Professor | 李砚川 | 数字化转型顾问

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Name	李砚川
Contact Information	liyanchuan@njmu.edu.cn
Language ability	中文, 英语
Province	江苏

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Name

李砚川

Contact Information

liyanchuan@njmu.edu.cn

Language ability

中文, 英语

Province

江苏

University/Lab Affiliation and Title	南京医科大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	2012-2016 博士: 北京协和医学院在国际期刊上发表了16篇学术论文
Work Experience	2016-2021 - 美国德克萨斯大学MD安德森癌症中心 - 博士后 2021-2022 - 美国德克萨斯大学MD安德森癌症中心 - 研究科学家 2022-2023 - 美国贝勒医学院 - 副研究员 2023-至今 - 南京医科大学 - 教授

University/Lab Affiliation and Title

南京医科大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

2012-2016 博士: 北京协和医学院
在国际期刊上发表了16篇学术论文

Work Experience

2016-2021 - 美国德克萨斯大学MD安德森癌症中心 - 博士后
2021-2022 - 美国德克萨斯大学MD安德森癌症中心 - 研究科学家
2022-2023 - 美国贝勒医学院 - 副研究员
2023-至今 - 南京医科大学 - 教授

Areas of Focus	重要信号转导通路在免疫应答中的分子机理研究
Publications	DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B cell leukemogenesis., Li, Yanchuan, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y Konopleva, Xuhong Cheng, Shao-Cong Sun, 2021 Preventing Abnormal NF-κB Activation and Autoimmunity by Otub1-Mediated p100 Stabilization., Yanchuan Li, Jin-Young Yang, Xiaoping Xie, Zuliang Jie, Lingyun Zhang, Jianhong Shi, Daniel Lin, Meidi Gu, Xiaofei Zhou, Haiyan S Li, Stephanie S Watowich, Antrix Jain, Sung Yun Jung, Jun Qin, Xuhong Cheng, Shao-Cong Sun, 2019 TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses., Yanchuan Li, Lele Zhu, Chun-Jung Ko, Jin-Young Yang, Ganiraju Manyam, Jing Wang, Xuhong Cheng, Shuli Zhao, Zuliang Jie, 2023 TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis., Lele Zhu, Yanchuan Li, Xiaoping Xie, Xiaofei Zhou, Meidi Gu, Zuliang Jie, Chun-Jung Ko, Tianxiao Gao, Blanca E Hernandez, Xuhong Cheng, Shao-Cong Sun, 2019 Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination., Lingyun Zhang, Chun-Jung Ko, Yanchuan Li, Zuliang Jie, Lele Zhu, Xiaofei Zhou, Xiaoping Xie, Tianxiao Gao, Ting Liu, Xuhong Cheng, Shao-Cong Sun, 2021 Intestinal epithelial TBK1 prevents differentiation of T-helper 17 cells and tumorigenesis in mice., Jin-Young Yang, Zuliang Jie, Amber Mathews, Xiaofei Zhou, Yanchuan Li, Meidi Gu, Xiaoping Xie, Chun-Jung Ko, Xuhong Cheng, Yuan Qi, Jeannelyn S Estrella, Jing Wang, Shao-Cong Sun, 2020 Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway., Zuliang Jie, Chun-Jung Ko, Hui Wang, Xiaoping Xie, Yanchuan Li, Meidi Gu, Lele Zhu, Jin-Young Yang, Tianxiao Gao, Wenjuan Ru, Shao-Jun Tang, Xuhong Cheng, Shao-Cong Sun, 2021 Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer., Zhu, Lele, Xiaofei Zhou, Meidi Gu, Jiseong Kim, Yanchuan Li, Chun-Jung Ko, Xiaoping Xie, Tianxiao Gao, Xuhong Cheng, Shao-Cong Sun, 2022 NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis., Zuliang Jie, Jin-Young Yang, Meidi Gu, Hui Wang, Xiaoping Xie, Yanchuan Li, Ting Liu, Lele Zhu, Jianhong Shi, Lingyun Zhang, Xiaofei Zhou, Donghyun Joo, Hans D Brightbill, Yingzi Cong, Daniel Lin, Xuhong Cheng, Shao-Cong Sun, 2018 Myeloid cell TBK1 restricts inflammatory responses., Gao, Tianxiao, Ting Liu, Chun-Jung Ko, Lingyun Zhang, Donghyun Joo, Xiaoping Xie, Lele Zhu, Yanchuan Li, Xuhong Cheng, Shao-Cong Sun, 2022

