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Li Cai
Life Science
Sun Yat-Sen University
Guangdong
Language: English, Chinese
Genomics
Bioinformatics
Evolution
Dna Mutations
Regulatory Elements
Biodiversity
Human Diseases
Multi-Omics
Genome Regulation
Molecular Mechanisms
Areas of Focus
- Integration of multi-omics data to study genome regulation and evolution
- Distribution and molecular mechanisms of DNA mutations
- Origin and evolution of genomic regulatory elements
- Impact of molecular mechanisms of genome regulation and evolution on biodiversity or human diseases
Work Experience
- 2019 - Present - Sun Yat-sen University - Established independent research group
- Postdoctoral work at Francis Crick Institute
- Project leader at BGI
Academic Background & Achievements
- 2009 - Bachelor's Degree: Huazhong University of Science and Technology
- 2015 - PhD: University of Copenhagen
- Published in journals like Science, Nature Machine Intelligence, Nature Communications
Publications
- A generalizable deep learning framework for inferring fine-scale germline mutation rate maps., Fang Y*, Deng S*, Li C#, 2022
- High-resolution analysis of cell-state transitions in yeast suggests widespread transcriptional tuning by alternative starts., Chia M*, Li C*, Marques S, Pelechano V, Luscombe NM, van Werven FJ, 2021
- Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome., Li C#, Luscombe NM, 2020
- Integrated analysis sheds light on evolutionary trajectories of young transcription start sites in the human genome., Li C#, Lenhard B, Luscombe NM, 2018
- Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features., Seki R*, Li C*, Fang Q, Hayashi S, Egawa S, Hu J, et al., 2017
- Comparative genomics reveals insights into avian genome evolution and adaptation., Zhang G*, Li C*, Li Q, Li B, Larkin DM, Lee C, et al., 2014
- Molecular traces of alternative social organization in a termite genome., Terrapon N*, Li C*, Robertson HM, Ji L, Meng X, Booth W, et al., 2014
- Two Antarctic penguin genomes reveal insights into their evolutionary history and molecular changes related to the Antarctic environment., Li C*, Zhang Y*, Li J*, Kong L*, Hu H, Pan H, et al., 2014
- The draft genome of a socially polymorphic halictid bee, Lasioglossum albipes., Kocher SD*, Li C*, Yang W, Tan H, Yi SV, Yang X, et al., 2013
- Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques., Yan G*, Zhang G*, Fang X*, Zhang Y*, Li C*, Ling F*, et al., 2011
- The genome of the leaf-cutting ant Acromyrmex echinatior suggests key adaptations to advanced social life and fungus farming., Nygaard S*, Zhang G*, Schiøtt M*, Li C*, Wurm Y, Hu H, et al., 2011
