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Lei Cao
Basic Medical Sciences
Nanjing Medical University
Jiangsu
Language: Chinese, English
Parkinson'S Disease
Pathological Mechanisms
Drug Targets
Neurodegenerative Diseases
Neuroinflammation
Autophagy
Alpha-Synuclein
Na(+)/K(+)-Atpase
Immunotherapy
Pharmacology
Areas of Focus
- Pathological mechanisms of Parkinson's disease and drug target discovery
Work Experience
- 2016-08 to 2018-07 - National University of Singapore - Assistant Researcher
- 2022-01 to Present - Nanjing Medical University - Associate Professor, Master's Supervisor
Academic Background & Achievements
- 2007-09 to 2012-07 Bachelor's in Clinical Medicine: Nanjing Medical University
- 2012-09 to 2015-07 Master's in Pharmacology: Nanjing Medical University
- 2018-08 to 2021-05 PhD in Pharmacology: National University of Singapore
Publications
- Anti-Na(+)/K(+)-ATPase immunotherapy ameliorates alpha-synuclein pathology through activation of Na(+)/K(+)-ATPase alpha1-dependent autophagy., Cao, L., Xiong, S., Wu, Z., Ding, L., Zhou, Y., Sun, H., Zhu, M., Lee, W. T., Nie, X., & Bian, J. S., 2021
- Hydrogen sulfide inhibits ATP-induced neuroinflammation and Abeta(1-42) synthesis by suppressing the activation of STAT3 and cathepsin S., Cao, L., Cao, X., Zhou, Y., Nagpure, B. V., Wu, Z. Y., Hu, L. F., Yang, Y., Sethi, G., Moore, P. K., & Bian, J. S., 2018
- Therapeutic potential of sulfur-containing natural products in inflammatory diseases., Cao, X., Cao, L., Zhang, W., Lu, R., Bian, J. S., & Nie, X., 2020
- DR-region of Na(+)/K(+) ATPase is a target to treat excitotoxicity and stroke., Shi, M., Cao, L., Cao, X., Zhu, M., Zhang, X., Wu, Z., Xiong, S., Xie, Z., Yang, Y., Chen, J., Wong, P. T. H., & Bian, J. S., 2018
- Mitochondrial glutamine transporter SLC1A5_var, a potential target to suppress astrocyte reactivity in Parkinson's Disease., Liu, Y., Cao, L., Song, Y., Kang, Z., Liu, T., Ding, J., Hu, G., & Lu, M., 2022
