2004.09-2009.07 PhD in Cell Biology: Sun Yat-sen University
2007.09-2009.05 Joint PhD in Reproductive Medicine: University of South Florida
2000.09-2004.07 Bachelor's in Biotechnology: Sun Yat-sen University
Published over 65 papers in international journals with an impact factor over 450 and cited over 2500 times
First to correct thalassemia mutation in human embryos using CRISPR/Cas9
2017.07-present - Sun Yat-sen University - Vice Dean, School of Life Sciences
2016.06-present - Sun Yat-sen University - Professor, PhD Supervisor
2016.10-2017.07 - Sun Yat-sen University - Assistant Dean, School of Life Sciences
2011.12-2016.06 - Sun Yat-sen University - Associate Professor
2011.08-2011.11 - Sun Yat-sen University - Lecturer
2009.08-2011.07 - Sun Yat-sen University - Postdoctoral Lecturer
2015: Named one of Nature's 10 people who mattered in science
2015: Recognized as one of the '50 Innovators and Entrepreneurs' by the Center for China and Globalization
2016: Stem Cell Young Investigator Award by the Chinese Stem Cell Society
2018: Invited as an expert for the Global Engineering Frontiers Strategic Consulting Research Project by the Chinese Academy of Engineering
Research
Mechanisms of cell aging and regeneration Research and application of cell gene editing technology Mechanisms of early mammalian embryo development
Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation., Shi G, Bai Y, Zhang X, Su J, Pang J, He Q, Zeng P, Ding J, Xiong Y, Zhang J, Wang J, Liu D, Ma W, Huang J*, Songyang Z*., 2021
Wharton's jelly mesenchymal stem cells embedded in PF-127 hydrogel plus sodium ascorbyl phosphate combination promote diabetic wound healing in type 2 diabetic rat., Jiao Y, Chen X, Niu Y, Huang S, Wang J, Luo M, Shi G*, Huang J*., 2021
Dual-AAV delivering split prime editor system for in vivo genome editing., Zhi S#, Chen Y#, Wu G, Wen J, Wu J, Liu Q, Li Y, Kang R, Hu S, Wang J, Liang P*, Huang J*., 2021
USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy., Liu T, Wang L, Liang P, Wang X, Liu Y, Cai J, She Y, Wang D, Wang Z, Guo Z, Bates S, Xia X, Huang J*, Cui J*., 2021
Two mutations in TUBB8 cause developmental arrest in human oocytes and early embryos., Cao T, Guo J, Xu Y, Lin X, Deng W, Cheng L, Zhao H, Jiang S, Gao M, Huang J*, Xu Y*., 2021
Single AAV-mediated CRISPR/Nme2Cas9 efficiently reduces mutant hTTR expression in a transgenic mouse model of transthyretin amyloidosis., Wen J#, Cao T#, Wu J, Chen Y, Zhi S, Huang Y, Zhen P, Wu G, Aagaard L, Zhong J, Liang P*, Huang J*., 2021
Homology-based repair induced by CRISPR-Cas nucleases in mammalian embryo genome editing., Zhang X, Li T, Ou J*, Huang J*, Liang P*., 2021
Methylation silencing and reactivation of exogenous genes in lentivirus-mediated transgenic mice., Wen J, Wu J, Cao T, Zhi S, Chen Y, Aagaard L, Zhen P, Huang Y, Zhong J*, Huang J*., 2021
Effects of Cigarette Smoking on Preimplantation Embryo Development., Zhan S, Huang J*., 2021
Retrotransposons in pluripotent stem cells., Wang J, Huang J*, Shi G*., 2020
A critical role of telomere chromatin compaction in ALT tumor cell growth., Shi G#, Hu Y#, Zhu X, Jiang Y, Pang J, Wang C, Huang W, Zhao Y, Ma W, Liu D, Huang J*, Songyang Z*., 2020
Single AAV-Mediated CRISPR-SaCas9 Inhibits HSV-1 Replication by Editing ICP4 in Trigeminal Ganglion Neurons., Chen Y#, Zhi S#, Liang P, Zheng Q, Liu M, Zhao Q, Ren J, Cui J, Huang J*, Liu Y*, Songyang Z*., 2020
