2005.9-2011.7 Doctorate: Sun Yat-sen University, School of Life Sciences
2011.7-2012.7 - Sun Yat-sen University, School of Life Sciences - Project Employment
2012.8-2014.8 - Hong Kong Baptist University, Department of Biology - Senior Research Assistant
2014.9-2016.8 - Hong Kong Baptist University, Department of Biology - Research Assistant Professor
2016.9-2019.8 - Hong Kong Baptist University, Institute of Integrated Bioinformatics and Translational Science - Assistant Professor
Research
High-throughput data integration modeling to analyze molecular mechanisms of complex diseases Mathematical modeling and quantification of complex gene regulatory networks in disease occurrence, cell fate determination, and embryonic development Non-coding RNA detection and functional mining Systems biology, translational medicine, and computer-aided drug design
PlaMoM: a comprehensive database compiles plant mobile macromolecule, Guan D, Yan B, Thieme C, Hua J, Zhu H, Boheler KR, Zhao Z, Kragler F, Xia Y, Zhang S, 2017
Analyzing and Predicting Phloem Mobility of Macromolecules with an Online Database, Guan D, Xia Y, Zhang S, 2019
PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data, Guan D, Shao J, Zhao Z, Wang P, Qin J, Deng Y, Boheler KR, Wang J, Yan B, 2014
CMGRN: a web server for constructing multilevel gene regulatory networks using ChIP-seq and gene expression data, Guan D, Shao J, Deng Y, Wang P, Zhao Z, Liang Y, Wang J, Yan B, 2014
mirExplorer: detecting microRNAs from genome and next generation sequencing data using the AdaBoost method with transition probability matrix and combined features, Guan DG, Liao JY, Qu ZH, Zhang Y, Qu, 2011
An integrative method to decode regulatory logics in gene transcription, Yan B, Guan D, Wang C, Wang J, He B, Qin J, KR Boheler, Lu A, Zhang G, Zhu H, 2017
A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA-mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice, Zhuo Z, Wan Y, Guan D, Ni S, Wang L, Zhang Z, Liu J, Liang C, Yu Y, Lu A, Zhang G, Zhang B, 2020
A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration, Zhang Z, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B, 2018
Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy Following Mechanical Unloading, Zhang Z, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B, 2018
Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age2 related osteoporosis, Liang C, Peng S, Li J, Lu J, Guan D, Jiang F, Lu Cheng, Li F, He X, Zhu H, Au D, Yang D, Zhang B, Lu A, Zhang G, 2018
Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry, Ho VW, Wong MK, An X, Guan D, Shao J, Ng HC, Ren X, He K, Liao J, Ang Y, Chen L, Huang X, Yan B, Xia Y, Chan LL, Chow KL, Yan H, Zhao Z, 2015
System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia, Wang C, Ren Q, Chen X, Song Z, Ning Z, Gan J, Ma X, Liang D, Guan D, Liu Z, Lu A, 2018
Systems-Mapping of Herbal Effects on Complex Diseases Using the Network-Perturbation Signatures, Chen X, Zheng C, Wang C, Guo Z, Gao S, Ning Z, Huang C, Lu C, Fu Y, Guan D, Lu A, Wang Y, 2018
Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets, He K, Li WX, Guan D, Gong M, Ye S, Fang Z, Huang JF, Lu A, 2019
Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial, Zhang C, Guan D, Jiang M, Liang C, Li L, Zhao N, Zha Q, Zhang W, Lu C, Zhang G, Liu J, Lu A, 2019
