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Zhenye Yang
Basic Medical Sciences
University of Science and Technology of China
Anhui
Language: English, Chinese
Aneuploidy
Tumor
Cell Division
Immune Regulation
Metabolic Regulation
Chemotherapy Resistance
Targeted Therapy
Immunotherapy
Malignant Tumors
Cell Cycle
Areas of Focus
- Aneuploid tumor cell division and its immune and metabolic regulation
- Mechanisms of tumor chemotherapy resistance, combined targeted therapy and new strategies for immunotherapy
- Regulation of cell division and its relationship with the occurrence and development of malignant tumors
Work Experience
- 2005-2012 - Postdoctoral Research: Wadsworth Center, State University of New York and National Cancer Institute, USA
- 2013-present - Professor: School of Life Sciences and Medicine, University of Science and Technology of China
- 2019-present - Specially Appointed Professor: The First Affiliated Hospital of University of Science and Technology of China
Academic Background & Achievements
- 1999 - Bachelor of Science: Shanghai Jiao Tong University
- 2005 - PhD in Cell Biology: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Publications
- A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells., Cheng A, Xu T, You W, Wang T, Zhang D, Guo H, Zhang H, Pan X, Wang Y, Liu L, Zhang K, Shi J, Yao X, Guo J, Yang Z., 2023
- Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression., Jiang Y, Wang T, Sheng D, Han C, Xu T, Zhang P, You W, Fan W, Zhang Z, Jin T, Duan X, Yuan X, Liu X, Zhang K, Ruan K, Shi J, Guo J, Cheng A, Yang Z., 2022
- Energy restriction causes metaphase delay and chromosome mis-segregation in cancer cells., Cheng A, Jiang Y, Wang T, Yu F, Ishrat I, Zhang D, Ji X, Chen M, Xiao W, Li Q, Zhang K, Niu G, Shi J, Pan Y, Yang Z, Guo J., 2021
- Aurora-A Mediated Phosphorylation of Lactate Dehydrogenase B promotes glycolysis and tumor growth by relieving the substrate inhibition effect., Cheng A, Zhang P, Wang B, Yang D, Duan X, Jiang Y, Xu T, Jiang Y, Shi J, Ding C, Wu G, Sang Z, Wu Q, Wang H, Wu M, Zhang Z, Pan X, Pan Y, Gao P, Zhang H, Zhou C, Guo J, Yang Z., 2019
- Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer., Yin T, Zhao ZB, Guo J, Wang T, Yang JB, Wang C, Long J, Ma S, Huang Q, Zhang K, Ma X, Liu C, Liu S, Lian ZX, Yang Z., 2019
- Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B Feedback Loop in late G2 phase., Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J, Yang Z., 2017
- Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway., Ma X, Wang L, Huang, Li Y, Yang D, Li T, Li F, Sun L, Wei H, He K, Yu F, Zhao D, Hu L, Xing S, Liu Z, Li K, Guo J, Yang Z, Pan X, Li A, Shi Y, Wang J, Gao P, Zhang H., 2017
- Misfolded Gbeta2 is recruited to cytoplasmic dynein by Nudel for efficient clearance., Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, Zhu X., 2012
- Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments., Yang Z., Kenny A., Brito D., Rieder C., 2009
- Extra centrosomes and/or chromosomes prolong mitosis in human cells., Yang Z., Loncarek J., Khodjakov A., Rieder C., 2008
- Microtubules do not promote mitotic slippage when the Spindle Assembly Checkpoint cannot be satisfied., Brito D., Yang Z., Rieder C., 2008
- Kinetochore Dynein is Required for Normal Chromosome Motion and Congression Independent of the Spindle Checkpoint., Yang Z., Tulu S., Wadsworth P., Rieder C., 2007
- Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly., Guo J., Yang Z., Song W., Chen Q., Wang F., Zhang Q., Zhu X., 2006
- Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death., Yang Z., Guo J., Chen Q., Du J., Ding C., Zhu X., 2005
- Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport., Yang Z., Guo J., Li N., Qian M., Wang S, Zhu X., 2003
Awards
- 2012 - Selected for the National Innovative Talent Youth Project