Development of Highly Efficient Dual-AAV Split Adenosine Base Editor for In Vivo Gene Therapy., Chen Y#, Zhi S#, Liu W#,Wen J#,Hu S, Cao T, Sun H, Li Y, Huang L, Liu Y, Liang P*, Huang J*., 2020
Cost-effective generation of A-to-G mutant mice by zygote electroporation of adenine base editor ribonucleoproteins., Sun H#, Zhi S#, Wu G, Wu G, Cao T, Hao H, Songyang Z*, Liang P*, Huang J*., 2020
PF-127 hydrogel plus sodium ascorbyl phosphate improves Wharton’s jelly mesenchymal stem cells-mediated skin wound healing in mice., Deng Q#, Huang S#, Wen J, Jiao Y, Su X, Shi G*, Huang J*., 2020
Effective generation of maternal genome point mutated porcine embryos by injection of cytosine base editor into germinal vesicle oocytes., Su X#, Chen W#, Cai Q, Liang P, Chen Y, Cong P*, Huang J*., 2020
Off-target effects of cytidine base editor and adenine base editor: What can we do?, Liang P, Wen J, Huang J*., 2019
Production of non-mosaic genome edited porcine embryos by injection of CRISPR/Cas9 into germinal vesicle oocytes., Su X#, Chen W#, Cai Q, Liang P, Chen Y, Cong P*, Huang J*., 2019
The long non-coding RNA Snhg3 is essential for mouse embryonic stem cell self-renewal and pluripotency., Lu W*, Yu J, Shi F, Zhang J, Huang R, Yin S, Songyang Z*, Huang J*., 2019
HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia., Huang Y#, Ding C#, Liang P#, Li D, Tang Y, Meng W, Sun H, Lu H, Chen Y, Chen X, Huang Q, Fang J, Zhou C*, Yang S*, Huang J*., 2019
A novel undifferentiated spermatogonia-specific surface protein 1 (USSP1) in neonatal mice., Lin Z, Liang P, Yao Z, Chen Y, Zhang X, Huang R, Zhang Z, Li M, Ma W, Zheng H, Cao S, Shi G, Zhao X, Songyang Z*, Huang J*., 2019
Off-target challenge for base editor-mediated genome editing., Liang P, Huang J*., 2019
Interaction between Sympk and Oct4 Promotes Mouse Embryonic Stem Cell Proliferation., Yu J#, Lu W#, Ge T, Huang R, Chen B, Ye M, Bai Y, Shi G, Songyang Z, Ma W*, Huang J*., 2019
Genome-wide profiling of adenine base editor specificity by EndoV-seq., Liang P#, Xie X#, Zhi S, Sun H, Zhang X, Chen Y, Chen Y, Xiong Y, Ma W, Liu D, Huang J*, Songyang Z*., 2019
Effective and precise adenine base editing in mouse zygotes., Liang P#, Sun H#, Zhang X, Xie X, Zhang J, Bai Y, Ouyang X, Zhi S, Xiong Y, Ma W, Liu D, Huang J*, Songyang Z*., 2018
Cationic Polymer-Mediated CRISPR/Cas9 Plasmid Delivery for Genome Editing., Zhang Z, Wan T, Chen Y, Chen Y, Sun H, Cao T, Songyang Z, Tang G, Wu C, Ping Y*, Xu FJ*, Huang J*., 2018
Parental genetic material and oxygen concentration affect hatch dynamics of mouse embryo in vitro., Zhan S, Cao S, Du H, Sun Y, Li L, Ding C, Zheng H*, Huang J*., 2018
Testis-specific Lypd9 is dispensable for spermatogenesis in mouse., Feng J, Liang P, Chen Y, Zhang X, Songyang Z, Zheng H, Cao S, Huang J*., 2017
Correction of β-thalassemia mutant by base editor in human embryos., Liang P, Ding C, Sun H, Xie X, Xu Y, Zhang X, Sun Y, Xiong Y, Ma W, Liu Y, Wang Y, Fang J, Liu D, Songyang Z*, Zhou C*, Huang J*., 2017
Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility., Chen Y, Liang P, Huang Y, Li M, Zhang X, Ding C, Feng J, Zhang Z, Zhang X, Gao Y, Zhang Q, Cao S, Zheng H, Liu D, Songyang Z*, Huang J*., 2017
Developmental history and application of CRISPR in human disease., Liang P, Zhang X, Chen Y, Huang J*., 2017
Effective gene editing by high-fidelity base editor 2 in mouse zygotes., Liang P, Sun H, Sun Y, Zhang X, Xie X, Zhang J, Zhang Z, Chen Y, Ding C, Xiong Y, Ma W, Liu D, Huang J*, Songyang Z*., 2017
