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Yin Yuxin
Basic Medical Sciences
Peking University
Beijing
Language: English, Chinese
Tumor Suppressor Genes
Cell Cycle
Apoptosis
Genomic Stability
Cellular Metabolism
Tumor Immunity
Immunotherapy
Metabolomics
Early Diagnosis
Brain Cognition
Areas of Focus
- Role of tumor suppressor genes in cell cycle regulation, apoptosis, genomic stability, and cellular metabolism
- Mechanisms of tumor immunity and immunotherapy
- Metabolomics studies and early diagnosis of tumors
- Mechanisms of brain cognition and memory
Work Experience
- 1999 - Present: Professor at Columbia University, USA
- 2008 - Present: Shu Fan Chair Professor at Peking University
- 2015 - Present: Lin Songnian Foundation Chair Professor at Peking University
Academic Background & Achievements
- 1997 - PhD in Molecular Biology and Genetics from University of North Carolina, USA
- Postdoctoral research at Princeton University
- Published over 160 SCI papers
Publications
- PAC1 phosphatase is a transcription target of p53 in signaling apoptosis and growth suppression, Yin, Y.*, Liu, Y. X., Jin, Y. J., Hall, E. J., and Barrett, J. C., 2003
- Essential role for nuclear PTEN in maintaining chromosomal integrity, Shen, W. H., Balajee, A. B., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., and Yin, Y.*, 2007
- PTENα is a PTEN isoform Translated through Alternative Initiation and Regulates Mitochondrial Function, Liang, H., He, S., Yang, J., Jia, X., Wang, P., Chen, X., Zhang, Z., Zou, X., McNutt, M.A., Shen, W.H.,* and Yin, Y.*, 2014
- The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation, Lu, D., Liu, L., Ji, X., Gao, Y., Chen, X., Liu, Y., Liu, Y., Zhao, X., Li, Y., Li, Y., Jin, Y., Zhang, Y., McNutt, M.A., Zhang, Y., and Yin, Y.*, 2015
- The phosphatase pac1 acts as a t cell suppressor and attenuates host antitumor immunity, Lu, D., Liu, L., Sun, Y., Song, J., Yin, Q., Zhang, G., Qi, F., Hu, Z., Yang, Z., Zhou, Z., Hu, Y., Zhang, L., Ji, J., Zhao, X., Jin, Y., McNutt, M. A., Yin, Y*., 2020
- Systematic analyses of early-stage lung cancer by scRNA-seq and lipidomic reveal aberrant lipid metabolism as detection biomarkers, Wang, G., Qiu, M., Xing, X., Zhou, J., Yao, H., Li, M., Yin, R., Hou, Y., Li, Y., Pan, S., Huang, Y., Yang, F., Bai, F., Nie, H., Di, S., Guo, L., Meng, Z., Wang, J., Yin, Y*., 2022
Awards
- 2017: Second Prize of the Chinese Medical Science and Technology Award
