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官道刚
guandg0929@hotmail.com
中文, 英语
广东
南方医科大学
Basic Medical Sciences
  • 2005.9-2011.7 博士:中山大学,生命科学学院
  • 2011.7-2012.7 - 中山大学,生命科学学院 - 项目聘用
  • 2012.8-2014.8 - 香港浸会大学,理学院生物系 - 高级研究助理
  • 2014.9-2016.8 - 香港浸会大学,理学院生物系 - 研究助理教授
  • 2016.9-2019.8 - 香港浸会大学,整合生物信息医学与转化科学研究所 - 助理教授
高通量数据整合建模解析复杂疾病的分子机制
疾病发生、细胞命运决定、胚胎发育过程中复杂基因调控网络的数学建模及量化
非编码RNA探测及功能挖掘
系统生物学、转化医学和计算机辅助药物设计
  • PlaMoM: a comprehensive database compiles plant mobile macromolecule, Guan D, Yan B, Thieme C, Hua J, Zhu H, Boheler KR, Zhao Z, Kragler F, Xia Y, Zhang S, 2017
  • Analyzing and Predicting Phloem Mobility of Macromolecules with an Online Database, Guan D, Xia Y, Zhang S, 2019
  • PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data, Guan D, Shao J, Zhao Z, Wang P, Qin J, Deng Y, Boheler KR, Wang J, Yan B, 2014
  • CMGRN: a web server for constructing multilevel gene regulatory networks using ChIP-seq and gene expression data, Guan D, Shao J, Deng Y, Wang P, Zhao Z, Liang Y, Wang J, Yan B, 2014
  • mirExplorer: detecting microRNAs from genome and next generation sequencing data using the AdaBoost method with transition probability matrix and combined features, Guan DG, Liao JY, Qu ZH, Zhang Y, Qu, 2011
  • An integrative method to decode regulatory logics in gene transcription, Yan B, Guan D, Wang C, Wang J, He B, Qin J, KR Boheler, Lu A, Zhang G, Zhu H, 2017
  • A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA-mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice, Zhuo Z, Wan Y, Guan D, Ni S, Wang L, Zhang Z, Liu J, Liang C, Yu Y, Lu A, Zhang G, Zhang B, 2020
  • A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration, Zhang Z, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B, 2018
  • Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy Following Mechanical Unloading, Zhang Z, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang B, 2018
  • Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age2 related osteoporosis, Liang C, Peng S, Li J, Lu J, Guan D, Jiang F, Lu Cheng, Li F, He X, Zhu H, Au D, Yang D, Zhang B, Lu A, Zhang G, 2018
  • Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry, Ho VW, Wong MK, An X, Guan D, Shao J, Ng HC, Ren X, He K, Liao J, Ang Y, Chen L, Huang X, Yan B, Xia Y, Chan LL, Chow KL, Yan H, Zhao Z, 2015
  • System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia, Wang C, Ren Q, Chen X, Song Z, Ning Z, Gan J, Ma X, Liang D, Guan D, Liu Z, Lu A, 2018
  • Systems-Mapping of Herbal Effects on Complex Diseases Using the Network-Perturbation Signatures, Chen X, Zheng C, Wang C, Guo Z, Gao S, Ning Z, Huang C, Lu C, Fu Y, Guan D, Lu A, Wang Y, 2018
  • Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets, He K, Li WX, Guan D, Gong M, Ye S, Fang Z, Huang JF, Lu A, 2019
  • Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial, Zhang C, Guan D, Jiang M, Liang C, Li L, Zhao N, Zha Q, Zhang W, Lu C, Zhang G, Liu J, Lu A, 2019
  • A transcriptomic study of myogenic differentiation under the overexpression of PPARγ by RNA-Seq, Kan He, Guoying Wu, Wen-Xing Li, Daogang Guan, Wenwen Lv, Mengting Gong, Shoudong Ye, Aiping Lu, 2017
