Professor | Jiayu Chen | Asia Growth Partners

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Name	Jiayu Chen
Contact Information	jiayuchen@nju.edu.cn
Language ability	Chinese, English
Province	Jiangsu

Upload Avatar (500 x 500)

Name

Jiayu Chen

Contact Information

jiayuchen@nju.edu.cn

Language ability

Chinese, English

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing University
Faculty	Life Sciences
Academic Background & Achievements	2006-2010 Bachelor Degree: School of Life Sciences, Shandong University 2010-2015 Doctor Degree: Institute of Molecular Medicine, Peking University
Work Experience	2016-2021 - UCSD - Postdoctoral Scholar 2021- - Nanjing University - Principal Investigator 2021- - Chemistry and Biomedicine Innovation Center, Nanjing University - Principal Investigator

University/Lab Affiliation and Title

Nanjing University

Faculty

Life Sciences

Academic Background & Achievements

2006-2010 Bachelor Degree: School of Life Sciences, Shandong University
2010-2015 Doctor Degree: Institute of Molecular Medicine, Peking University

Work Experience

2016-2021 - UCSD - Postdoctoral Scholar
2021- - Nanjing University - Principal Investigator
2021- - Chemistry and Biomedicine Innovation Center, Nanjing University - Principal Investigator

Areas of Focus	Non-B DNA Structures Regulatory RNA
Publications	Chemoproteomic Profiling Unveils Binding and Functional Diversity of Endogenous Proteins That Interact with Endogenous Triplex DNA, Xu, H., Ye, J., Zhang, K.X., Hu, Q., Cui, T., Tong, C., Wang, M., Geng, H., Shui, K.M., Sun, Y., Wang, J., Hou, X., Zhang, K., Xie, R., Yin, Y., Chen, N. and Chen, J.Y.#, 2024 Deep Learning-Enhanced R-loop Prediction Provides Mechanistic Implications for Repeat Expansion Diseases, Hu, J., Xing, Z., Yang, H., Zhou, Y., Guo, L., Zhang, X., Xu, L., Liu, Q., Ye, J., Zhong, X., Wang, J., Lin, R., Long, E., Jiang, J., Chen, L., Pan, Y., He, L.# and Chen, J.Y.#, 2024 nASAP: A Nascent RNA Profiling Data Analysis Platform, Wang, Z., Ge, P., Zhou, X.L., Shui, K.M., Geng, H., Yang, J.#, Chen, J.Y.# and Wang, J.#, 2023 Microhomology-Mediated Circular DNA Formation from Oligonucleosomal Fragments During Spermatogenesis, Hu, J., Zhang, Z., Xiao, S., Cao, Y., Chen, Y., Weng, J., Jiang, H.#, Li, W.#, Chen, J.Y.# and Liu, C.#, 2023 R-loopBase: a knowledgebase for genome-wide R-loop formation and regulation, Lin, R., Zhong, X.#, Zhou, Y., Geng, H., Hu, Q., Huang, Z., Hu, J., Fu, X.D., Chen, L.# and Chen, J.Y.#, 2021 Mechanistic Dissection of RNA Binding Proteins in Regulated Gene Expression at Chromatin Levels, Chen, J.Y., Lim, D.H. and Fu, X.D., 2019 Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription, Xiao, R., Chen, J.Y. et al., 2019 R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1, Chen, J.Y. et al., 2019 Evolutionarily significant A-to-I RNA editing events originated through G-to-A mutations in primates, An, N.A., Ding, W. , Yang, X.Z., …, Chen, J.Y.#and Li, C.Y.#, 2019 The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations, Chen, L., Chen, J.Y.* et al., 2018 R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters, Chen, L., Chen, J.Y., Zhang, X., Gu, Y., Xiao, R., Shao, C., …, Fu, X.D. et al., 2017 Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates, Chen, J.Y.* et al., 2015 Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates, Yang, X.Z., Chen, J.Y. et al., 2015 RNA Editome in Rhesus Macaque Shaped by Purifying Selection, Chen, J.Y.* et al., 2014 Hominoid-specific De Novo Protein-coding Genes Originating from Long Non-coding RNAs, Xie, C., Zhang, Y.E., Chen, J.Y.* et al., 2012

Areas of Focus

Non-B DNA Structures
Regulatory RNA

Publications

Chemoproteomic Profiling Unveils Binding and Functional Diversity of Endogenous Proteins That Interact with Endogenous Triplex DNA, Xu, H.*, Ye, J.*, Zhang, K.X.*, Hu, Q., Cui, T., Tong, C., Wang, M., Geng, H., Shui, K.M., Sun, Y., Wang, J., Hou, X., Zhang, K., Xie, R., Yin, Y., Chen, N. and Chen, J.Y.#, 2024
Deep Learning-Enhanced R-loop Prediction Provides Mechanistic Implications for Repeat Expansion Diseases, Hu, J.*, Xing, Z.*, Yang, H.*, Zhou, Y.*, Guo, L., Zhang, X., Xu, L., Liu, Q., Ye, J., Zhong, X., Wang, J., Lin, R., Long, E., Jiang, J., Chen, L., Pan, Y., He, L.# and Chen, J.Y.#, 2024
nASAP: A Nascent RNA Profiling Data Analysis Platform, Wang, Z., Ge, P., Zhou, X.L., Shui, K.M., Geng, H., Yang, J.#, Chen, J.Y.# and Wang, J.#, 2023
Microhomology-Mediated Circular DNA Formation from Oligonucleosomal Fragments During Spermatogenesis, Hu, J.*, Zhang, Z.*, Xiao, S., Cao, Y., Chen, Y., Weng, J., Jiang, H.#, Li, W.#, Chen, J.Y.# and Liu, C.#, 2023
R-loopBase: a knowledgebase for genome-wide R-loop formation and regulation, Lin, R.*, Zhong, X.*#, Zhou, Y.*, Geng, H., Hu, Q., Huang, Z., Hu, J., Fu, X.D., Chen, L.# and Chen, J.Y.#, 2021
Mechanistic Dissection of RNA Binding Proteins in Regulated Gene Expression at Chromatin Levels, Chen, J.Y., Lim, D.H. and Fu, X.D., 2019
Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription, Xiao, R.*, Chen, J.Y.* et al., 2019
R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1, Chen, J.Y. et al., 2019
Evolutionarily significant A-to-I RNA editing events originated through G-to-A mutations in primates, An, N.A.*, Ding, W. *, Yang, X.Z.*, …, Chen, J.Y.#and Li, C.Y.#, 2019
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations, Chen, L.*, Chen, J.Y.* et al., 2018
R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters, Chen, L.*, Chen, J.Y.*, Zhang, X., Gu, Y., Xiao, R., Shao, C., …, Fu, X.D. et al., 2017
Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates, Chen, J.Y.* et al., 2015
Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates, Yang, X.Z.*, Chen, J.Y.* et al., 2015
RNA Editome in Rhesus Macaque Shaped by Purifying Selection, Chen, J.Y.* et al., 2014
Hominoid-specific De Novo Protein-coding Genes Originating from Long Non-coding RNAs, Xie, C.*, Zhang, Y.E.*, Chen, J.Y.* et al., 2012

Genomics Bioinformatics Molecular Biology Chemical Biology Nucleic Acids Drug Targets Biomarkers Therapeutics Rna Dna

Qi Liu - Tongji University

Lu Dongdong - Tongji University

Guifen Liu - Tongji University

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