fellow
- 2021-2022 - University of Texas MD Anderson Cancer Center - Research Scientist
- 2022-2023 - Baylor College of Medicine - Associate Researcher
- 2023-present - Nanjing Medical University - Professor
Academic Background & Achievements
- 2012-2016 PhD: Peking Union Medical College
- Published 16 academic papers in international journals
Publications
- DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B cell leukemogenesis., Li, Yanchuan, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y Konopleva, Xuhong Cheng, Shao-Cong Sun, 2021
- Preventing Abnormal NF-κB Activation and Autoimmunity by Otub1-Mediated p100 Stabilization., Yanchuan Li, Jin-Young Yang, Xiaoping Xie, Zuliang Jie, Lingyun Zhang, Jianhong Shi, Daniel Lin, Meidi Gu, Xiaofei Zhou, Haiyan S Li, Stephanie S Watowich, Antrix Jain, Sung Yun Jung, Jun Qin, Xuhong Cheng, Shao-Cong Sun, 2019
- TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses., Yanchuan Li, Lele Zhu, Chun-Jung Ko, Jin-Young Yang, Ganiraju Manyam, Jing Wang, Xuhong Cheng, Shuli Zhao, Zuliang Jie, 2023
- TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis., Lele Zhu, Yanchuan Li, Xiaoping Xie, Xiaofei Zhou, Meidi Gu, Zuliang Jie, Chun-Jung Ko, Tianxiao Gao, Blanca E Hernandez, Xuhong Cheng, Shao-Cong Sun, 2019
- Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination., Lingyun Zhang, Chun-Jung Ko, Yanchuan Li, Zuliang Jie, Lele Zhu, Xiaofei Zhou, Xiaoping Xie, Tianxiao Gao, Ting Liu, Xuhong Cheng, Shao-Cong Sun, 2021
- Intestinal epithelial TBK1 prevents differentiation of T-helper 17 cells and tumorigenesis in mice., Jin-Young Yang, Zuliang Jie, Amber Mathews, Xiaofei Zhou, Yanchuan Li, Meidi Gu, Xiaoping Xie, Chun-Jung Ko, Xuhong Cheng, Yuan Qi, Jeannelyn S Estrella, Jing Wang, Shao-Cong Sun, 2020
- Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway., Zuliang Jie, Chun-Jung Ko, Hui Wang, Xiaoping Xie, Yanchuan Li, Meidi Gu, Lele Zhu, Jin-Young Yang, Tianxiao Gao, Wenjuan Ru, Shao-Jun Tang, Xuhong Cheng, Shao-Cong Sun, 2021
- Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer., Zhu, Lele, Xiaofei Zhou, Meidi Gu, Jiseong Kim, Yanchuan Li, Chun-Jung Ko, Xiaoping Xie, Tianxiao Gao, Xuhong Cheng, Shao-Cong Sun, 2022
- NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis., Zuliang Jie, Jin-Young Yang, Meidi Gu, Hui Wang, Xiaoping Xie, Yanchuan Li, Ting Liu, Lele Zhu, Jianhong Shi, Lingyun Zhang, Xiaofei Zhou, Donghyun Joo, Hans D Brightbill, Yingzi Cong, Daniel Lin, Xuhong Cheng, Shao-Cong Sun, 2018
- Myeloid cell TBK1 restricts inflammatory responses., Gao, Tianxiao, Ting Liu, Chun-Jung Ko, Lingyun Zhang, Donghyun Joo, Xiaoping Xie, Lele Zhu, Yanchuan Li, Xuhong Cheng, Shao-Cong Sun, 2022
