2004 - Bachelor of Science: Sun Yat-sen University
2009 - Doctor of Science: Sun Yat-sen University
2011 - Selected for the Ministry of Education's New Century Excellent Talents Support Program
2012 - Promoted to Professor and Doctoral Supervisor
2013 - Funded by the Guangdong Natural Science Outstanding Youth Fund
2014 - Awarded National Excellent Youth Fund
2016 - Appointed as Pearl River Scholar Distinguished Professor
2021 - Selected as Elsevier's Highly Cited Chinese Scholar
2009-2012 - Associate Professor at Sun Yat-sen University
2012-present - Professor at Sun Yat-sen University
2010 - Chinese Society of Immunology Young Scholar Award
2011 - National Excellent Doctoral Dissertation Award
2013 - First Prize in the Ministry of Education's Higher Education Scientific Research Outstanding Achievement Award
2014 - Second Prize in the National Natural Science Award
2019 - First Prize in the Ministry of Education's Higher Education Scientific Research Outstanding Achievement Award
Research
Tumor immune editing and disease progression Inflammatory immune microenvironment B cell biological function Tumor-associated humoral immune response network
Pericancerous Cross-Presentation to Cytotoxic T Lymphocytes Impairs Immunotherapeutic Efficacy in Hepatocellular Carcinoma, Huang CX, Lao XM, Wang XY, Ren YZ, Lu YT, Shi W, Wang YZ, Wu CY, Xu L, Chen MS, Gao Q, Liu L, Wei Y, Kuang DM, 2024
NK-cell-elicited gasdermin-D-dependent hepatocyte pyroptosis induces neutrophil extracellular traps that facilitate HBV-related acute-on-chronic liver failure, Zhao Q, Chen DP, Chen HD, Wang YZ, Shi W, Lu YT, Ren YZ, Wu YK, Pang YH, Deng H, He X, Kuang DM, Guo ZY, 2024
miRNome targeting NF-κB signaling orchestrates macrophage-triggered cancer metastasis and recurrence, Chen DP, Wang JC, Liu ZY, Li PL, Chan KW, Wu XN, Yao WD, Yao T, Kuang DM, Wei Y, 2024
Targeting Ferroptosis-Elicited Inflammation Suppresses Hepatocellular Carcinoma Metastasis and Enhances Sorafenib Efficacy, Mu M, Huang CX, Qu C, Li PL, Wu XN, Yao W, Shen C, Huang R, Wan CC, Jian ZW, Zheng L, Wu RQ, Lao XM, Kuang DM, 2024
Crosstalk between myeloid and B cells shapes the distinct microenvironments of primary and secondary liver cancer, Chen Z, Zhang G, Ren X, Yao Z, Zhou Q, Ren X, Chen S, Xu L, Sun K, Zeng Q, Kuang M, Kuang DM, Peng S, 2023
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment, Lv J, Wei Y, Yin JH, Chen YP, Zhou GQ, Wei C, Liang XY, Zhang Y, Zhang CJ, He SW, He QM, Huang ZL, Guan JL, Shen JY, Li XM, Li JY, Li WF, Tang LL, Mao YP, Guo R, Sun R, Zheng YH, Zhou WW, Xiong KX, Wang SQ, Jin X, Liu N, Li GB, Kuang DM, Sun Y, Ma J, 2023
Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma, Wu RQ, Lao XM, Chen DP, Qin H, Mu M, Cao WJ, Deng J, Wan CC, Zhan WY, Wang JC, Xu L, Chen MS, Gao Q, Zheng L, Wei Y, Kuang DM, 2023
Targeting inflammatory macrophages rebuilds therapeutic efficacy of DOT1L inhibition in hepatocellular carcinoma, Yang YB, Wu CY, Wang XY, Deng J, Cao WJ, Tang YZ, Wan CC, Chen ZT, Zhan WY, Shan H, Kuang DM, Wei Y, 2023
PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma, Wang JC, Chen DP, Lu SX, Chen JB, Wei Y, Liu XC, Tang YH, Zhang R, Chen JC, Kan A, Xu L, Zhang YJ, Hou J, Kuang DM, Chen MS, Zhou ZG, 2022
RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular Carcinoma Progression, Liu T, Gan H, He S, Deng J, Hu X, Li L, Cai L, He J, Long H, Cai J, Li H, Zhang Q, Wang L, Chen F, Chen Y, Zhang H, Li J, Yang L, Liu Y, Yang JH, Kuang DM, Pang P, He H, Shan H, 2022
