1987 - Clinical Medicine: Fudan University Shanghai Medical College
1992 - Medical Doctorate in Pediatrics: Fudan University
1999 - PhD in Cell Biology: Linköping University
Published high-level research papers in international journals
Authored highly cited papers and cover stories
Inventor of 15 authorized Chinese patents
1992 - Lecturer: Fudan University National Key Laboratory of Medical Neurobiology
1993-1994 - Visiting Scholar: Leiden University
1995-2002 - Researcher: Linköping University
2000 - Assistant Professor: Linköping University
2002-present - Professor: Sun Yat-sen University
2014 - National Natural Science Award Second Prize
First Prize of Natural Science Award from Ministry of Education and Guangdong Province
Research
Molecular mechanisms of liver cancer development Precision diagnosis and treatment biomarkers for liver cancer
Human macrophages promote the motility and invasiveness of osteopontin- knockdown tumor cells., J Cheng, DH Huo, DM Kuang, J Yang, L Zheng*, SM Zhuang*, 2007
Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes., DM Kuang, Y Wu, N Chen, J Cheng, SM Zhuang*, L Zheng*, 2007
MicroRNA-101, downregulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity., H Su, JR Yang, T Xu, J Huang, L Xu, Y Yuan*, SM Zhuang*, 2009
MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells., T Xu#, Y Zhu#, Y Xiong, YY Ge, JP Yun, SM Zhuang*, 2009
Effects of microRNA-29 on apoptosis, tumorigenicity and prognosis of hepatocellular carcinoma., Y Xiong#, JH Fang#, JP Yun, J Yang, Y Zhang, WH Jia, SM Zhuang*, 2010
A novel GSK-3β-C/EBPα-miR-122-Insuline-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma., C Zeng, R Wang, D Li, XJ Lin, QK Wei, Y Yuan, Q Wang, W Chen, SM Zhuang*, 2010
Identification of Siah-interacting protein as a potential regulator of apoptosis and curcumin resistance., J Luo, J Yang, B-Y Yu, W Liu, M Li, SM Zhuang*, 2010
MicroRNA-29b suppresses tumor angiogenesis, invasion and metastasis by regulating MMP-2 expression., JH Fang, HC Zhou, C Zeng, J Yang, Y Liu, X Huang, JP Zhang, XY Guan, SM Zhuang*, 2011
MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein., Y Zhu#, Y Lu#, Q Zhang, JJ Liu, TJ Li, JR Yang, C Zeng, SM Zhuang*, 2012
MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R., J Gong#, JP Zhang#, BK Li, CX Zeng, KYou, MX Chen, Y Yuan*, SM Zhuang*, 2013
MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2 and CDC42., R Wang, N Zhao, S Li, JH Fang, MX Chen, J Yang, WH Jia, Y Yuan*, SM Zhuang*, 2013
MicroRNA-148a suppresses the epithelial-mesenchymal transition and metastasis of hepatoma cells by targeting Met/Snail signaling., JP Zhang#, C Zeng#, L Xu#, J Gong, JH Fang, SM Zhuang*, 2014
MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3., N Zhao#, R Wang#, L Zhou, Y Zhu, J Gong, SM Zhuang*, 2014
A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells., JJ Liu#, XJ Lin#, X Yang, L Zhou, S He, SM Zhuang*, J Yang*, 2014
A novel vascular pattern promotes metastasis of hepatocellular carcinoma in an EMT-independent manner., JH Fang#, HC Zhou#, C Zhang, LR Shang, L Zhang, J Xu, L Zheng, Y Yuan, RP Guo, WH Jia, JP Yun, MS Chen, Y Zhang, SM Zhuang*, 2015
A serum-microRNA classifier for the early detection of hepatocellular carcinoma: a multicenter, retrospective, longitudinal biomarker identification study with a nested case-control study., XJ Lin#, Y Chong#, ZW Guo#, C Xie, XJ Yang, Q Zhang, SP Li, Y Xiong, Y Yuan, J Min, WH Jia, Y Jie, MS Chen, MX Chen, JH Fang, C Zeng, Y Zhang, RP Guo, Y Wu, G Lin, L Zheng, SM Zhuang*, 2015
MicroRNA-125b and microRNA-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulated tumour clusters., HC Zhou#, JH Fang#, LR Shang, ZJ Zhang, Y Sang, L Xu, Y Yuan, MS Chen, L Zheng, Y Zhang, SM Zhuang*, 2016
Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins., JH Fang*, ZJ Zhang, LR Shang, YW Luo, Y Lin, Y Yuan*, SM Zhuang*, 2018
Vessels that encapsulate tumor clusters (VETC) pattern is a predictor of sorafenib benefit in patients with hepatocellular carcinoma., JH Fang#, L Xu#, LR Shang#, CZ Pan, J Ding, YQ Tang, H Liu, CX Liu, JL Zheng, YJ Zhang, ZG Zhou, J Xu, L Zheng, MS Chen*, SM Zhuang*, 2019
Lnc-UCID promotes G1/S transition and hepatoma growth by preventing DHX9-mediated CDK6 downregulation., YL Wang#, JY Liu#, JE Yang#, XM Yu, ZL Chen, YJ Chen, M Kuang, Y Zhu*, SM Zhuang*, 2019
A hMTR4-PDIA3P1-miR-125/124-TRAF6 Regulatory Axis and Its Function in NF kappa B Signaling and Chemoresistance., C Xie, LZ Zhang, ZL Chen, WJ Zhong, JH Fang, Y Zhu, MH Xiao, ZW Guo, N Zhao, X He, SM Zhuang*, 2020
A p53/lnc-lp53 negative feedback loop regulates tumor growth and chemoresistance., LZ Zhang#, JE Yang#, YW Luo, FT Liu, YF Yuan, SM Zhuang*, 2020
LncRNA lnc-APUE is repressed by HNF4α and promotes G1/S transition and hepatoma growth by regulating miR-20b/E2F1 axis., SY Li, Y Zhu, RN Li, JH Huang, K You, YF Yuan*, SM Zhuang*, 2021
Dual and opposing roles of the androgen receptor in VETC-dependent and invasion-dependent metastasis of hepatocellular carcinoma., HC Zhou, CX Liu, WD Pan, LR Shang, JL Zheng, BY Huang, JY Chen, Ln Zheng, JH Fang*, SM Zhuang*, 2021
Identification of a TGF-β/SMAD/lnc-UTGF positive feedback loop and its role in hepatoma metastasis., MZ Wu, YC Yuan, BY Huang, JX Chen, BK Li, JH Fang*, SM Zhuang*, 2021
