Professor | Gang Wan | Asia Growth Partners

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Name	Gang Wan
Contact Information	wangang5@mailsysu.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Gang Wan

Contact Information

wangang5@mailsysu.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Sun Yat-Sen University
Faculty	Life Sciences
Academic Background & Achievements	2008-2014 Doctorate: Tsinghua University Selected for the National High-Level Talent Program Published research in journals such as Nature, Nature Cell Biology, EMBO J, Autophagy, and Genetics
Work Experience	2019-present - Sun Yat-sen University, School of Life Sciences - Professor, PI at the National Key Laboratory of Pest Control and Resource Utilization, PI at the Key Laboratory of Gene Function and Regulation 2014-2019 - Harvard Medical School - Postdoctoral Researcher
Awards	Selected for the National High-Level Talent Program Guangdong Province Pearl River Talent Program

University/Lab Affiliation and Title

Sun Yat-Sen University

Faculty

Life Sciences

Academic Background & Achievements

2008-2014 Doctorate: Tsinghua University
Selected for the National High-Level Talent Program
Published research in journals such as Nature, Nature Cell Biology, EMBO J, Autophagy, and Genetics

Work Experience

2019-present - Sun Yat-sen University, School of Life Sciences - Professor, PI at the National Key Laboratory of Pest Control and Resource Utilization, PI at the Key Laboratory of Gene Function and Regulation
2014-2019 - Harvard Medical School - Postdoctoral Researcher

Awards

Selected for the National High-Level Talent Program
Guangdong Province Pearl River Talent Program

Areas of Focus	Non-coding RNA and Epigenetics Molecular Mechanisms of Phase Separation and Membrane-less Organelle Formation and Regulation Physiological and Pathological Functions of Phase Separation and Membrane-less Organelles Optimization and Development of Biotechnology and Synthetic Biology Tools
Publications	HERD-1 mediates multiphase condensate immiscibility to regulate small RNA-driven transgenerational epigenetic inheritance., Changfeng Zhao, Shiyu Cai, Ruona Shi, Xinru Li, Boyuan Deng, Ruofei Li, Shuhan Yang, Jing Huang, Yonglin Liang, Pu Lu, Zhongping Yuan, Haoxiang Jia, Zongjin Jiang, Xiaofei Zhang, Scott Kennedy, Gang Wan, 2024 The human disease-associated gene ZNFX1 controls inflammation through inhibition of the NLRP3 inflammasome., Jing Huang, Yao Wang, Xin Jia, Changfeng Zhao, Meiqi Zhang, Mi Bao, Pan Fu, Cuiqin Cheng, Ruona Shi, Xiaofei Zhang, Jun Cui, Gang Wan, Anlong Xu, 2024 Spatiotemporal regulation of liquid like condensates in epigenetic inheritance., Gang Wan, Brandon D. Fields, George Spracklin, Aditi Shukla, Carolyn M. Phillips, Scott Kennedy, 2018 ZSP-1 is a Z Granule Surface Protein required for Z Granule Fluidity and Germline Immortality., Gang Wan, Lakshya Bajaj, Brandon Fields, Anne E. Dodson, Daniel Pagano, Yuhan Fei, Scott Kennedy, 2021 Technologies for studying phase-separated biomolecular condensates., Boyuan Deng, Gang Wan, 2024 Hypoxia induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway., Gang Wan, Weidong Xie, Zhenyan Liu, Wei Xu, Yuanzhi Lao, Nunu Huang, Kai Cui, Meijian Liao, Jie He, Yuyang Jiang, Burton Yang, Hongxi Xu, Naihan Xu, Yaou Zhang, 2014 The natural compound oblongifolin C inhibits autophagic flux and enhances antitumorefficacy of nutrient deprivation., Yuanzhi Lao, Gang Wan, Zhenyan Liu, Xiaoyu Wang, Ping Ruan, Danqing Xu, Wei Xu, Weidong Xie, Yaou Zhang, Hongxi Xu, Naihan Xu, 2014 A Conserved NRDE-2/MTR-4 Complex Mediates Nuclear RNAi in Caenorhabditis elegans., Gang Wan, Jenny Yan, Yuhan Fei, Daniel J Pagano, Scott Kennedy, 2020 Transgenerational Epigenetic Inheritance Is Negatively Regulated by the HERI-1 Chromodomain Protein., Perales R, Pagano D, Wan G, Fields BD, Saltzman AL, Kennedy SG, 2018 The RNAi Inheritance Machinery of Caenorhabditis elegans., Spracklin G, Fields B, Wan G, Becker D, Wallig A, Shukla A, Kennedy S, 2017 MicroRNA20amediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability., Liu L, He J, Wei X, Wan G, Lao Y, Xu W, Li Z, Hu H, Hu Z, Luo X, Wu J, Xie W, Zhang Y, Xu N, 2017

