1994-09--1999-09 Ph.D.: Chinese Academy of Medical Sciences
1988-09--1992-07 Bachelor's: China Pharmaceutical University
2019-10~2024-05 - Institute of Microbiology, Chinese Academy of Sciences - Project Researcher
2013-12~2019-09 - Institute of Microbiology, Chinese Academy of Sciences - Associate Researcher
2003-05~2013-11 - Institute for Infection & Immunity, St George’s, University of London, UK - Postdoctoral, Biological Project Manager
2003-01~2003-04 - University of Paris-sud, France - Postdoctoral
1999-09~2002-05 - Institute of Microbiology, Chinese Academy of Sciences - Postdoctoral
Research
Biosynthesis and regulation of microbial secondary metabolites Development of anti-tumor drugs Development of anti-allergy drugs
New insights into the dihydro-mureidomycin biosynthesis controlled by two unusual proteins in Streptomyces roseosporus, Liu Ning, Xu Yang, Shang Fei, Sun Huiying, Liu Xiang, Huang Ying, Tan Huarong, Zhang Jihui, 2023
Microbial quorum sensing signaling molecules and their roles in the biosynthesis of natural products, Zhang Jihui, Tan Huarong, 2023
Protease allergens as initiators-regulators of allergic inflammation, Wai Tuck Soh, Jihui Zhang, Morley D Hollenberg, Harissios Vliagoftis, Marc E Rothenberg, Caroline L Sokol, Clive Robinson, Alain Jacquet, 2023
An efficient method for targeted cloning of large DNA fragments from Streptomyces, Tian Yuqing, Li Dong, Wang Kai, Wei Baoting, Zhang Jihui, Li Jine, 2023
A butenolide signaling system synergized with biosynthetic gene modules led to effective activation and enhancement of silent oviedomycin production in Streptomyces, Li Junyue, Wang Wenxi, Liu Xiang, Tian Yuqing, Tan Huarong, Zhang Jihui, 2022
A visualization reporter system for characterizing antibiotic biosynthetic gene clusters expression with high-sensitivity, Liu Xiang, Li Jine, Li Yue, Li Junyue, Sun Huiying, Zheng Jiazhen, Zhang Jihui, Tan Huarong, 2022
A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules, Liu Xiang, Wang Wenxi, Li Junyue, Li Yue, Zhang Jihui, Tan Huarong, 2021
Reconstitution of a mini-gene cluster combined with ribosome engineering led to effective enhancement of salinomycin production in Streptomyces albus, Dong Li, Yuqing Tian, Xiang Liu, Wenxi Wang, Yue Li, Huarong Tan, Jihui Zhang, 2020
Component Optimization of Neomycin Biosynthesis via the Reconstitution of a Combinatorial Mini-Gene-Cluster in Streptomyces fradiae, Zheng Jiazhen, Li Yue, Guan Hanye, Li Junyue, Li Dong, Zhang Jihui, Tan Huarong, 2020
Enhancement of salinomycin production by ribosome engineering in Streptomyces albus, Dong Li, Jihui Zhang, Yuqing Tian, Huarong Tan, 2019
Allergen-dependent oxidant formation requires purinoceptor activation of ADAM 10 and prothrombin, Jie Chen, Jihui Zhang, Theresa Tachie-Menson, Neha Shukla, David R. Garrod, Clive Robinson, 2017
Innate Generation of Thrombin and Intracellular Oxidants in Airway Epithelium by Allergen Der p 1, Jihui Zhang, Jie Chen, Kimberley Allen-Philbey, Chathuri Perera Baruhupolage, Theresa Tachie-Menson, Shannon C. Mangat, David R. Garrod, Clive Robinson, 2016
Allergen Delivery Inhibitors: Characterisation of potent and selective inhibitors of Der p 1 and their attenuation of airway responses to House Dust Mite Allergens, Jihui Zhang, Jie Chen, Gary K. Newton, Mark R. Stewart, Trevor R. Perrior, David R. Garrod, Clive Robinson, 2018
Cellular and molecular events in the airway epithelium defining the interaction between House Dust Mite Group 1 allergens and innate defences, Jihui Zhang, Jie Chen, Clive Robinson, 2018
Allergen Delivery Inhibitors: A Rationale for Targeting Sentinel Innate Immune Signaling of Group 1 House Dust Mite Allergens through Structure-Based Protease Inhibitor Design, Jihui Zhang, Jie Chen, Gary K. Newton, Trevor R. Perrior, Clive Robinson, 2018
Pathways of airway oxidant formation by house dust mite allergens and viral RNA converge through myosin motors, pannexons and Toll‐like receptor 4, Jihui Zhang, Jie Chen, Shannon C. Mangat, Chathuri Perera Baruhupolage, David R. Garrod, Clive Robinson, 2018
Identification of a butenolide signaling system that regulates nikkomycin biosynthesis in Streptomyces, Wang Wenxi, Zhang Jihui, Liu Xiang, Li Dong, Li Yue, Tian Yuqing, Tan Huarong, 2018
SWATH label-free proteomics analyses revealed the roles of oxidative stress and antioxidant defensing system in sclerotia formation of Polyporus umbellatus, Li Bing, Tian Xiaofang, Wang Chunlan, Zeng Xu, Xing Yongmei, Ling Hong, Yin Wanqiang, Tian Lixia, Meng Zhixia, Zhang Jihui, Guo Shunxing, 2017
Identification of novel tylosin analogues generated by a wblA disruption mutant in Streptomyces ansochromogenes, Lu Cheng, Liao Guojian, Zhang Jihui, Tan Huarong, 2015
Comparative enzymology of native and recombinant house dust mite allergen Der p 1, Jihui Zhang, JM Saint-Remy, David. R. Garrod, Clive Robinson, 2009
Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases, Jihui Zhang, JM Hamilton, David. R. Garrod, Clive Robinson, 2007
Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy, Jihui Zhang, Jie Chen, Jonathan P Richardson, Nicola-Jane Francis-Newton, Pei F Lai, Kerry Jenkins, Meriel R Major, Rebekah E Key, Mark E Stewart, Stuart Firth-Clark, Steven M Lloyd, Gary K Newton, Trevor R Perrior, David R Garrod, Clive Robinson, 2022
Area of Focus
Protac | Targeted Delivery | Anti-Tumor | Molecular Therapy | Tumor Treatment | Biomedical | Science Popularization | Nanomedicine | Drug Development | Cancer Research
Area of Focus
Small Molecules | Anti-Tumor | Mechanism | Drug Development | Targeted Therapy | Pharmacology | Cancer Research | Synthesis | Efficacy | Toxicology