A transcriptomic study of myogenic differentiation under the overexpression of PPARγ by RNA-Seq, Kan He, Guoying Wu, Wen-Xing Li, Daogang Guan, Wenwen Lv, Mengting Gong, Shoudong Ye, Aiping Lu, 2017
Bushenyijing fang reduces fall risk in late postmenopausal women with osteopenia: a randomized double-blind and placebo-controlled trial, Zheng Y, Wang X, Zhang Z, Guo B, Dang L, He B, Zhang C, Zhou J, Shi W, Zhao Y, Zhan H, Xu Y, Liang C, Liu J, Guan D, Wang L, Wu X, Li J, Zhuo Z, Lin Z, Qiu H, Zhong L, Bian Z, Shi Y, Zhang B, Zhang G, Lu A, 2019
ncRNAimprint: a comprehensive database of mammalian imprinted noncoding RNAs, Zhang Y, Guan DG, Yang JH, Shao P, Zhou H, Qu LH, 2010
Network Intervention, a Method to Address Complex Therapeutic Strategies, Zhang C, Zhou W, Guan DG, Wang YH, Lu AP, 2018
Integrated transcriptomics and regulatory network analyses identify microRNA-200c as a novel repressor of differentiation and maturation of human pluripotent stem cell-derived cardiomyocytes, ENY Poon, B Hao, D Guan, MJ Li, J Lu, Y Yang, B Wu, SE Webb, SCM Wu, ALMiller, Y Liang, X Yao, J Wang, B Yan, KR Boheler, 2018
Drastic expression change of transposon-derived piRNA-like RNAs and microRNAs in early stages of chicken embryos implies a role in gastrulation, Shao P, Liao JY, Guan DG, Yang JH, Zheng LL, Jing Q, Zhou H, Qu LH, 2012
A water-soluble nucleolin aptamer-paclitaxel conjugate fortumor-specific targeting in 1 ovarian cancer, Li F, Lu J, Liu J, Liang C, Wang M, Wang L, Li D, Yao H, Zhang Q, Wen J, Zhang Z, Li J, Lu Q, He X, Guo B, Guan D, Yu Y, Dang L, Wu X, Li Y, Chen G, Jiang F, Sun S, Zhang B, Lu A, Zhang G, 2017
PARP1 in carcinomas and PARP1 inhibitors as antineoplastic drugs, Wang L, Liang C, Li F, Guan D, Wu X, Fu X, Lu A, Zhang G, 2017
Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer, Lv Q, Meng Z, Yu Y, Jiang F, Guan D, Liang C, Zhou J, Lu A, Zhang G, 2016
Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research, Lv H, Jiang F, Guan D, Lu C, Guo B, Chan C, Peng S, Liu B, Guo W, Zhu H, Xu X, Lu A, Zhang G, 2016
Timing of Tissue-specific Cell Division Requires a Differential Onset of Zygotic Transcription during Metazoan Embryogenesis, Wong MK, Guan D, Ng HC, Ho VW, An X, Li R, Ren X, Zhao Z, 2016
Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer, Zhang J, Yan B, Spath SS, Qun H, Cornelius S, Guan D, Shao J, Hagiwara K, Van Waes C, Chen Z, Su X, Bi Y, 2015
Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor, Wang J, Yan B, Liu SM, Sun H, Pan Y, Guan D, Zhang X, Xu J, Ma H, 2015
A contig-based strategy for the genome-wide discovery of microRNAs without complete genome resources, Wen JZ, Liao JY, Zheng LL, Xu H, Yang JH, Guan DG, Zhang SM, Zhou H, Qu LH, 2014
Unraveling regulatory programs for NF-kappaB, p53 and microRNAs in head and neck squamous cell carcinoma, Yan B, Li H, Yang X, Shao J, Jang M, Guan D, Zou S, Van Waes C, Chen Z, Zhan M, 2013
Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs, Shao P, Yang JH, Zhou H, Guan DG, Qu LH, 2009
SnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights, Liu N, Xiao ZD, Yu CH, Shao P, Liang YT, Guan DG, Yang JH, Chen CL, Qu LH, Zhou H, 2009
Keywords
Multi-Omics Data ModelingTranslational MedicineMolecular MechanismsComplex DiseasesGene Regulatory NetworksNon-Coding RnaSystems BiologyComputer-Aided Drug DesignMathematical ModelingEmbryonic Development
