Professor | Zhenye Yang | Asia Growth Partners

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Name	Zhenye Yang
Contact Information	zhenye(at)ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Zhenye Yang

Contact Information

zhenye(at)ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Basic Medical Sciences
Academic Background & Achievements	1999 - Bachelor of Science: Shanghai Jiao Tong University 2005 - PhD in Cell Biology: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Work Experience	2005-2012 - Postdoctoral Research: Wadsworth Center, State University of New York and National Cancer Institute, USA 2013-present - Professor: School of Life Sciences and Medicine, University of Science and Technology of China 2019-present - Specially Appointed Professor: The First Affiliated Hospital of University of Science and Technology of China
Awards	2012 - Selected for the National Innovative Talent Youth Project

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Basic Medical Sciences

Academic Background & Achievements

1999 - Bachelor of Science: Shanghai Jiao Tong University
2005 - PhD in Cell Biology: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

Work Experience

2005-2012 - Postdoctoral Research: Wadsworth Center, State University of New York and National Cancer Institute, USA
2013-present - Professor: School of Life Sciences and Medicine, University of Science and Technology of China
2019-present - Specially Appointed Professor: The First Affiliated Hospital of University of Science and Technology of China

Awards

2012 - Selected for the National Innovative Talent Youth Project

Areas of Focus	Aneuploid tumor cell division and its immune and metabolic regulation Mechanisms of tumor chemotherapy resistance, combined targeted therapy and new strategies for immunotherapy Regulation of cell division and its relationship with the occurrence and development of malignant tumors
Publications	A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells., Cheng A, Xu T, You W, Wang T, Zhang D, Guo H, Zhang H, Pan X, Wang Y, Liu L, Zhang K, Shi J, Yao X, Guo J, Yang Z., 2023 Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression., Jiang Y, Wang T, Sheng D, Han C, Xu T, Zhang P, You W, Fan W, Zhang Z, Jin T, Duan X, Yuan X, Liu X, Zhang K, Ruan K, Shi J, Guo J, Cheng A, Yang Z., 2022 Energy restriction causes metaphase delay and chromosome mis-segregation in cancer cells., Cheng A, Jiang Y, Wang T, Yu F, Ishrat I, Zhang D, Ji X, Chen M, Xiao W, Li Q, Zhang K, Niu G, Shi J, Pan Y, Yang Z, Guo J., 2021 Aurora-A Mediated Phosphorylation of Lactate Dehydrogenase B promotes glycolysis and tumor growth by relieving the substrate inhibition effect., Cheng A, Zhang P, Wang B, Yang D, Duan X, Jiang Y, Xu T, Jiang Y, Shi J, Ding C, Wu G, Sang Z, Wu Q, Wang H, Wu M, Zhang Z, Pan X, Pan Y, Gao P, Zhang H, Zhou C, Guo J, Yang Z., 2019 Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer., Yin T, Zhao ZB, Guo J, Wang T, Yang JB, Wang C, Long J, Ma S, Huang Q, Zhang K, Ma X, Liu C, Liu S, Lian ZX, Yang Z., 2019 Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B Feedback Loop in late G2 phase., Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J, Yang Z., 2017 Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway., Ma X, Wang L, Huang, Li Y, Yang D, Li T, Li F, Sun L, Wei H, He K, Yu F, Zhao D, Hu L, Xing S, Liu Z, Li K, Guo J, Yang Z, Pan X, Li A, Shi Y, Wang J, Gao P, Zhang H., 2017 Misfolded Gbeta2 is recruited to cytoplasmic dynein by Nudel for efficient clearance., Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, Zhu X., 2012 Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments., Yang Z., Kenny A., Brito D., Rieder C., 2009 Extra centrosomes and/or chromosomes prolong mitosis in human cells., Yang Z., Loncarek J., Khodjakov A., Rieder C., 2008 Microtubules do not promote mitotic slippage when the Spindle Assembly Checkpoint cannot be satisfied., Brito D., Yang Z., Rieder C., 2008 Kinetochore Dynein is Required for Normal Chromosome Motion and Congression Independent of the Spindle Checkpoint., Yang Z., Tulu S., Wadsworth P., Rieder C., 2007 Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly., Guo J., Yang Z., Song W., Chen Q., Wang F., Zhang Q., Zhu X., 2006 Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death., Yang Z., Guo J., Chen Q., Du J., Ding C., Zhu X., 2005 Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport., Yang Z., Guo J., Li N., Qian M., Wang S, Zhu X., 2003

