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Yang Wei
Basic Medical Sciences
Southern Medical University
Guangdong
Language: Chinese, English
Immunometabolism
T Cell
Tumor Immunotherapy
Cancer Immunology
Lipid Metabolism
Cholesterol Metabolism
Cd8+ T Cells
Macrophage Activation
Pd-1 Ubiquitination
Ldlr-Mediated Tcr Recycling
Areas of Focus
- Immunometabolism and Tumor Immunity
Work Experience
- 2013-2016 - Postdoctoral Research: Chinese Academy of Sciences
- 2016-present - Professor, Doctoral Supervisor: Southern Medical University
Academic Background & Achievements
- 2013 - PhD in Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- 2018 - National Natural Science Foundation Excellent Young Scientist Fund recipient
- 2017 - Guangdong Province Young Scholar
- 2017 - Guangdong Province High-level Talent Science Fund recipient
Publications
- Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism, Yang W*, Bai Y*, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu CG, Yan C, Wang L, Chang CCY, Chang TY, Zhang T, Zhou P, Song BL, Liu W, Sun SC, Liu X, Li BL#, Xu C#, 2016
- Ca2+ regulates T cell receptor activation by modulating the electrostatic property of phospholipids, Shi X*, Bi Y*, Yang W*, Guo X, Jiang Y, Wan C, Li L, Bai Y, Guo J, Wang Y, Chen X, Wu B, Sun H, Liu W, Wang J, Xu C, 2013
- Dynamic regulation of CD28 conformation and signaling by charged lipids and ions, Yang W*, Pan W*, Chen S*, Trendel N*, Jiang S*, Xiao F, Xue M, Wu W, Peng Z, Li X, Ji H, Liu X, Jiang H, Wang H, Shen H, Dushek O#, Li H#, Xu C#, 2017
- Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression, Xiang W*, Shi R*, Kang X*, Zhang X*, Chen P, Zhang L, Hou A, Wang R, Zhao Y, Zhao K, Liu Y, Ma Y, Luo H, Shang S, Zhang J, He F, Yu S, Gan L, Shi C, Li Y#, Yang W#, Liang H#, Miao H#, 2018
- FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells, Meng X, Liu X, Guo X, Jiang S, Chen T, Hu Z, Liu H, Bai Y, Xue M, Hu R, Sun SC, Liu XL, Zhou P, Huang X, Wei L, Yang W& Xu C, 2018
- Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promotes LDLR-mediated TCR recycling and signaling, Not mentioned, 2021
Awards
- 2017: Guangdong Province Young Scholar
