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Gang Wan
Life Science
Sun Yat-Sen University
Guangdong
Language: Chinese, English
Rna
Epigenetics
Phase Separation
Membrane-Less Organelles
Biotechnology
Synthetic Biology
Gene Expression
Non-Coding Rna
Rna-Binding Proteins
Rna Granules
Areas of Focus
- Non-coding RNA and Epigenetics
- Molecular Mechanisms of Phase Separation and Membrane-less Organelle Formation and Regulation
- Physiological and Pathological Functions of Phase Separation and Membrane-less Organelles
- Optimization and Development of Biotechnology and Synthetic Biology Tools
Work Experience
- 2019-present - Sun Yat-sen University, School of Life Sciences - Professor, PI at the National Key Laboratory of Pest Control and Resource Utilization, PI at the Key Laboratory of Gene Function and Regulation
- 2014-2019 - Harvard Medical School - Postdoctoral Researcher
Academic Background & Achievements
- 2008-2014 Doctorate: Tsinghua University
- Selected for the National High-Level Talent Program
- Published research in journals such as Nature, Nature Cell Biology, EMBO J, Autophagy, and Genetics
Publications
- HERD-1 mediates multiphase condensate immiscibility to regulate small RNA-driven transgenerational epigenetic inheritance., Changfeng Zhao, Shiyu Cai, Ruona Shi, Xinru Li, Boyuan Deng, Ruofei Li, Shuhan Yang, Jing Huang, Yonglin Liang, Pu Lu, Zhongping Yuan, Haoxiang Jia, Zongjin Jiang, Xiaofei Zhang, Scott Kennedy, Gang Wan, 2024
- The human disease-associated gene ZNFX1 controls inflammation through inhibition of the NLRP3 inflammasome., Jing Huang, Yao Wang, Xin Jia, Changfeng Zhao, Meiqi Zhang, Mi Bao, Pan Fu, Cuiqin Cheng, Ruona Shi, Xiaofei Zhang, Jun Cui, Gang Wan, Anlong Xu, 2024
- Spatiotemporal regulation of liquid like condensates in epigenetic inheritance., Gang Wan, Brandon D. Fields, George Spracklin, Aditi Shukla, Carolyn M. Phillips, Scott Kennedy, 2018
- ZSP-1 is a Z Granule Surface Protein required for Z Granule Fluidity and Germline Immortality., Gang Wan, Lakshya Bajaj, Brandon Fields, Anne E. Dodson, Daniel Pagano, Yuhan Fei, Scott Kennedy, 2021
- Technologies for studying phase-separated biomolecular condensates., Boyuan Deng, Gang Wan, 2024
- Hypoxia induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway., Gang Wan, Weidong Xie, Zhenyan Liu, Wei Xu, Yuanzhi Lao, Nunu Huang, Kai Cui, Meijian Liao, Jie He, Yuyang Jiang, Burton Yang, Hongxi Xu, Naihan Xu, Yaou Zhang, 2014
- The natural compound oblongifolin C inhibits autophagic flux and enhances antitumorefficacy of nutrient deprivation., Yuanzhi Lao, Gang Wan, Zhenyan Liu, Xiaoyu Wang, Ping Ruan, Danqing Xu, Wei Xu, Weidong Xie, Yaou Zhang, Hongxi Xu, Naihan Xu, 2014
- A Conserved NRDE-2/MTR-4 Complex Mediates Nuclear RNAi in Caenorhabditis elegans., Gang Wan, Jenny Yan, Yuhan Fei, Daniel J Pagano, Scott Kennedy, 2020
- Transgenerational Epigenetic Inheritance Is Negatively Regulated by the HERI-1 Chromodomain Protein., Perales R, Pagano D, Wan G, Fields BD, Saltzman AL, Kennedy SG, 2018
- The RNAi Inheritance Machinery of Caenorhabditis elegans., Spracklin G, Fields B, Wan G, Becker D, Wallig A, Shukla A, Kennedy S, 2017
- MicroRNA20amediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability., Liu L, He J, Wei X, Wan G, Lao Y, Xu W, Li Z, Hu H, Hu Z, Luo X, Wu J, Xie W, Zhang Y, Xu N, 2017
Awards
- Selected for the National High-Level Talent Program
- Guangdong Province Pearl River Talent Program
