Professor | 张集慧 | 数字化转型顾问

	Upload Avatar (500 x 500)
Name	张集慧
Contact Information	zhang.jihui@im.ac.cn
Language ability	中文, 英语
Province	北京

Upload Avatar (500 x 500)

Name

张集慧

Contact Information

zhang.jihui@im.ac.cn

Language ability

中文, 英语

Province

北京

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	1994-09--1999-09 博士: 中国医学科学院 1988-09--1992-07 学士: 中国药科大学
Work Experience	2019-10~2024-05 - 中国科学院微生物研究所 - 项目研究员 2013-12~2019-09 - 中国科学院微生物研究所 - 副研究员 2003-05~2013-11 - 英国伦敦圣乔治大学感染与免疫研究所 - 博士后，生物项目主管 2003-01~2003-04 - 法国巴黎第十一大学 - 博士后 1999-09~2002-05 - 中国科学院微生物研究所 - 博士后

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

1994-09--1999-09 博士: 中国医学科学院
1988-09--1992-07 学士: 中国药科大学

Work Experience

2019-10~2024-05 - 中国科学院微生物研究所 - 项目研究员
2013-12~2019-09 - 中国科学院微生物研究所 - 副研究员
2003-05~2013-11 - 英国伦敦圣乔治大学感染与免疫研究所 - 博士后，生物项目主管
2003-01~2003-04 - 法国巴黎第十一大学 - 博士后
1999-09~2002-05 - 中国科学院微生物研究所 - 博士后

Areas of Focus	微生物次级代谢产物的生物合成与调控抗肿瘤药物研发抗过敏药物研发
Publications	New insights into the dihydro-mureidomycin biosynthesis controlled by two unusual proteins in Streptomyces roseosporus, Liu Ning, Xu Yang, Shang Fei, Sun Huiying, Liu Xiang, Huang Ying, Tan Huarong, Zhang Jihui, 2023 Microbial quorum sensing signaling molecules and their roles in the biosynthesis of natural products, Zhang Jihui, Tan Huarong, 2023 Protease allergens as initiators-regulators of allergic inflammation, Wai Tuck Soh, Jihui Zhang, Morley D Hollenberg, Harissios Vliagoftis, Marc E Rothenberg, Caroline L Sokol, Clive Robinson, Alain Jacquet, 2023 An efficient method for targeted cloning of large DNA fragments from Streptomyces, Tian Yuqing, Li Dong, Wang Kai, Wei Baoting, Zhang Jihui, Li Jine, 2023 A butenolide signaling system synergized with biosynthetic gene modules led to effective activation and enhancement of silent oviedomycin production in Streptomyces, Li Junyue, Wang Wenxi, Liu Xiang, Tian Yuqing, Tan Huarong, Zhang Jihui, 2022 A visualization reporter system for characterizing antibiotic biosynthetic gene clusters expression with high-sensitivity, Liu Xiang, Li Jine, Li Yue, Li Junyue, Sun Huiying, Zheng Jiazhen, Zhang Jihui, Tan Huarong, 2022 A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules, Liu Xiang, Wang Wenxi, Li Junyue, Li Yue, Zhang Jihui, Tan Huarong, 2021 Reconstitution of a mini-gene cluster combined with ribosome engineering led to effective enhancement of salinomycin production in Streptomyces albus, Dong Li, Yuqing Tian, Xiang Liu, Wenxi Wang, Yue Li, Huarong Tan, Jihui Zhang, 2020 Component Optimization of Neomycin Biosynthesis via the Reconstitution of a Combinatorial Mini-Gene-Cluster in Streptomyces fradiae, Zheng Jiazhen, Li Yue, Guan Hanye, Li Junyue, Li Dong, Zhang Jihui, Tan Huarong, 2020 Enhancement of salinomycin production by ribosome engineering in Streptomyces albus, Dong Li, Jihui Zhang, Yuqing Tian, Huarong Tan, 2019 Allergen-dependent oxidant formation requires purinoceptor activation of ADAM 10 and prothrombin, Jie Chen, Jihui Zhang, Theresa Tachie-Menson, Neha Shukla, David R. Garrod, Clive Robinson, 2017 Innate Generation of Thrombin and Intracellular Oxidants in Airway Epithelium by Allergen Der p 1, Jihui Zhang, Jie Chen, Kimberley Allen-Philbey, Chathuri Perera Baruhupolage, Theresa Tachie-Menson, Shannon C. Mangat, David R. Garrod, Clive Robinson, 2016 Allergen Delivery Inhibitors: Characterisation of potent and selective inhibitors of Der p 1