Areas of Focus

Non-coding RNA and Epigenetics
Molecular Mechanisms of Phase Separation and Membrane-less Organelle Formation and Regulation
Physiological and Pathological Functions of Phase Separation and Membrane-less Organelles
Optimization and Development of Biotechnology and Synthetic Biology Tools

Publications

HERD-1 mediates multiphase condensate immiscibility to regulate small RNA-driven transgenerational epigenetic inheritance., Changfeng Zhao, Shiyu Cai, Ruona Shi, Xinru Li, Boyuan Deng, Ruofei Li, Shuhan Yang, Jing Huang, Yonglin Liang, Pu Lu, Zhongping Yuan, Haoxiang Jia, Zongjin Jiang, Xiaofei Zhang, Scott Kennedy, Gang Wan, 2024
The human disease-associated gene ZNFX1 controls inflammation through inhibition of the NLRP3 inflammasome., Jing Huang, Yao Wang, Xin Jia, Changfeng Zhao, Meiqi Zhang, Mi Bao, Pan Fu, Cuiqin Cheng, Ruona Shi, Xiaofei Zhang, Jun Cui, Gang Wan, Anlong Xu, 2024
Spatiotemporal regulation of liquid like condensates in epigenetic inheritance., Gang Wan, Brandon D. Fields, George Spracklin, Aditi Shukla, Carolyn M. Phillips, Scott Kennedy, 2018
ZSP-1 is a Z Granule Surface Protein required for Z Granule Fluidity and Germline Immortality., Gang Wan, Lakshya Bajaj, Brandon Fields, Anne E. Dodson, Daniel Pagano, Yuhan Fei, Scott Kennedy, 2021
Technologies for studying phase-separated biomolecular condensates., Boyuan Deng, Gang Wan, 2024
Hypoxia induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway., Gang Wan, Weidong Xie, Zhenyan Liu, Wei Xu, Yuanzhi Lao, Nunu Huang, Kai Cui, Meijian Liao, Jie He, Yuyang Jiang, Burton Yang, Hongxi Xu, Naihan Xu, Yaou Zhang, 2014
The natural compound oblongifolin C inhibits autophagic flux and enhances antitumorefficacy of nutrient deprivation., Yuanzhi Lao, Gang Wan, Zhenyan Liu, Xiaoyu Wang, Ping Ruan, Danqing Xu, Wei Xu, Weidong Xie, Yaou Zhang, Hongxi Xu, Naihan Xu, 2014
A Conserved NRDE-2/MTR-4 Complex Mediates Nuclear RNAi in Caenorhabditis elegans., Gang Wan, Jenny Yan, Yuhan Fei, Daniel J Pagano, Scott Kennedy, 2020
Transgenerational Epigenetic Inheritance Is Negatively Regulated by the HERI-1 Chromodomain Protein., Perales R, Pagano D, Wan G, Fields BD, Saltzman AL, Kennedy SG, 2018
The RNAi Inheritance Machinery of Caenorhabditis elegans., Spracklin G, Fields B, Wan G, Becker D, Wallig A, Shukla A, Kennedy S, 2017
MicroRNA20amediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability., Liu L, He J, Wei X, Wan G, Lao Y, Xu W, Li Z, Hu H, Hu Z, Luo X, Wu J, Xie W, Zhang Y, Xu N, 2017

Rna Epigenetics Phase Separation Membrane-Less Organelles Biotechnology Synthetic Biology Gene Expression Non-Coding Rna Rna-Binding Proteins Rna Granules

Jianfeng Chang - Tongji University

You Wu - Tongji University

Zhang Yansheng - Shanghai University

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