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Lichuang Cao
Life Sciences
Sun Yat-Sen University
Guangdong
Language: Chinese, English
Enzyme Engineering
Synthetic Biology
Extreme Environments
Enzyme Resources
Enzyme Structure
Enzyme Function
Chassis Cell Construction
Biocatalysis
Biotechnology
Molecular Biology
Areas of Focus
- Enzyme Engineering and Synthetic Biology
Work Experience
- 2022/10-present - Sun Yat-sen University - Associate Professor
- 2017/07-2022/08 - Sun Yat-sen University - Postdoctoral Researcher
Academic Background & Achievements
- 2012/09–2017/06 PhD in Microbiology: Sun Yat-sen University
- 2008/09–2012/06 Bachelor's in Bioengineering: Guangdong University of Technology
Publications
- Simultaneously optimizing multiple properties of β-glucosidase Bgl6 using combined (semi-)rational design strategies and investigation of the underlying mechanisms, Shuifeng Li, Lichuang Cao, Xiangpeng Yang, Xiangrui Wu, Shujing Xu, Yuhuan Liu, 2023
- Engineering of β-glucosidase Bgl15 with simultaneously enhanced glucose tolerance and thermostability to improve its performance in high-solid cellulose hydrolysis, Lichuang Cao, Ran Chen, Xin Huang, Shuifeng Li, Sufang Zhang, Xiangpeng Yang, Zongmin Qin, Wei Kong, Wei Xie, Yuhuan Liu, 2020
- Improving galactooligosaccharide synthesis efficiency of β-galactosidase Bgal1-3 by reshaping the active site with an intelligent hydrophobic amino acid scanning, Zongmin Qin, Shuifeng Li, Xin Huang, Wei Kong, Xiangpeng Yang, Sufang Zhang, Lichuang Cao, Yuhuan Liu, 2019
- Improving the cellobiose-hydrolysis activity and glucose-tolerance of a thermostable β-glucosidase through rational design, Xiwen Liu, Lichuang Cao, Jianhua Zeng, Yuhuan Liu, Wei Xie, 2019
- Enhancing the thermostability of highly active and glucose-tolerant β-glucosidase Ks5A7 by directed evolution for good performance of three properties, Lichuang Cao, Shuifeng Li, Xin Huang, Zongmin Qin, Wei Kong, Wei Xie, Yuhuan Liu, 2018
- Tat-independent secretion of polyethylene terephthalate hydrolase PETase in Bacillus subtilis 168 mediated by its native signal peptide, Xin Huang, Lichuang Cao, Zongmin Qin, Shuifeng Li, Wei Kong, Yuhuan Liu, 2018
- Improving the secretion yield of the β-galactosidase Bgal1-3 in Pichia pastoris for use as a potential catalyst in the production of prebiotic-enriched milk, Lichuang Cao, Guanghui Ren, Zongmin Qin, Xin Huang, Wei Kong, Zhijun Wang, Weiqu Liang, Xiaogang Bi, Yuhuan Liu, 2017
- Structures of a glucose-tolerant β-glucosidase provide insights into its mechanism, Panjiao Pang, Lichuang Cao, Yuhuan Liu, Wei Xie, Zhong Wang, 2017
- Engineering of a thermostable esterase Est816 to improve its quorum-quenching activity and the underlying structural basis, Xiwen Liu, Lichuang Cao, Xin-jiong Fan, Yuhuan Liu, Wei Xie, 2016
- Efficient secretion of β-galactosidase Bgal1-3 via both Tat-dependent and Tat-independent pathways in Bacillus subtilis, Guang-hui Ren, Lichuang Cao, Wei Kong, Zhi-jun Wang, Yuhuan Liu, 2016
- Engineering a novel glucose-tolerant β-glucosidase as supplementation to enhance the hydrolysis of sugarcane bagasse at high glucose concentration, Lichuang Cao, Zhi-jun Wang, Guang-hui Ren, Wei Kong, Liang Li, Wei Xie, Yuhuan Liu, 2015
- Enhancing the thermostability of feruloyl esterase EstF27 by directed evolution and the underlying structural basis, Lichuang Cao, Ran Chen, Wei Xie, Yuhuan Liu, 2015
- Characterization of the cross-linked enzyme aggregates of a novel β-galactosidase, a potential catalyst for the synthesis of galacto-oligosaccharides, Liang Li, Gang Li, Lichuang Cao, Guang-hui Ren, Wei Kong, Si-di Wang, Geng-shan Guo, Yuhuan Liu, 2015
- Identification and characterization of an unusual glycosyltransferase-like enzyme with β-galactosidase activity from a soil metagenomic library, Si-di Wang, Geng-shan Guo, Liang Li, Lichuang Cao, Ling Tong, Guang-hui Ren, Yuhuan Liu, 2014