Areas of Focus

微生物次级代谢产物的生物合成与调控
抗肿瘤药物研发
抗过敏药物研发

Publications

New insights into the dihydro-mureidomycin biosynthesis controlled by two unusual proteins in Streptomyces roseosporus, Liu Ning, Xu Yang, Shang Fei, Sun Huiying, Liu Xiang, Huang Ying, Tan Huarong, Zhang Jihui, 2023
Microbial quorum sensing signaling molecules and their roles in the biosynthesis of natural products, Zhang Jihui, Tan Huarong, 2023
Protease allergens as initiators-regulators of allergic inflammation, Wai Tuck Soh, Jihui Zhang, Morley D Hollenberg, Harissios Vliagoftis, Marc E Rothenberg, Caroline L Sokol, Clive Robinson, Alain Jacquet, 2023
An efficient method for targeted cloning of large DNA fragments from Streptomyces, Tian Yuqing, Li Dong, Wang Kai, Wei Baoting, Zhang Jihui, Li Jine, 2023
A butenolide signaling system synergized with biosynthetic gene modules led to effective activation and enhancement of silent oviedomycin production in Streptomyces, Li Junyue, Wang Wenxi, Liu Xiang, Tian Yuqing, Tan Huarong, Zhang Jihui, 2022
A visualization reporter system for characterizing antibiotic biosynthetic gene clusters expression with high-sensitivity, Liu Xiang, Li Jine, Li Yue, Li Junyue, Sun Huiying, Zheng Jiazhen, Zhang Jihui, Tan Huarong, 2022
A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules, Liu Xiang, Wang Wenxi, Li Junyue, Li Yue, Zhang Jihui, Tan Huarong, 2021
Reconstitution of a mini-gene cluster combined with ribosome engineering led to effective enhancement of salinomycin production in Streptomyces albus, Dong Li, Yuqing Tian, Xiang Liu, Wenxi Wang, Yue Li, Huarong Tan, Jihui Zhang, 2020
Component Optimization of Neomycin Biosynthesis via the Reconstitution of a Combinatorial Mini-Gene-Cluster in Streptomyces fradiae, Zheng Jiazhen, Li Yue, Guan Hanye, Li Junyue, Li Dong, Zhang Jihui, Tan Huarong, 2020
Enhancement of salinomycin production by ribosome engineering in Streptomyces albus, Dong Li, Jihui Zhang, Yuqing Tian, Huarong Tan, 2019
Allergen-dependent oxidant formation requires purinoceptor activation of ADAM 10 and prothrombin, Jie Chen, Jihui Zhang, Theresa Tachie-Menson, Neha Shukla, David R. Garrod, Clive Robinson, 2017
Innate Generation of Thrombin and Intracellular Oxidants in Airway Epithelium by Allergen Der p 1, Jihui Zhang, Jie Chen, Kimberley Allen-Philbey, Chathuri Perera Baruhupolage, Theresa Tachie-Menson, Shannon C. Mangat, David R. Garrod, Clive Robinson, 2016
Allergen Delivery Inhibitors: Characterisation of potent and selective inhibitors of Der p 1

生物合成调控微生物次级代谢产物抗肿瘤药物研发抗过敏基因工程蛋白质酶学化合物筛选

赵军 - 上海师范大学

邓子新 - 上海交通大学

张雪洪 - 上海交通大学

View All

Personal Information

Academic Information

Research

联系我们

还未创建账户?

Personal Information

Academic Information

Research

联系我们