Professor | Wenjie Guo | Asia Growth Partners

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Name	Wenjie Guo
Contact Information	guowj@nju.edu.cn
Language ability	Chinese, English
Province	Jiangsu

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Name

Wenjie Guo

Contact Information

guowj@nju.edu.cn

Language ability

Chinese, English

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing University
Faculty	Life Sciences
Academic Background & Achievements	2003/09-2007/06 Bachelor in Pharmaceutical Engineering: Jiangsu University 2007/09-2010/06 Master in Pharmacognosy: Jiangsu University 2010/09-2013/06 PhD in Pharmacology: Nanjing University Achievement: First Prize in Natural Science Award by Ministry of Education
Work Experience	2013/08-2015/06 - Jiangsu University - Lecturer 2015/07-2022/01 - Nanjing University - Associate Professor 2020/09-Present - Nanjing University - Doctoral Supervisor 2022/01-Present - Nanjing University - Professor
Awards	2022: Second Prize in Jiangsu Medical Science and Technology Award 2021: Excellent Teaching Team of Jiangsu Higher Education 'Qinglan Project' 2019: Servier Young Pharmacologist Award by Chinese Pharmacological Society 2018: Second Prize in Jiangsu Education and Research Achievement 2018: First Prize in Natural Science Award by Ministry of Education 2015: 19th Young Pharmacologist Award by Chinese Pharmacological Society 2015: Excellent Doctoral Dissertation of Nanjing University 2015: Excellent Doctoral Dissertation of Jiangsu Province

University/Lab Affiliation and Title

Nanjing University

Faculty

Life Sciences

Academic Background & Achievements

2003/09-2007/06 Bachelor in Pharmaceutical Engineering: Jiangsu University
2007/09-2010/06 Master in Pharmacognosy: Jiangsu University
2010/09-2013/06 PhD in Pharmacology: Nanjing University
Achievement: First Prize in Natural Science Award by Ministry of Education

Work Experience

2013/08-2015/06 - Jiangsu University - Lecturer
2015/07-2022/01 - Nanjing University - Associate Professor
2020/09-Present - Nanjing University - Doctoral Supervisor
2022/01-Present - Nanjing University - Professor

Awards

2022: Second Prize in Jiangsu Medical Science and Technology Award
2021: Excellent Teaching Team of Jiangsu Higher Education 'Qinglan Project'
2019: Servier Young Pharmacologist Award by Chinese Pharmacological Society
2018: Second Prize in Jiangsu Education and Research Achievement
2018: First Prize in Natural Science Award by Ministry of Education
2015: 19th Young Pharmacologist Award by Chinese Pharmacological Society
2015: Excellent Doctoral Dissertation of Nanjing University
2015: Excellent Doctoral Dissertation of Jiangsu Province

Areas of Focus	Mechanisms of inflammation resolution and drug regulation
Publications	Allosterically activating SHP2 using oleanolic acid inhibited the STAT3-Th17 axis and ameliorated colitis, Jinbo Hu, Wen Liu, Yi Zou, Chenyang Jiao, Jiazhen Zhu, Jianjun Zou, Yang Sun, Qiang Xu, Wenjie Guo, 2024 IDO1 inhibition promotes activation of tumor-intrinsic STAT3 pathway and induces adverse tumor-protective effects, Longbo Yu, Lingyan Xu, Yunjie Chen, Yicheng Rong, Yi Zou, Shushan Ge, Tiancong Wu, Yisheng Lai, Qiang Xu, Wenjie Guo, Wen Liu, 2024 A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway, Wu Xiaohan, Xu Lingyan, Li Xiaofei, Zhou Yirui, Han Xiao, Zhang Wei, Wang Weicheng, Wenjie Guo, Liu Wen, Xu Qiang, Gu Yanhong, 2023 PCSK9 inhibition interrupts the cross talk between keratinocytes and macrophages and prevents UVB-induced skin damage, Chao Luan, He Yingxue, Liu Wen, Rong Yicheng, Gao Jian, Xu Kang, Yu Hui, Hu Yu, Zhang Jiaan, Chen Kun, Wenjie Guo, 2023 嘌呤霉素敏感的氨肽酶结构与功能研究进展, 焦晨阳，李艳，徐强，郭文洁, 2023 Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC, Wen Liu, Jiashu Yang, Shihao Fang, Chenyang Jiao, Jianhua Gao, Aihua Zhang, Tiancong Wu, Renxiang Tan, Qiang Xu, Wenjie Guo, 2022 Apo-form selective inhibition of indoleamine-2,3-dioxygenase for tumor immunotherapy, Liu Wen, Zou Yi, Li Kaiming, Zhong Haiqing, Yu Longbo, Ge Shushan, Lai Yisheng, Xianchi Dong, Xu Qiang, Guo Wenjie, 2022 DNA damage repair promotion in colonic epithelial cells by Andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11‒induced intestinal mucositis, Yuanyuan Wang, Bin Wei, Danping Wang, Jingjing Wu, Jianhua Gao, Haiqing Zhong, Yang Sun, Qiang Xu, Wen Liu, Yanhong Gu, Wenjie Guo, 2022 SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer, Wei Bin, Xu Lingyan, Wenjie Guo, Wang Yuanyuan, Wu Jingjing, Li Xiaofei, Cai Xiaomin, Hu Jinbo, Wang Meijing, Xu Qiang, Liu Wen, Gu Yanhong, 2021

