Professor | 郭文洁 | 数字化转型顾问

	Upload Avatar (500 x 500)
Name	郭文洁
Contact Information	guowj@nju.edu.cn
Language ability	中文, 英文
Province	江苏

Upload Avatar (500 x 500)

Name

郭文洁

Contact Information

guowj@nju.edu.cn

Language ability

中文, 英文

Province

江苏

University/Lab Affiliation and Title	南京大学
Faculty	Life Sciences
Academic Background & Achievements	2003/09-2007/06 制药工程学士：江苏大学 2007/09-2010/06 生药学硕士：江苏大学 2010/09-2013/06 药理学博士：南京大学成就：教育部自然科学奖一等奖
Work Experience	2013/08-2015/06 - 江苏大学 - 讲师 2015/07-2022/01 - 南京大学 - 副教授 2020/09-至今 - 南京大学 - 博士生导师 2022/01-至今 - 南京大学 - 教授
Awards	2022年：江苏省医学科技奖二等奖 2021年：江苏高校“青蓝工程”优秀教学团队 2019年：中国药理学会-施维雅青年药理学家奖 2018年：江苏省教育教学与研究成果二等奖 2018年：教育部自然科学一等奖 2015年：第十九届“中国药理学会青年药理学家奖” 2015年：南京大学优秀博士学位论文 2015年：江苏省优秀博士学位论文

University/Lab Affiliation and Title

南京大学

Faculty

Life Sciences

Academic Background & Achievements

2003/09-2007/06 制药工程学士：江苏大学
2007/09-2010/06 生药学硕士：江苏大学
2010/09-2013/06 药理学博士：南京大学
成就：教育部自然科学奖一等奖

Work Experience

2013/08-2015/06 - 江苏大学 - 讲师
2015/07-2022/01 - 南京大学 - 副教授
2020/09-至今 - 南京大学 - 博士生导师
2022/01-至今 - 南京大学 - 教授

Awards

2022年：江苏省医学科技奖二等奖
2021年：江苏高校“青蓝工程”优秀教学团队
2019年：中国药理学会-施维雅青年药理学家奖
2018年：江苏省教育教学与研究成果二等奖
2018年：教育部自然科学一等奖
2015年：第十九届“中国药理学会青年药理学家奖”
2015年：南京大学优秀博士学位论文
2015年：江苏省优秀博士学位论文

Areas of Focus	炎症反应消退的机制及药物调控
Publications	Allosterically activating SHP2 using oleanolic acid inhibited the STAT3-Th17 axis and ameliorated colitis, Jinbo Hu, Wen Liu, Yi Zou, Chenyang Jiao, Jiazhen Zhu, Jianjun Zou, Yang Sun, Qiang Xu, Wenjie Guo, 2024 IDO1 inhibition promotes activation of tumor-intrinsic STAT3 pathway and induces adverse tumor-protective effects, Longbo Yu, Lingyan Xu, Yunjie Chen, Yicheng Rong, Yi Zou, Shushan Ge, Tiancong Wu, Yisheng Lai, Qiang Xu, Wenjie Guo, Wen Liu, 2024 A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway, Wu Xiaohan, Xu Lingyan, Li Xiaofei, Zhou Yirui, Han Xiao, Zhang Wei, Wang Weicheng, Wenjie Guo, Liu Wen, Xu Qiang, Gu Yanhong, 2023 PCSK9 inhibition interrupts the cross talk between keratinocytes and macrophages and prevents UVB-induced skin damage, Chao Luan, He Yingxue, Liu Wen, Rong Yicheng, Gao Jian, Xu Kang, Yu Hui, Hu Yu, Zhang Jiaan, Chen Kun, Wenjie Guo, 2023 嘌呤霉素敏感的氨肽酶结构与功能研究进展, 焦晨阳，李艳，徐强，郭文洁, 2023 Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC, Wen Liu, Jiashu Yang, Shihao Fang, Chenyang Jiao, Jianhua Gao, Aihua Zhang, Tiancong Wu, Renxiang Tan, Qiang Xu, Wenjie Guo, 2022 Apo-form selective inhibition of indoleamine-2,3-dioxygenase for tumor immunotherapy, Liu Wen, Zou Yi, Li Kaiming, Zhong Haiqing, Yu Longbo, Ge Shushan, Lai Yisheng, Xianchi Dong, Xu Qiang, Guo Wenjie, 2022 DNA damage repair promotion in colonic epithelial cells by Andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11‒induced intestinal mucositis, Yuanyuan Wang, Bin Wei, Danping Wang, Jingjing Wu, Jianhua Gao, Haiqing Zhong, Yang Sun, Qiang Xu, Wen Liu, Yanhong Gu, Wenjie Guo, 2022 SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer, Wei Bin, Xu Lingyan, Wenjie Guo, Wang Yuanyuan, Wu Jingjing, Li Xiaofei, Cai Xiaomin, Hu Jinbo, Wang Meijing, Xu Qiang, Liu Wen, Gu Yanhong, 2021

