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Daogang Guan
Basic Medical Sciences
Southern Medical University
Guangdong
Language: Chinese, English
Multi-Omics Data Modeling
Translational Medicine
Molecular Mechanisms
Complex Diseases
Gene Regulatory Networks
Non-Coding Rna
Systems Biology
Computer-Aided Drug Design
Mathematical Modeling
Embryonic Development
Areas of Focus
- High-throughput data integration modeling to analyze molecular mechanisms of complex diseases
- Mathematical modeling and quantification of complex gene regulatory networks in disease occurrence, cell fate determination, and embryonic development
- Non-coding RNA detection and functional mining
- Systems biology, translational medicine, and computer-aided drug design
Work Experience
- 2011.7-2012.7 - Sun Yat-sen University, School of Life Sciences - Project Employment
- 2012.8-2014.8 - Hong Kong Baptist University, Department of Biology - Senior Research Assistant
- 2014.9-2016.8 - Hong Kong Baptist University, Department of Biology - Research Assistant Professor
- 2016.9-2019.8 - Hong Kong Baptist University, Institute of Integrated Bioinformatics and Translational Science - Assistant Professor
Academic Background & Achievements
- 2005.9-2011.7 Doctorate: Sun Yat-sen University, School of Life Sciences
Publications
- PlaMoM: a comprehensive database compiles plant mobile macromolecule, Guan D, Yan B, Thieme C, Hua J, Zhu H, Boheler KR, Zhao Z, Kragler F, Xia Y, Zhang S, 2017
- Analyzing and Predicting Phloem Mobility of Macromolecules with an Online Database, Guan D, Xia Y, Zhang S, 2019
- PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data, Guan D, Shao J, Zhao Z, Wang P, Qin J, Deng Y, Boheler KR, Wang J, Yan B, 2014
- CMGRN: a web server for constructing multilevel gene regulatory networks using ChIP-seq and gene expression data, Guan D, Shao J, Deng Y, Wang P, Zhao Z, Liang Y, Wang J, Yan B, 2014
- mirExplorer: detecting microRNAs from genome and next generation sequencing data using the AdaBoost method with transition probability matrix and combined features, Guan DG, Liao JY, Qu ZH, Zhang Y, Qu, 2011
- An integrative method to decode regulatory logics in gene transcription, Yan B, Guan D, Wang C, Wang J, He B, Qin J, KR Boheler, Lu A, Zhang G, Zhu H, 2017
- A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA-mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice, Zhuo Z, Wan Y, Guan D, Ni S, Wang L, Zhang Z, Liu J, Liang C, Yu Y, Lu A, Zhang G, Zhang B, 2020
- A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration, Zhang Z, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B, 2018
- Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy Following Mechanical Unloading, Zhang Z, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B, 2018
- Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age2 related osteoporosis, Liang C, Peng S, Li J, Lu J, Guan D, Jiang F, Lu Cheng, Li F, He X, Zhu H, Au D, Yang D, Zhang B, Lu A, Zhang G, 2018
- Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry, Ho VW, Wong MK, An X, Guan D, Shao J, Ng HC, Ren X, He K, Liao J, Ang Y, Chen L, Huang X, Yan B, Xia Y, Chan LL, Chow KL, Yan H, Zhao Z, 2015
- System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia, Wang C, Ren Q, Chen X, Song Z, Ning Z, Gan J, Ma X, Liang D, Guan D, Liu Z, Lu A, 2018
- Systems-Mapping of Herbal Effects on Complex Diseases Using the Network-Perturbation Signatures, Chen X, Zheng C, Wang C, Guo Z, Gao S, Ning Z, Huang C, Lu C, Fu Y, Guan D, Lu A, Wang Y, 2018
- Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets, He K, Li WX, Guan D, Gong M, Ye S, Fang Z, Huang JF, Lu A, 2019
- Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial, Zhang C, Guan D, Jiang M, Liang C, Li L, Zhao N, Zha Q, Zhang W, Lu C, Zhang G, Liu J, Lu A, 2019
- A transcriptomic study of myogenic differentiation under the overexpression of PPARγ by RNA-Seq, Kan He, Guoying Wu, Wen-Xing Li, Daogang Guan, Wenwen Lv, Mengting Gong, Shoudong Ye, Aiping Lu, 2017
- Bushenyijing fang reduces fall risk in late postmenopausal women with osteopenia: a randomized double-blind and placebo-controlled trial, Zheng Y, Wang X, Zhang Z, Guo B, Dang L, He B, Zhang C, Zhou J, Shi W, Zhao Y, Zhan H, Xu Y, Liang C, Liu J, Guan D, Wang L, Wu X, Li J, Zhuo Z, Lin Z, Qiu H, Zhong L, Bian Z, Shi Y, Zhang B, Zhang G, Lu A, 2019
- ncRNAimprint: a comprehensive database of mammalian imprinted noncoding RNAs, Zhang Y, Guan DG, Yang JH, Shao P, Zhou H, Qu LH, 2010
- Network Intervention, a Method to Address Complex Therapeutic Strategies, Zhang C, Zhou W, Guan DG, Wang YH, Lu AP, 2018
- Integrated transcriptomics and regulatory network analyses identify microRNA-200c as a novel repressor of differentiation and maturation of human pluripotent stem cell-derived cardiomyocytes, ENY Poon, B Hao, D Guan, MJ Li, J Lu, Y Yang, B Wu, SE Webb, SCM Wu, ALMiller, Y Liang, X Yao, J Wang, B Yan, KR Boheler, 2018
- Drastic expression change of transposon-derived piRNA-like RNAs and microRNAs in early stages of chicken embryos implies a role in gastrulation, Shao P, Liao JY, Guan DG, Yang JH, Zheng LL, Jing Q, Zhou H, Qu LH, 2012
- A water-soluble nucleolin aptamer-paclitaxel conjugate fortumor-specific targeting in 1 ovarian cancer, Li F, Lu J, Liu J, Liang C, Wang M, Wang L, Li D, Yao H, Zhang Q, Wen J, Zhang Z, Li J, Lu Q, He X, Guo B, Guan D, Yu Y, Dang L, Wu X, Li Y, Chen G, Jiang F, Sun S, Zhang B, Lu A, Zhang G, 2017
- PARP1 in carcinomas and PARP1 inhibitors as antineoplastic drugs, Wang L, Liang C, Li F, Guan D, Wu X, Fu X, Lu A, Zhang G, 2017
- Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer, Lv Q, Meng Z, Yu Y, Jiang F, Guan D, Liang C, Zhou J, Lu A, Zhang G, 2016
- Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research, Lv H, Jiang F, Guan D, Lu C, Guo B, Chan C, Peng S, Liu B, Guo W, Zhu H, Xu X, Lu A, Zhang G, 2016
- Timing of Tissue-specific Cell Division Requires a Differential Onset of Zygotic Transcription during Metazoan Embryogenesis, Wong MK, Guan D, Ng HC, Ho VW, An X, Li R, Ren X, Zhao Z, 2016
- Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer, Zhang J, Yan B, Spath SS, Qun H, Cornelius S, Guan D, Shao J, Hagiwara K, Van Waes C, Chen Z, Su X, Bi Y, 2015
- Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor, Wang J, Yan B, Liu SM, Sun H, Pan Y, Guan D, Zhang X, Xu J, Ma H, 2015
- A contig-based strategy for the genome-wide discovery of microRNAs without complete genome resources, Wen JZ, Liao JY, Zheng LL, Xu H, Yang JH, Guan DG, Zhang SM, Zhou H, Qu LH, 2014
- Unraveling regulatory programs for NF-kappaB, p53 and microRNAs in head and neck squamous cell carcinoma, Yan B, Li H, Yang X, Shao J, Jang M, Guan D, Zou S, Van Waes C, Chen Z, Zhan M, 2013
- Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs, Shao P, Yang JH, Zhou H, Guan DG, Qu LH, 2009
- SnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights, Liu N, Xiao ZD, Yu CH, Shao P, Liang YT, Guan DG, Yang JH, Chen CL, Qu LH, Zhou H, 2009