Areas of Focus

重要信号转导通路在免疫应答中的分子机理研究

Publications

DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B cell leukemogenesis., Li, Yanchuan, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y Konopleva, Xuhong Cheng, Shao-Cong Sun, 2021
Preventing Abnormal NF-κB Activation and Autoimmunity by Otub1-Mediated p100 Stabilization., Yanchuan Li, Jin-Young Yang, Xiaoping Xie, Zuliang Jie, Lingyun Zhang, Jianhong Shi, Daniel Lin, Meidi Gu, Xiaofei Zhou, Haiyan S Li, Stephanie S Watowich, Antrix Jain, Sung Yun Jung, Jun Qin, Xuhong Cheng, Shao-Cong Sun, 2019
TRAF3-EWSR1 signaling axis acts as a checkpoint on germinal center responses., Yanchuan Li, Lele Zhu, Chun-Jung Ko, Jin-Young Yang, Ganiraju Manyam, Jing Wang, Xuhong Cheng, Shuli Zhao, Zuliang Jie, 2023
TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis., Lele Zhu, Yanchuan Li, Xiaoping Xie, Xiaofei Zhou, Meidi Gu, Zuliang Jie, Chun-Jung Ko, Tianxiao Gao, Blanca E Hernandez, Xuhong Cheng, Shao-Cong Sun, 2019
Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination., Lingyun Zhang, Chun-Jung Ko, Yanchuan Li, Zuliang Jie, Lele Zhu, Xiaofei Zhou, Xiaoping Xie, Tianxiao Gao, Ting Liu, Xuhong Cheng, Shao-Cong Sun, 2021
Intestinal epithelial TBK1 prevents differentiation of T-helper 17 cells and tumorigenesis in mice., Jin-Young Yang, Zuliang Jie, Amber Mathews, Xiaofei Zhou, Yanchuan Li, Meidi Gu, Xiaoping Xie, Chun-Jung Ko, Xuhong Cheng, Yuan Qi, Jeannelyn S Estrella, Jing Wang, Shao-Cong Sun, 2020
Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway., Zuliang Jie, Chun-Jung Ko, Hui Wang, Xiaoping Xie, Yanchuan Li, Meidi Gu, Lele Zhu, Jin-Young Yang, Tianxiao Gao, Wenjuan Ru, Shao-Jun Tang, Xuhong Cheng, Shao-Cong Sun, 2021
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer., Zhu, Lele, Xiaofei Zhou, Meidi Gu, Jiseong Kim, Yanchuan Li, Chun-Jung Ko, Xiaoping Xie, Tianxiao Gao, Xuhong Cheng, Shao-Cong Sun, 2022
NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis., Zuliang Jie, Jin-Young Yang, Meidi Gu, Hui Wang, Xiaoping Xie, Yanchuan Li, Ting Liu, Lele Zhu, Jianhong Shi, Lingyun Zhang, Xiaofei Zhou, Donghyun Joo, Hans D Brightbill, Yingzi Cong, Daniel Lin, Xuhong Cheng, Shao-Cong Sun, 2018
Myeloid cell TBK1 restricts inflammatory responses., Gao, Tianxiao, Ting Liu, Chun-Jung Ko, Lingyun Zhang, Donghyun Joo, Xiaoping Xie, Lele Zhu, Yanchuan Li, Xuhong Cheng, Shao-Cong Sun, 2022

信号转导免疫应答分子机理 B细胞命运自身免疫白血病发生 Nf-Κb激活 Otub1 Traf3-Ewsr1 Nlrp3炎症小体

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