Professor | Chao Yan | Asia Growth Partners

Name	Chao Yan
Contact Information	yanchao@nju.edu.cn
Language ability	English, Chinese
Province	Jiangsu

Name

Chao Yan

Contact Information

yanchao@nju.edu.cn

Language ability

English, Chinese

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing University
Faculty	Life Sciences
Academic Background & Achievements	2003 - Bachelor's degree in Biochemistry: Nanjing University 2011 - Ph.D. in Toxicology: University of Colorado Published research in Nature and Molecular Pharmacology Holds a U.S. patent
Work Experience	2011-2015 - University of Colorado Cancer Center - Postdoctoral Research 2016-present - Nanjing University - Professor of Pharmacology, Doctoral Supervisor
Awards	2011 - Best Doctoral Thesis Award, University of Colorado 2011 - National Outstanding Self-financed Student Scholarship 2011 - Carl Smith Award, Society of Toxicology, USA 2011 - Student Travel Award for the 50th Annual Meeting of the Society of Toxicology 2010 - Best Poster Award at the Annual University of Colorado Student Research Forum 2010 - Outstanding Student Poster Presentation (1st Place) at the 28th Annual Meeting of the Mountain West Chapter of the Society of Toxicology 2010 - Student Travel Award for the 28th Annual Meeting of the Mountain West Chapter of the Society of Toxicology 2008 - Best Oral Presentation at the University of Colorado Department of Pharmaceutical Sciences Annual Retreat 2007 - Best Poster Award at the University of Colorado Cancer Center Retreat 2003 - National Scholarship Second Prize

University/Lab Affiliation and Title

Nanjing University

Faculty

Life Sciences

Academic Background & Achievements

2003 - Bachelor's degree in Biochemistry: Nanjing University
2011 - Ph.D. in Toxicology: University of Colorado
Published research in Nature and Molecular Pharmacology
Holds a U.S. patent

Work Experience

2011-2015 - University of Colorado Cancer Center - Postdoctoral Research
2016-present - Nanjing University - Professor of Pharmacology, Doctoral Supervisor

Awards

2011 - Best Doctoral Thesis Award, University of Colorado
2011 - National Outstanding Self-financed Student Scholarship
2011 - Carl Smith Award, Society of Toxicology, USA
2011 - Student Travel Award for the 50th Annual Meeting of the Society of Toxicology
2010 - Best Poster Award at the Annual University of Colorado Student Research Forum
2010 - Outstanding Student Poster Presentation (1st Place) at the 28th Annual Meeting of the Mountain West Chapter of the Society of Toxicology
2010 - Student Travel Award for the 28th Annual Meeting of the Mountain West Chapter of the Society of Toxicology
2008 - Best Oral Presentation at the University of Colorado Department of Pharmaceutical Sciences Annual Retreat
2007 - Best Poster Award at the University of Colorado Cancer Center Retreat
2003 - National Scholarship Second Prize

Areas of Focus	Mechanism of action of small molecule anti-tumor drugs Development of novel targeted drugs
Publications	Drugging the Ral GTPase, Yan C, Jones D, Theodorescu D, 2015 One step closer to targeting RAS, Yan C, Theodorescu D, 2015 Discovery and characterization of small molecules that target the GTPase Ral, Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe EW, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D, 2014 Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells, Inman M, Visconti A, Yan C, Siegel D, Ross D, Moody CJ, 2014 NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones, Siegel D, Yan C, Ross D, 2012 Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin teductase and activation of redox signaling, Yan C, Siegel D, Newsome J, Chilloux A, Moody CJ, Ross D, 2012 Indolequinone inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Characterization of mechanism of inhibition in both cell-free and cellular systems, Yan C, Dufour M, Siegel D, Reigan P, Gomez J, Shieh B, Moody CJ, and Ross D, 2011 Mechanism-based inhibition of quinone reductase 2 (NQO2). Selectivity for NQO2 over NQO1 and structural basis for inhibition, Dufour M, Yan C (co-first author), Colucci MA, Jenner M, Oldham NJ, Gomez J, Reigan P, Siegel D, Li Y, De Matteis CI, Ross D, and Moody CJ, 2011 Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(Allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells, Siegel D, Shieh B, Yan C, Kepa JK, and Ross D, 2011 Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target, Yan C, Shieh B, Reigan P, Zhang Z, Colucci MA, Chilloux A, Newsome JJ, Siegel D, Chan D, Moody CJ, and Ross D, 2009 Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1), Yan C, Kepa JK, Siegel D, Stratford IJ, and Ross D, 2008

Areas of Focus

Mechanism of action of small molecule anti-tumor drugs
Development of novel targeted drugs

Publications

Drugging the Ral GTPase, Yan C, Jones D, Theodorescu D, 2015
One step closer to targeting RAS, Yan C, Theodorescu D, 2015
Discovery and characterization of small molecules that target the GTPase Ral, Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe EW, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D, 2014
Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells, Inman M, Visconti A, Yan C, Siegel D, Ross D, Moody CJ, 2014
NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones, Siegel D, Yan C, Ross D, 2012
Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin teductase and activation of redox signaling, Yan C, Siegel D, Newsome J, Chilloux A, Moody CJ, Ross D, 2012
Indolequinone inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Characterization of mechanism of inhibition in both cell-free and cellular systems, Yan C, Dufour M, Siegel D, Reigan P, Gomez J, Shieh B, Moody CJ, and Ross D, 2011
Mechanism-based inhibition of quinone reductase 2 (NQO2). Selectivity for NQO2 over NQO1 and structural basis for inhibition, Dufour M, Yan C (co-first author), Colucci MA, Jenner M, Oldham NJ, Gomez J, Reigan P, Siegel D, Li Y, De Matteis CI, Ross D, and Moody CJ, 2011
Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(Allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells, Siegel D, Shieh B, Yan C, Kepa JK, and Ross D, 2011
Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target, Yan C, Shieh B, Reigan P, Zhang Z, Colucci MA, Chilloux A, Newsome JJ, Siegel D, Chan D, Moody CJ, and Ross D, 2009
Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1), Yan C, Kepa JK, Siegel D, Stratford IJ, and Ross D, 2008

Small Molecules Anti-Tumor Mechanism Drug Development Targeted Therapy Pharmacology Cancer Research Synthesis Efficacy Toxicology

Huafei Li - Shanghai University

Huafei Li - Shanghai University

Jihui Zhang - University of Chinese Academy of Sciences

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