Professor | 毕恩广 | 数字化转型顾问

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Name	毕恩广
Contact Information	bienguang1980@smu.edu.cn
Language ability	英语, 中文
Province	广东

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Name

毕恩广

Contact Information

bienguang1980@smu.edu.cn

Language ability

英语, 中文

Province

广东

University/Lab Affiliation and Title	南方医科大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	2009年 - 博士学位: 中国科学院上海生化细胞所指导本科生获得2项国家级项目和1项全国比赛金奖
Work Experience	2009-2019年 - 美国多家科研机构 - 博士后和研究助理 2020年至今 - 南方医科大学 - 生化教研室教授
Awards	2022年: 入选“珠江人才计划”青年拔尖人才 2022年: 第八届全国大学生基础医学创新研究暨实验设计论坛优秀指导教师

University/Lab Affiliation and Title

南方医科大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

2009年 - 博士学位: 中国科学院上海生化细胞所
指导本科生获得2项国家级项目和1项全国比赛金奖

Work Experience

2009-2019年 - 美国多家科研机构 - 博士后和研究助理
2020年至今 - 南方医科大学 - 生化教研室教授

Awards

2022年: 入选“珠江人才计划”青年拔尖人才
2022年: 第八届全国大学生基础医学创新研究暨实验设计论坛优秀指导教师

Areas of Focus	多发性骨髓瘤的免疫治疗 IL-9分泌性的Th9/Tc9细胞的分化及其抗肿瘤功能
Publications	Aspertaichunol A, an Immunomodulatory Polyketide with an Uncommon Scaffold from the Insect-Derived Endophytic Aspergillus taichungensis SMU01, Cheng X, Ma F, Yan Y, Zhao W, Shi J, Xiao W, Bi E, Luo Q, 2022 Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9, Liu L, Bi E, Ma X, Xiong W, Qian J, Ye L, Su P, Wang Q, Xiao L, Yang M, Lu Y, Yi Q, 2020 Cholesterol induces CD8+ T-cell exhaustion in the tumor microenvironment, Ma X, Bi E, Lu Y, Su P, Huang C, Liu L, Wang Q, Yang M, Kalady M, Qian J, Zhang A, Gupte A, Hamilton, Zheng C, Yi Q, 2019 E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs, Bi E, Li R, Bover LC, Li H, Su P, Ma X, Huang C, Wang Q, Liu L, Yang M, Lin Z, Qian J, Fu W, Liu YJ, Yi Q, 2018 Cholesterol negatively regulates IL-9-producing CD8+ T cell differentiation and antitumor activity, Ma X, Bi E, Huang C, Lu Y, Xue G, Guo X, Wang A, Yang M, Qian J, Dong C, Yi Q, 2018 Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7, Bi E, Ma X, Lu Y, Yang M, Wang Q, Xue G, Qian J, Wang S, Yi Q, 2017 IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells, Ding BB, Bi E, Chen H, Yu JJ, Ye BH, 2013 An expanding job description for bcl6, Bi E, Ye BH, 2010 Novel function of perforin in regulating CD4+ T cell activation by affecting calcium signaling, Bi E, Huang C, Hu Y, Wu X, Deng W, Lin G, Liu Z, Tian L, Sun S, Mao K, Zou J, Zheng Y, Sun B, 2009 IL-12p40 is not required for islet allograft rejection, Bi EG, Shi W, Zou J, Hao ZH, Li ZH, Cai D, Zhang HQ, Sun B, 2006

Areas of Focus

多发性骨髓瘤的免疫治疗
IL-9分泌性的Th9/Tc9细胞的分化及其抗肿瘤功能

Publications

Aspertaichunol A, an Immunomodulatory Polyketide with an Uncommon Scaffold from the Insect-Derived Endophytic Aspergillus taichungensis SMU01, Cheng X, Ma F, Yan Y, Zhao W, Shi J, Xiao W, Bi E, Luo Q, 2022
Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9, Liu L, Bi E, Ma X, Xiong W, Qian J, Ye L, Su P, Wang Q, Xiao L, Yang M, Lu Y, Yi Q, 2020
Cholesterol induces CD8+ T-cell exhaustion in the tumor microenvironment, Ma X, Bi E, Lu Y, Su P, Huang C, Liu L, Wang Q, Yang M, Kalady M, Qian J, Zhang A, Gupte A, Hamilton, Zheng C, Yi Q, 2019
E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs, Bi E, Li R, Bover LC, Li H, Su P, Ma X, Huang C, Wang Q, Liu L, Yang M, Lin Z, Qian J, Fu W, Liu YJ, Yi Q, 2018
Cholesterol negatively regulates IL-9-producing CD8+ T cell differentiation and antitumor activity, Ma X, Bi E, Huang C, Lu Y, Xue G, Guo X, Wang A, Yang M, Qian J, Dong C, Yi Q, 2018
Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7, Bi E, Ma X, Lu Y, Yang M, Wang Q, Xue G, Qian J, Wang S, Yi Q, 2017
IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells, Ding BB, Bi E, Chen H, Yu JJ, Ye BH, 2013
An expanding job description for bcl6, Bi E, Ye BH, 2010
Novel function of perforin in regulating CD4+ T cell activation by affecting calcium signaling, Bi E, Huang C, Hu Y, Wu X, Deng W, Lin G, Liu Z, Tian L, Sun S, Mao K, Zou J, Zheng Y, Sun B, 2009
IL-12p40 is not required for islet allograft rejection, Bi EG, Shi W, Zou J, Hao ZH, Li ZH, Cai D, Zhang HQ, Sun B, 2006

多发性骨髓瘤浆样树突状细胞 Il-9 T细胞肿瘤免疫免疫治疗 Th9细胞 Tc9细胞分化抗肿瘤功能

李扬 - 北京大学

蔡志坚 - 浙江大学

Area of Focus
肿瘤 | 免疫 | 逃逸 | 机制 | 免疫调节 | 自身免疫 | 疾病 | Cd4+ | T细胞 | 分化

潘荣清 - 浙江大学

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