Professor | 杨振业 | 数字化转型顾问

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Name	杨振业
Contact Information	{'en': 'zhenye(at)ustc.edu.cn', 'zh': 'zhenye(at)ustc.edu.cn', 'de': 'zhenye(at)ustc.edu.cn'}
Language ability	英语, 中文
Province	安徽

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Name

杨振业

Contact Information

{'en': 'zhenye(at)ustc.edu.cn', 'zh': 'zhenye(at)ustc.edu.cn', 'de': 'zhenye(at)ustc.edu.cn'}

Language ability

英语, 中文

Province

安徽

University/Lab Affiliation and Title	中国科学技术大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	1999年 - 理学学士: 上海交通大学 2005年 - 细胞生物学博士: 中国科学院上海生物化学与细胞生物学研究所
Work Experience	2005-2012年 - 博士后研究: 美国纽约州立大学Wadsworth研究中心和美国国家癌症研究所 2013年至今 - 教授: 中国科学技术大学生命科学与医学部 2019年至今 - 特任教授: 中国科学技术大学附属第一医院
Awards	2012年 - 入选国家创新人才青年项目

University/Lab Affiliation and Title

中国科学技术大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

1999年 - 理学学士: 上海交通大学
2005年 - 细胞生物学博士: 中国科学院上海生物化学与细胞生物学研究所

Work Experience

2005-2012年 - 博士后研究: 美国纽约州立大学Wadsworth研究中心和美国国家癌症研究所
2013年至今 - 教授: 中国科学技术大学生命科学与医学部
2019年至今 - 特任教授: 中国科学技术大学附属第一医院

Awards

2012年 - 入选国家创新人才青年项目

Areas of Focus	非整倍肿瘤细胞分裂及其免疫和代谢调控肿瘤化疗耐药机理，联合靶向治疗和免疫治疗新策略细胞分裂调控与恶性肿瘤发生、发展的关系
Publications	A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells., Cheng A, Xu T, You W, Wang T, Zhang D, Guo H, Zhang H, Pan X, Wang Y, Liu L, Zhang K, Shi J, Yao X, Guo J, Yang Z., 2023 Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression., Jiang Y, Wang T, Sheng D, Han C, Xu T, Zhang P, You W, Fan W, Zhang Z, Jin T, Duan X, Yuan X, Liu X, Zhang K, Ruan K, Shi J, Guo J, Cheng A, Yang Z., 2022 Energy restriction causes metaphase delay and chromosome mis-segregation in cancer cells., Cheng A, Jiang Y, Wang T, Yu F, Ishrat I, Zhang D, Ji X, Chen M, Xiao W, Li Q, Zhang K, Niu G, Shi J, Pan Y, Yang Z, Guo J., 2021 Aurora-A Mediated Phosphorylation of Lactate Dehydrogenase B promotes glycolysis and tumor growth by relieving the substrate inhibition effect., Cheng A, Zhang P, Wang B, Yang D, Duan X, Jiang Y, Xu T, Jiang Y, Shi J, Ding C, Wu G, Sang Z, Wu Q, Wang H, Wu M, Zhang Z, Pan X, Pan Y, Gao P, Zhang H, Zhou C, Guo J, Yang Z., 2019 Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer., Yin T, Zhao ZB, Guo J, Wang T, Yang JB, Wang C, Long J, Ma S, Huang Q, Zhang K, Ma X, Liu C, Liu S, Lian ZX, Yang Z., 2019 Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B Feedback Loop in late G2 phase., Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J, Yang Z., 2017 Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway., Ma X, Wang L, Huang, Li Y, Yang D, Li T, Li F, Sun L, Wei H, He K, Yu F, Zhao D, Hu L, Xing S, Liu Z, Li K, Guo J, Yang Z, Pan X, Li A, Shi Y, Wang J, Gao P, Zhang H., 2017 Misfolded Gbeta2 is recruited to cytoplasmic dynein by Nudel for efficient clearance., Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, Zhu X., 2012 Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments., Yang Z., Kenny A., Brito D., Rieder C., 2009 Extra centrosomes and/or chromosomes prolong mitosis in human cells., Yang Z., Loncarek J., Khodjakov A., Rieder C., 2008 Microtubules do not promote mitotic slippage when the Spindle Assembly Checkpoint cannot be satisfied., Brito D., Yang Z., Rieder C., 2008 Kinetochore Dynein is Required for Normal Chromosome Motion and Congression Independent of the Spindle Checkpoint., Yang Z., Tulu S., Wadsworth P., Rieder C., 2007 Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly., Guo J., Yang Z., Song W., Chen Q., Wang F., Zhang Q., Zhu X., 2006 Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death., Yang Z., Guo J., Chen Q., Du J., Ding C., Zhu X., 2005 Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport., Yang Z., Guo J., Li N., Qian M., Wang S, Zhu X., 2003