  • Bushenyijing fang reduces fall risk in late postmenopausal women with osteopenia: a randomized double-blind and placebo-controlled trial, Zheng Y, Wang X, Zhang Z, Guo B, Dang L, He B, Zhang C, Zhou J, Shi W, Zhao Y, Zhan H, Xu Y, Liang C, Liu J, Guan D, Wang L, Wu X, Li J, Zhuo Z, Lin Z, Qiu H, Zhong L, Bian Z, Shi Y, Zhang B, Zhang G, Lu A, 2019
  • ncRNAimprint: a comprehensive database of mammalian imprinted noncoding RNAs, Zhang Y, Guan DG, Yang JH, Shao P, Zhou H, Qu LH, 2010
  • Network Intervention, a Method to Address Complex Therapeutic Strategies, Zhang C, Zhou W, Guan DG, Wang YH, Lu AP, 2018
  • Integrated transcriptomics and regulatory network analyses identify microRNA-200c as a novel repressor of differentiation and maturation of human pluripotent stem cell-derived cardiomyocytes, ENY Poon, B Hao, D Guan, MJ Li, J Lu, Y Yang, B Wu, SE Webb, SCM Wu, ALMiller, Y Liang, X Yao, J Wang, B Yan, KR Boheler, 2018
  • Drastic expression change of transposon-derived piRNA-like RNAs and microRNAs in early stages of chicken embryos implies a role in gastrulation, Shao P, Liao JY, Guan DG, Yang JH, Zheng LL, Jing Q, Zhou H, Qu LH, 2012
  • A water-soluble nucleolin aptamer-paclitaxel conjugate fortumor-specific targeting in 1 ovarian cancer, Li F, Lu J, Liu J, Liang C, Wang M, Wang L, Li D, Yao H, Zhang Q, Wen J, Zhang Z, Li J, Lu Q, He X, Guo B, Guan D, Yu Y, Dang L, Wu X, Li Y, Chen G, Jiang F, Sun S, Zhang B, Lu A, Zhang G, 2017
  • PARP1 in carcinomas and PARP1 inhibitors as antineoplastic drugs, Wang L, Liang C, Li F, Guan D, Wu X, Fu X, Lu A, Zhang G, 2017
  • Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer, Lv Q, Meng Z, Yu Y, Jiang F, Guan D, Liang C, Zhou J, Lu A, Zhang G, 2016
  • Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research, Lv H, Jiang F, Guan D, Lu C, Guo B, Chan C, Peng S, Liu B, Guo W, Zhu H, Xu X, Lu A, Zhang G, 2016
  • Timing of Tissue-specific Cell Division Requires a Differential Onset of Zygotic Transcription during Metazoan Embryogenesis, Wong MK, Guan D, Ng HC, Ho VW, An X, Li R, Ren X, Zhao Z, 2016
  • Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer, Zhang J, Yan B, Spath SS, Qun H, Cornelius S, Guan D, Shao J, Hagiwara K, Van Waes C, Chen Z, Su X, Bi Y, 2015
  • Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor, Wang J, Yan B, Liu SM, Sun H, Pan Y, Guan D, Zhang X, Xu J, Ma H, 2015
  • A contig-based strategy for the genome-wide discovery of microRNAs without complete genome resources, Wen JZ, Liao JY, Zheng LL, Xu H, Yang JH, Guan DG, Zhang SM, Zhou H, Qu LH, 2014
  • Unraveling regulatory programs for NF-kappaB, p53 and microRNAs in head and neck squamous cell carcinoma, Yan B, Li H, Yang X, Shao J, Jang M, Guan D, Zou S, Van Waes C, Chen Z, Zhan M, 2013
  • Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs, Shao P, Yang JH, Zhou H, Guan DG, Qu LH, 2009
  • SnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights, Liu N, Xiao ZD, Yu CH, Shao P, Liang YT, Guan DG, Yang JH, Chen CL, Qu LH, Zhou H, 2009
多组学数据建模 转化医学 分子机制 复杂疾病 基因调控网络 非编码Rna 系统生物学 计算机辅助药物设计 数学建模 胚胎发育

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