Professor | En-Guang Bi | Asia Growth Partners

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Name	En-Guang Bi
Contact Information	bienguang1980@smu.edu.cn
Language ability	English, Chinese
Province	Guangdong

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Name

En-Guang Bi

Contact Information

bienguang1980@smu.edu.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	Southern Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2009 - PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences Guided undergraduate students to win 2 national projects and 1 gold award in national competitions
Work Experience	2009-2019 - Various research institutions in the USA - Postdoctoral and Research Assistant 2020-present - Southern Medical University - Professor in Biochemistry Department
Awards	2022: Selected for the 'Pearl River Talent Plan' as a Young Top Talent 2022: Excellent Instructor at the 8th National Undergraduate Basic Medical Innovation Research and Experimental Design Forum

University/Lab Affiliation and Title

Southern Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2009 - PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Guided undergraduate students to win 2 national projects and 1 gold award in national competitions

Work Experience

2009-2019 - Various research institutions in the USA - Postdoctoral and Research Assistant
2020-present - Southern Medical University - Professor in Biochemistry Department

Awards

2022: Selected for the 'Pearl River Talent Plan' as a Young Top Talent
2022: Excellent Instructor at the 8th National Undergraduate Basic Medical Innovation Research and Experimental Design Forum

Areas of Focus	Immunotherapy for Multiple Myeloma Differentiation and Antitumor Function of IL-9 Secreting Th9/Tc9 Cells
Publications	Aspertaichunol A, an Immunomodulatory Polyketide with an Uncommon Scaffold from the Insect-Derived Endophytic Aspergillus taichungensis SMU01, Cheng X, Ma F, Yan Y, Zhao W, Shi J, Xiao W, Bi E, Luo Q, 2022 Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9, Liu L, Bi E, Ma X, Xiong W, Qian J, Ye L, Su P, Wang Q, Xiao L, Yang M, Lu Y, Yi Q, 2020 Cholesterol induces CD8+ T-cell exhaustion in the tumor microenvironment, Ma X, Bi E, Lu Y, Su P, Huang C, Liu L, Wang Q, Yang M, Kalady M, Qian J, Zhang A, Gupte A, Hamilton, Zheng C, Yi Q, 2019 E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs, Bi E, Li R, Bover LC, Li H, Su P, Ma X, Huang C, Wang Q, Liu L, Yang M, Lin Z, Qian J, Fu W, Liu YJ, Yi Q, 2018 Cholesterol negatively regulates IL-9-producing CD8+ T cell differentiation and antitumor activity, Ma X, Bi E, Huang C, Lu Y, Xue G, Guo X, Wang A, Yang M, Qian J, Dong C, Yi Q, 2018 Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7, Bi E, Ma X, Lu Y, Yang M, Wang Q, Xue G, Qian J, Wang S, Yi Q, 2017 IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells, Ding BB, Bi E, Chen H, Yu JJ, Ye BH, 2013 An expanding job description for bcl6, Bi E, Ye BH, 2010 Novel function of perforin in regulating CD4+ T cell activation by affecting calcium signaling, Bi E, Huang C, Hu Y, Wu X, Deng W, Lin G, Liu Z, Tian L, Sun S, Mao K, Zou J, Zheng Y, Sun B, 2009 IL-12p40 is not required for islet allograft rejection, Bi EG, Shi W, Zou J, Hao ZH, Li ZH, Cai D, Zhang HQ, Sun B, 2006

Areas of Focus

Immunotherapy for Multiple Myeloma
Differentiation and Antitumor Function of IL-9 Secreting Th9/Tc9 Cells

Publications

Aspertaichunol A, an Immunomodulatory Polyketide with an Uncommon Scaffold from the Insect-Derived Endophytic Aspergillus taichungensis SMU01, Cheng X, Ma F, Yan Y, Zhao W, Shi J, Xiao W, Bi E, Luo Q, 2022
Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9, Liu L, Bi E, Ma X, Xiong W, Qian J, Ye L, Su P, Wang Q, Xiao L, Yang M, Lu Y, Yi Q, 2020
Cholesterol induces CD8+ T-cell exhaustion in the tumor microenvironment, Ma X, Bi E, Lu Y, Su P, Huang C, Liu L, Wang Q, Yang M, Kalady M, Qian J, Zhang A, Gupte A, Hamilton, Zheng C, Yi Q, 2019
E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs, Bi E, Li R, Bover LC, Li H, Su P, Ma X, Huang C, Wang Q, Liu L, Yang M, Lin Z, Qian J, Fu W, Liu YJ, Yi Q, 2018
Cholesterol negatively regulates IL-9-producing CD8+ T cell differentiation and antitumor activity, Ma X, Bi E, Huang C, Lu Y, Xue G, Guo X, Wang A, Yang M, Qian J, Dong C, Yi Q, 2018
Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7, Bi E, Ma X, Lu Y, Yang M, Wang Q, Xue G, Qian J, Wang S, Yi Q, 2017
IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells, Ding BB, Bi E, Chen H, Yu JJ, Ye BH, 2013
An expanding job description for bcl6, Bi E, Ye BH, 2010
Novel function of perforin in regulating CD4+ T cell activation by affecting calcium signaling, Bi E, Huang C, Hu Y, Wu X, Deng W, Lin G, Liu Z, Tian L, Sun S, Mao K, Zou J, Zheng Y, Sun B, 2009
IL-12p40 is not required for islet allograft rejection, Bi EG, Shi W, Zou J, Hao ZH, Li ZH, Cai D, Zhang HQ, Sun B, 2006

Multiple Myeloma Plasmacytoid Dc Il-9 T Cell Tumor Immunology Immunotherapy Th9 Cells Tc9 Cells Differentiation Antitumor Function

Zhi-Jian Cai - Zhejiang University

Qingqing Wang - Zhejiang University

Hui Yang - Fudan University

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