Areas of Focus

非整倍肿瘤细胞分裂及其免疫和代谢调控
肿瘤化疗耐药机理，联合靶向治疗和免疫治疗新策略
细胞分裂调控与恶性肿瘤发生、发展的关系

Publications

A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells., Cheng A, Xu T, You W, Wang T, Zhang D, Guo H, Zhang H, Pan X, Wang Y, Liu L, Zhang K, Shi J, Yao X, Guo J, Yang Z., 2023
Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression., Jiang Y, Wang T, Sheng D, Han C, Xu T, Zhang P, You W, Fan W, Zhang Z, Jin T, Duan X, Yuan X, Liu X, Zhang K, Ruan K, Shi J, Guo J, Cheng A, Yang Z., 2022
Energy restriction causes metaphase delay and chromosome mis-segregation in cancer cells., Cheng A, Jiang Y, Wang T, Yu F, Ishrat I, Zhang D, Ji X, Chen M, Xiao W, Li Q, Zhang K, Niu G, Shi J, Pan Y, Yang Z, Guo J., 2021
Aurora-A Mediated Phosphorylation of Lactate Dehydrogenase B promotes glycolysis and tumor growth by relieving the substrate inhibition effect., Cheng A, Zhang P, Wang B, Yang D, Duan X, Jiang Y, Xu T, Jiang Y, Shi J, Ding C, Wu G, Sang Z, Wu Q, Wang H, Wu M, Zhang Z, Pan X, Pan Y, Gao P, Zhang H, Zhou C, Guo J, Yang Z., 2019
Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer., Yin T, Zhao ZB, Guo J, Wang T, Yang JB, Wang C, Long J, Ma S, Huang Q, Zhang K, Ma X, Liu C, Liu S, Lian ZX, Yang Z., 2019
Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B Feedback Loop in late G2 phase., Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Van Dyke T, Wang F, Yao X, Guo J, Yang Z., 2017
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway., Ma X, Wang L, Huang, Li Y, Yang D, Li T, Li F, Sun L, Wei H, He K, Yu F, Zhao D, Hu L, Xing S, Liu Z, Li K, Guo J, Yang Z, Pan X, Li A, Shi Y, Wang J, Gao P, Zhang H., 2017
Misfolded Gbeta2 is recruited to cytoplasmic dynein by Nudel for efficient clearance., Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, Zhu X., 2012
Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments., Yang Z., Kenny A., Brito D., Rieder C., 2009
Extra centrosomes and/or chromosomes prolong mitosis in human cells., Yang Z., Loncarek J., Khodjakov A., Rieder C., 2008
Microtubules do not promote mitotic slippage when the Spindle Assembly Checkpoint cannot be satisfied., Brito D., Yang Z., Rieder C., 2008
Kinetochore Dynein is Required for Normal Chromosome Motion and Congression Independent of the Spindle Checkpoint., Yang Z., Tulu S., Wadsworth P., Rieder C., 2007
Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly., Guo J., Yang Z., Song W., Chen Q., Wang F., Zhang Q., Zhu X., 2006
Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death., Yang Z., Guo J., Chen Q., Du J., Ding C., Zhu X., 2005
Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport., Yang Z., Guo J., Li N., Qian M., Wang S, Zhu X., 2003

非整倍性肿瘤细胞分裂免疫调控代谢调控化疗耐药靶向治疗免疫治疗恶性肿瘤细胞周期

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