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En-Guang Bi
Basic Medical Sciences
Southern Medical University
Guangdong
Language: English, Chinese
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Multiple Myeloma Plasmacytoid Dc Il-9 T Cell Tumor Immunology Immunotherapy Th9 Cells Tc9 Cells Differentiation Antitumor Function
Areas of Focus
  • Immunotherapy for Multiple Myeloma
  • Differentiation and Antitumor Function of IL-9 Secreting Th9/Tc9 Cells
Work Experience
  • 2009-2019 - Various research institutions in the USA - Postdoctoral and Research Assistant
  • 2020-present - Southern Medical University - Professor in Biochemistry Department
Academic Background & Achievements
  • 2009 - PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
  • Guided undergraduate students to win 2 national projects and 1 gold award in national competitions
Publications
  • Aspertaichunol A, an Immunomodulatory Polyketide with an Uncommon Scaffold from the Insect-Derived Endophytic Aspergillus taichungensis SMU01, Cheng X, Ma F, Yan Y, Zhao W, Shi J, Xiao W, Bi E, Luo Q, 2022
  • Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9, Liu L, Bi E, Ma X, Xiong W, Qian J, Ye L, Su P, Wang Q, Xiao L, Yang M, Lu Y, Yi Q, 2020
  • Cholesterol induces CD8+ T-cell exhaustion in the tumor microenvironment, Ma X, Bi E, Lu Y, Su P, Huang C, Liu L, Wang Q, Yang M, Kalady M, Qian J, Zhang A, Gupte A, Hamilton, Zheng C, Yi Q, 2019
  • E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs, Bi E, Li R, Bover LC, Li H, Su P, Ma X, Huang C, Wang Q, Liu L, Yang M, Lin Z, Qian J, Fu W, Liu YJ, Yi Q, 2018
  • Cholesterol negatively regulates IL-9-producing CD8+ T cell differentiation and antitumor activity, Ma X, Bi E, Huang C, Lu Y, Xue G, Guo X, Wang A, Yang M, Qian J, Dong C, Yi Q, 2018
  • Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7, Bi E, Ma X, Lu Y, Yang M, Wang Q, Xue G, Qian J, Wang S, Yi Q, 2017
  • IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells, Ding BB, Bi E, Chen H, Yu JJ, Ye BH, 2013
  • An expanding job description for bcl6, Bi E, Ye BH, 2010
  • Novel function of perforin in regulating CD4+ T cell activation by affecting calcium signaling, Bi E, Huang C, Hu Y, Wu X, Deng W, Lin G, Liu Z, Tian L, Sun S, Mao K, Zou J, Zheng Y, Sun B, 2009
  • IL-12p40 is not required for islet allograft rejection, Bi EG, Shi W, Zou J, Hao ZH, Li ZH, Cai D, Zhang HQ, Sun B, 2006
Awards
  • 2022: Selected for the 'Pearl River Talent Plan' as a Young Top Talent
  • 2022: Excellent Instructor at the 8th National Undergraduate Basic Medical Innovation Research and Experimental Design Forum
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