Areas of Focus

Mechanisms of inflammation resolution and drug regulation

Publications

Allosterically activating SHP2 using oleanolic acid inhibited the STAT3-Th17 axis and ameliorated colitis, Jinbo Hu, Wen Liu, Yi Zou, Chenyang Jiao, Jiazhen Zhu, Jianjun Zou, Yang Sun, Qiang Xu, Wenjie Guo, 2024
IDO1 inhibition promotes activation of tumor-intrinsic STAT3 pathway and induces adverse tumor-protective effects, Longbo Yu, Lingyan Xu, Yunjie Chen, Yicheng Rong, Yi Zou, Shushan Ge, Tiancong Wu, Yisheng Lai, Qiang Xu, Wenjie Guo, Wen Liu, 2024
A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway, Wu Xiaohan, Xu Lingyan, Li Xiaofei, Zhou Yirui, Han Xiao, Zhang Wei, Wang Weicheng, Wenjie Guo, Liu Wen, Xu Qiang, Gu Yanhong, 2023
PCSK9 inhibition interrupts the cross talk between keratinocytes and macrophages and prevents UVB-induced skin damage, Chao Luan, He Yingxue, Liu Wen, Rong Yicheng, Gao Jian, Xu Kang, Yu Hui, Hu Yu, Zhang Jiaan, Chen Kun, Wenjie Guo, 2023
嘌呤霉素敏感的氨肽酶结构与功能研究进展, 焦晨阳，李艳，徐强，郭文洁, 2023
Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC, Wen Liu, Jiashu Yang, Shihao Fang, Chenyang Jiao, Jianhua Gao, Aihua Zhang, Tiancong Wu, Renxiang Tan, Qiang Xu, Wenjie Guo, 2022
Apo-form selective inhibition of indoleamine-2,3-dioxygenase for tumor immunotherapy, Liu Wen, Zou Yi, Li Kaiming, Zhong Haiqing, Yu Longbo, Ge Shushan, Lai Yisheng, Xianchi Dong, Xu Qiang, Guo Wenjie, 2022
DNA damage repair promotion in colonic epithelial cells by Andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11‒induced intestinal mucositis, Yuanyuan Wang, Bin Wei, Danping Wang, Jingjing Wu, Jianhua Gao, Haiqing Zhong, Yang Sun, Qiang Xu, Wen Liu, Yanhong Gu, Wenjie Guo, 2022
SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer, Wei Bin, Xu Lingyan, Wenjie Guo, Wang Yuanyuan, Wu Jingjing, Li Xiaofei, Cai Xiaomin, Hu Jinbo, Wang Meijing, Xu Qiang, Liu Wen, Gu Yanhong, 2021

Inflammation Resolution Mechanisms Drug Regulation Nlrp3 Cgas Colitis Cancer Therapy

Zhiwei Cao - Tongji University

Zhiwei Cao - Tongji University

Ping Chen - Tongji University

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