c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses, Wang XY, Wei Y, Hu B, Liao Y, Wang X, Wan WH, Huang CX, Mahabati M, Liu ZY, Qu JR, Chen XD, Chen DP, Kuang DM, Wang XH, Chen Y, 2022
B cells polarize pathogenic inflammatory T helper subsets through ICOSL-dependent glycolysis, Zeng QH, Wei Y, Lao XM, Chen DP, Huang CX, Lin QY, He M, Liao Y, Li B, Zheng L, Zhang GB, Chen Y, Kuang DM, 2020
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma, Chen YP, Yin JH, Li WF, Li HJ, Lv JW, Wang YQ, Chen DP, Zhang CJ, Li XM, Li JY, Zhang P, Li Y, He Q, Yang X, Lei Y, Tang LL, Zhou GQ, Mao YP, Wei C, Xiong KX, Zhang HB, Zhu SD, Hou Y, Sun Y, Dean M, Amit I, Wu K, Kuang DM, Li G, Liu N, Ma J, 2020
The local immune landscape determines tumor PD-L1 heterogeneity and sensitivity to therapy, Wei Y, Zhao Q, Gao Z, Lao XM, Lin WM, Chen DP, Mu M, Huang CX, Liu ZY, Li B, Zheng L, Kuang DM, 2019
Plasma Cell Polarization to the Immunoglobulin G Phenotype in Hepatocellular Carcinomas Involves Epigenetic Alterations and Promotes Hepatoma Progression in Mice, Wei Y, Lao XM, Xiao X, Wang X, Wu ZJ, Zeng QH, Wu CY, Wu RQ, Chen ZX, Zheng L, Li B, Kuang DM, 2019
Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma, Ouyang FZ, Wu RQ, Wei Y, Liu RX, Yang D, Xiao X, Zheng L, Li B, Lao XM, Kuang DM, 2017
Polarization of Tissue-Resident TFH-Like Cells in Human Hepatoma Bridges Innate Monocyte Inflammation and M2b Macrophage Polarization, Chen MM, Xiao X, Lao XM, Wei Y, Liu RX, Zeng QH, Wang JC, Ouyang FZ, Chen DP, Chan KW, Shi DC, Zheng L, Kuang DM, 2016
PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression, Xiao X, Lao XM, Chen MM, Liu RX, Wei Y, Ouyang FZ, Chen DP, Zhao XY, Zhao Q, Li XF, Liu CL, Zheng L, Kuang DM, 2016
Chemokine (C-X-C motif) receptor 3-positive B cells link interleukin-17 inflammation to protumorigenic macrophage polarization in human hepatocellular carcinoma, Liu RX, Wei Y, Zeng QH, Chan KW, Xiao X, Zhao XY, Chen MM, Ouyang FZ, Chen DP, Zheng L, Lao XM, Kuang DM, 2015
Increased autophagy sustains the survival and pro-tumorigenic effects of neutrophils in human hepatocellular carcinoma, Li XF, Chen DP, Ouyang FZ, Chen MM, Wu Y, Kuang DM, Zheng L, 2015
B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets, Kuang DM, Xiao X, Zhao Q, Chen MM, Li XF, Liu RX, Wei Y, Ouyang FZ, Chen DP, Wu Y, Lao XM, Deng H, Zheng L, 2014
Monocyte/Macrophage-Elicited NK Cell Dysfunction in Hepatocellular Carcinoma Is Mediated by CD48/2B4 Interactions, Wu Y, Kuang DM, Pan WD, Wan YL, Lao XM, Wang D, Li XF, Zheng L, 2013
Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma, Kuang DM, Zhao Q, Wu Y, Peng C, Wang J, Xu Z, Yin XY, Zheng L, 2011
Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote the expansion of memory T helper 17 cells, Kuang DM, Peng C, Zhao Q, Wu Y, Chen M, Zheng L, 2010
Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1, Kuang DM, Zhao Q, Peng C, Xu J, Zhang JP, Wu C, Zheng L, 2009
Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes, Kuang DM, Wu Y, Chen N, Cheng J, Zhuang SM, Zheng L, 2007
Area of Focus
Cell Adhesion | Signaling | Multicellular Organisms | Development | Function | Disease | Chinese Medicine | Active Components | Mechanisms Of Action | Biological Effects
