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Liang Zhao
liangsmu@foxmail.com
Chinese, English
Guangdong
Southern Medical University
Basic Medical Sciences
  • Guangdong Pearl River Scholar Distinguished Professor (2019): Guangdong Education Department
  • Guangdong Science and Technology Progress First Prize (2013): Guangdong Science and Technology Department
  • Chinese Medical Science Second Prize (2013): Chinese Medical Association
  • Guangdong Natural Science Outstanding Youth Fund Recipient (2012): Guangdong Science and Technology Department
  • Guangdong Special Support Plan for Science and Technology Innovation Young Top Talent (2014): Guangdong Science and Technology Department
  • Guangdong 'Thousand Hundred Ten Talent Project' Provincial Training Object (2012): Guangdong Education Department
  • China Pathology Research Outstanding Youth Award (2011): Chinese Medical Association
  • National Excellent Doctoral Dissertation (2010): Ministry of Education
Molecular mechanisms of gastrointestinal tumor metastasis
Tumor microenvironment and targeted therapy
Tumor metabolism and tumor progression
  • Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer., Li R, Zhou R, Wang H, Li W, Pan M, Yao X, Zhan W, Yang S, Xu L, Ding Y, Zhao L, 2019
  • LIM and SH3 protein 1 induces TGFbeta-mediated epithelial-mesenchymal transition in human colorectal cancer by regulating S100A4 expression., Wang H, Shi J, Luo Y, Liao Q, Niu Y, Zhang F, Shao Z, Ding Y, Zhao L, 2014
  • Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1., Zhao L, Wang H, Liu C, Liu Y, Wang X, Wang S, Sun X, Li J, Deng Y, Jiang Y, Ding Y, 2010
  • Long noncoding RNA CRCMSL suppresses tumor invasive and metastasis in colorectal carcinoma through nucleocytoplasmic shuttling of HMGB2., Han Q, Xu L, Lin W, Yao X, Jiang M, Zhou R, Sun X, Zhao L, 2019
  • Long Noncoding RNA CMPK2 Promotes Colorectal Cancer Progression by Activating the FUBP3-c-Myc Axis., Qingzu Gao, Rui Zhou, Yuan Meng, Rongfei Duan, Ling Wu, Rui Li, Fengliu Deng, Chuang Lin, Liang Zhao, 2020
  • Tumor-secreted dickkopf2 accelerates aerobic glycolysis and promotes angiogenesis in colorectal cancer., Fengliu Deng, Rui Zhou, Chuang Lin, Shibin Yang, Hui Wang, Weidong Li, Kehong Zheng, Wandie Lin, Xin Li, Xueqing Yao, Mingxin Pan, Zhao L, 2019
  • Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1., Tang Y, Lu Y, Chen Y, Luo L, Cai L, Peng B, Huang W, Liao H, Zhao L, Pan M, 2019
  • Cysteine-rich intestinal protein 1 suppresses apoptosis and chemosensitivity to 5-fluorouracil in colorectal cancer through ubiquitin-mediated Fas degradation., Lanzhi Zhang, Rui Zhou, Weibin Zhang, Xueqing Yao, Weidong Li, Lijun Xu, Xuegang Sun, Liang Zhao, 2019
  • LIM kinase 1 interacts with myosin-9 and alpha-actinin-4 and promotes colorectal cancer progression., Liao Q, Li R, Zhou R, Pan Z, Xu L, Ding Y, Zhao L, 2017
  • COPS5 and LASP1 Synergistically Interact to Down Regulate 14-3-3σ Expression and Promote Colorectal Cancer Progression via Activating PI3K/AKT Pathway., Rui Zhou, Ziyun Shao, Jian Liu, Wanqi Zhan, Qingzu Gao, Zhihua Pan, Ling Wu, Lijun Xu, Yanqing Ding, Liang Zhao, 2018
  • Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis., Zeng Z, Li Y, Pan Y, Lan X, Song F, Sun J, Zhou K, Liu X, Ren X, Wang F, Hu J, Zhu X, Yang W, Liao W, Li G, Ding Y, Liang Z, 2018
  • CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer., Hu JL, Wang W, Lan XL, Zeng ZC, Liang YS, Yan YR, Song FY, Wang FF, Zhu XH, Liao WJ, Liao WT, Ding YQ, Liang Z, 2019
  • FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal cancer., Wang FF, Zhang XJ, Yan YR, Zhu XH, Yu J, Ding Y, Hu JL, Zhou WJ, Zeng ZC, Liao WT, Ding YQ, Liang Z, 2017
  • Down-regulation of DAB2IP promotes colorectal cancer invasion and metastasis by translocating hnRNPK into nucleus to enhance the transcription of MMP2., Not mentioned
  • FMNL2 destabilizes COMMD10 to activate NF-κB pathway in invasion and metastasis of colorectal cancer., Not mentioned, 2017
  • Inhibition of ATG12-mediated autophagy by miR-214 enhances radiosensitivity in colorectal cancer., Not mentioned, 2018
  • Cortactin recruits FMNL2 to promote actin polymerization and endosome motility in invadopodia formation., Not mentioned, 2018
  • FBX8 degrades GSTP1 through ubiquitination to suppress colorectal cancer progression., Not mentioned, 2019
  • KNK437 restricts the growth and metastasis of colorectal cancer via targeting DNAJA1/CDC45 axis., Not mentioned, 2020
  • CD24 and PRAME are novel grading and prognostic indicators for pineal parenchymal tumors of intermediate differentiation., Not mentioned, 2020
  • GFTP2 promotes metastasis and forms a positive feedback loop with p65 in colorectal cancer., Not mentioned, 2020
  • FBX8 promotes metastatic dormancy of colorectal cancer in liver., Not mentioned, 2020
  • Inhibition of CCL7 derived from Mo-MDSCs prevents metastatic progression from latency in colorectal cancer., Not mentioned, 2021
  • CMTM6 expression in M2 macrophages is a biomarker for predicting the response of PD1/PD-L1 inhibitors in colorectal cancer., Not mentioned, 2021
Tumor Metastasis Colorectal Cancer Liver Cancer Tumor Microenvironment Tumor Immunity Tumor Metabolism Chemotherapy Resistance Gastrointestinal Tumors Molecular Mechanisms Targeted Therapy

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