Rho GDP-dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer., Huang D, Lu W, Zou S, Wang H, Jiang Y, Zhang X, Li P, Songyang Z, Wang L, Wang J, Huang J*, Fang L*., 2017
Assessing Telomerase Activities in Mammalian Cells Using the Quantitative PCR-Based Telomeric Repeat Amplification Protocol (qTRAP)., Jiang S, Tang M, Xin H, Huang J*., 2017
Effective production of recipient male pigs for spermatogonial stem cell transplantation by intratesticular injection with busulfan., Lin Z, Bao J, Kong Q, Bai Y, Luo F, Songyang Z, Wu Y*, Huang J*., 2017
TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses., Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J*, Wang RF*, Cui J*., 2016
Efficient Production of Gene-Modified Mice using Staphylococcus aureus Cas9., Zhang X, Liang P, Ding C, Zhang Z, Zhou J, Xie X, Huang R, Sun Y, Sun H, Zhang J, Xu Y, Songyang Z, Huang J*., 2016
Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX., Hu Y, Shi G*, Zhang L, Li F, Jiang Y, Jiang S, Ma W, Zhao Y, Songyang Z, Huang J*., 2016
Specific Tandem 3'UTR Patterns and Gene Expression Profiles in Mouse Thy1+ Germline Stem Cells., Huang Y, Xiong Y, Lin Z, Feng X, Jiang X, Songyang Z, Huang J*., 2015
CRISPR/Cas9 Promotes Functional Study of Testis Specific X-linked Gene in vivo., Li M, Huang R, Jiang X, Chen Y, Zhang Z, Zhang X, Liang P, Zhan S, Cao S, Songyang Z*, Huang J*., 2015
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes., Liang P, Xu Y, Zhang X, Ding C, Huang R, Zhang Z, Lv J, Xie X, Chen Y, Li Y, Sun Y, Bai Y, Songyang Z, Ma W, Zhou C*, Huang J*., 2015
Actl6a protects embryonic stem cells from differentiating into primitive endoderm., Lu W, Fang L, Ouyang B, Zhang X, Zhan S, Feng X, Bai Y, Han X, Kim H, He Q, Wan M, Shi F, Feng X, Liu D, Huang J*, Songyang Z*., 2015
Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression., Luo Z, Feng X, Wang H, Xu W, Zhao Y, Ma W, Jiang S, Liu D, Huang J*, Songyang Z*., 2015
Telomere regulation in pluripotent stem cells., Huang Y, Liang P, Liu D, Huang J*, Songyang Z*., 2014
TPP1 as a versatile player at the ends of chromosomes., Zhang S, Luo Z, Shi G, Liu D, Songyang Z*, Huang J*., 2014
The telomere-associated homeobox-containing protein TAH1 participates in telomere maintenance in ALT Cells., Feng X, Luo Z, Jiang S, Li F, Han X, Hu Y, Wang D, Zhao Y, Ma W, Liu D, Huang J*, Songyang Z*., 2013
Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke., Huang J, Okuka M, Lu W, Tsibris JC, McLean MP, Keefe DL, Liu L., 2012
Association of telomere length with authentic pluripotency of ES/iPS cells., Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L., 2011
Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro., Huang J, Okuka M, McLean M, Keefe DL, Liu L., 2010
Generation of pluripotent stem cells from eggs of aging mice., Huang J, Okuka M, Wang F, Zuo B, Liang P, Kalmbach K, Liu L, Keefe DL., 2010
Effects of cigarette smoke on fertilization and embryo development in vivo., Huang J, Okuka M, McLean M, Keefe DL, Liu L., 2009
Efficient production of mice from embryonic stem cells injected into four- or eight-cell embryos by piezo micromanipulation., Huang J, Deng K, Wu H, Liu Z, Chen Z, Cao S, Zhou L, Ye X, Keefe DL, Liu L., 2008
Area of Focus
Peptides | Biochemistry | Pharmaceuticals | Drug Development | Pdt | Cancer Research | Molecular Biology | Chemical Synthesis | Protein Engineering | Therapeutics