Areas of Focus

炎症反应消退的机制及药物调控

Publications

Allosterically activating SHP2 using oleanolic acid inhibited the STAT3-Th17 axis and ameliorated colitis, Jinbo Hu, Wen Liu, Yi Zou, Chenyang Jiao, Jiazhen Zhu, Jianjun Zou, Yang Sun, Qiang Xu, Wenjie Guo, 2024
IDO1 inhibition promotes activation of tumor-intrinsic STAT3 pathway and induces adverse tumor-protective effects, Longbo Yu, Lingyan Xu, Yunjie Chen, Yicheng Rong, Yi Zou, Shushan Ge, Tiancong Wu, Yisheng Lai, Qiang Xu, Wenjie Guo, Wen Liu, 2024
A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway, Wu Xiaohan, Xu Lingyan, Li Xiaofei, Zhou Yirui, Han Xiao, Zhang Wei, Wang Weicheng, Wenjie Guo, Liu Wen, Xu Qiang, Gu Yanhong, 2023
PCSK9 inhibition interrupts the cross talk between keratinocytes and macrophages and prevents UVB-induced skin damage, Chao Luan, He Yingxue, Liu Wen, Rong Yicheng, Gao Jian, Xu Kang, Yu Hui, Hu Yu, Zhang Jiaan, Chen Kun, Wenjie Guo, 2023
嘌呤霉素敏感的氨肽酶结构与功能研究进展, 焦晨阳，李艳，徐强，郭文洁, 2023
Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC, Wen Liu, Jiashu Yang, Shihao Fang, Chenyang Jiao, Jianhua Gao, Aihua Zhang, Tiancong Wu, Renxiang Tan, Qiang Xu, Wenjie Guo, 2022
Apo-form selective inhibition of indoleamine-2,3-dioxygenase for tumor immunotherapy, Liu Wen, Zou Yi, Li Kaiming, Zhong Haiqing, Yu Longbo, Ge Shushan, Lai Yisheng, Xianchi Dong, Xu Qiang, Guo Wenjie, 2022
DNA damage repair promotion in colonic epithelial cells by Andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11‒induced intestinal mucositis, Yuanyuan Wang, Bin Wei, Danping Wang, Jingjing Wu, Jianhua Gao, Haiqing Zhong, Yang Sun, Qiang Xu, Wen Liu, Yanhong Gu, Wenjie Guo, 2022
SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer, Wei Bin, Xu Lingyan, Wenjie Guo, Wang Yuanyuan, Wu Jingjing, Li Xiaofei, Cai Xiaomin, Hu Jinbo, Wang Meijing, Xu Qiang, Liu Wen, Gu Yanhong, 2021

炎症消退机制药物调控 Nlrp3 Cgas 结肠炎癌症治疗

张云芳 - 同济大学

Area of Focus
表观遗传学 | 遗传 | Rna | 修饰 | 调控 | 父系 | 性状 | 机制 | 精子 | 胚胎

毕焱 - 同济大学

Area of Focus
多能性 | 原态 | 人类 | 调控 | 机制 | 类胚胎 | 模型 | 体外 | 构建 | 应用

陈平 - 同济大学

Area of Focus
表观遗传学 | 癌症 | 非编码Rna | 干细胞 | 定向分化 | 胚胎干细胞 | 肝脏组织细胞 | 机制 | 应用 | 研究

View All

Personal Information

Academic Information

Research

联系我们

还未创建账户?

Personal Information

Academic Information

Research

联系我们