Areas of Focus

Aneuploid tumor cell division and its immune and metabolic regulation
Mechanisms of tumor chemotherapy resistance, combined targeted therapy and new strategies for immunotherapy
Regulation of cell division and its relationship with the occurrence and development of malignant tumors

Publications

A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells., Cheng A, Xu T, You W, Wang T, Zhang D, Guo H, Zhang H, Pan X, Wang Y, Liu L, Zhang K, Shi J, Yao X, Guo J, Yang Z., 2023
Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression., Jiang Y, Wang T, Sheng D, Han C, Xu T, Zhang P, You W, Fan W, Zhang Z, Jin T, Duan X, Yuan X, Liu X, Zhang K, Ruan K, Shi J, Guo J, Cheng A, Yang Z., 2022
Energy restriction causes metaphase delay and chromosome mis-segregation in cancer cells., Cheng A, Jiang Y, Wang T, Yu F, Ishrat I, Zhang D, Ji X, Chen M, Xiao W, Li Q, Zhang K, Niu G, Shi J, Pan Y, Yang Z, Guo J., 2021
Aurora-A Mediated Phosphorylation of Lactate Dehydrogenase B promotes glycolysis and tumor growth by relieving the substrate inhibition effect., Cheng A, Zhang P, Wang B, Yang D, Duan X, Jiang Y, Xu T, Jiang Y, Shi J, Ding C, Wu G, Sang Z, Wu Q, Wang H, Wu M, Zhang Z, Pan X, Pan Y, Gao P, Zhang H, Zhou C, Guo J, Yang Z., 2019
Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer., Yin T, Zhao ZB, Guo J, Wang T, Yang JB, Wang C, Long J, Ma S, Huang Q, Zhang K, Ma X, Liu C, Liu S, Lian ZX, Yang Z., 2019
Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B Feedback Loop in late G2 phase., Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J, Yang Z., 2017
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway., Ma X, Wang L, Huang, Li Y, Yang D, Li T, Li F, Sun L, Wei H, He K, Yu F, Zhao D, Hu L, Xing S, Liu Z, Li K, Guo J, Yang Z, Pan X, Li A, Shi Y, Wang J, Gao P, Zhang H., 2017
Misfolded Gbeta2 is recruited to cytoplasmic dynein by Nudel for efficient clearance., Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, Zhu X., 2012
Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments., Yang Z., Kenny A., Brito D., Rieder C., 2009
Extra centrosomes and/or chromosomes prolong mitosis in human cells., Yang Z., Loncarek J., Khodjakov A., Rieder C., 2008
Microtubules do not promote mitotic slippage when the Spindle Assembly Checkpoint cannot be satisfied., Brito D., Yang Z., Rieder C., 2008
Kinetochore Dynein is Required for Normal Chromosome Motion and Congression Independent of the Spindle Checkpoint., Yang Z., Tulu S., Wadsworth P., Rieder C., 2007
Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly., Guo J., Yang Z., Song W., Chen Q., Wang F., Zhang Q., Zhu X., 2006
Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death., Yang Z., Guo J., Chen Q., Du J., Ding C., Zhu X., 2005
Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport., Yang Z., Guo J., Li N., Qian M., Wang S, Zhu X., 2003

Aneuploidy Tumor Cell Division Immune Regulation Metabolic Regulation Chemotherapy Resistance Targeted Therapy Immunotherapy Malignant Tumors Cell Cycle

Zhenye Yang - University of Science and Technology of China

Genze Shao - Peking University

Yin Yuxin - Peking University

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