2013-2018 Ph.D. in Cell Biology: Sun Yat-sen University
2009-2013 B.Sc. in Biotechnology: Sun Yat-sen University
Achievement: Conducted original research on B cells shaping tissue microenvironment and its impact on tumor therapy, published in renowned journals.
2021-present - Sun Yat-sen University, School of Life Sciences - Associate Professor
2018-2021 - Sun Yat-sen University, School of Life Sciences - Postdoctoral Researcher
Research
Tumor Immunology B Lymphocytes Inflammatory Tissue Microenvironment
miRNome targeting NF-κB signaling orchestrates macrophage-triggered cancer metastasis and recurrence., Chen DP, Wang JC, Liu ZY, Li PL, Chan KW, Wu XN, Yao WD, Yao T, Kuang DM, Wei Y., 2024
Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma., Wu RQ, Lao XM, Chen DP, Qin H, Mu M, Cao WJ, Deng J, Wan CC, Zhan WY, Wang JC, Xu L, Chen MS, Gao Q, Zheng L, Wei Y, Kuang DM., 2023
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment., Lv J, Wei Y, Yin JH, Chen YP, Zhou GQ, Wei C, Liang XY, Zhang Y, Zhang CJ, He SW, He QM, Huang ZL, Guan JL, Shen JY, Li XM, Li JY, Li WF, Tang LL, Mao YP, Guo R, Sun R, Zheng YH, Zhou WW, Xiong KX, Wang SQ, Jin X, Liu N, Li GB, Kuang DM, Sun Y, Ma J., 2023
Targeting inflammatory macrophages rebuilds therapeutic efficacy of DOT1L inhibition in hepatocellular carcinoma., Yang YB, Wu CY, Wang XY, Deng J, Cao WJ, Tang YZ, Wan CC, Chen ZT, Zhan WY, Shan H, Kuang DM, Wei Y., 2023
PIM2 Expression Induced by Proinflammatory Macrophages Suppresses Immunotherapy Efficacy in Hepatocellular Carcinoma., Wang JC, Chen DP, Lu SX, Chen JB, Wei Y, Liu XC, Tang YH, Zhang R, Chen JC, Kan A, Xu L, Zhang YJ, Hou J, Kuang DM, Chen MS, Zhou ZG., 2022
c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses., Wang XY, Wei Y, Hu B, Liao Y, Wang X, Wan WH, Huang CX, Mahabati M, Liu ZY, Qu JR, Chen XD, Chen DP, Kuang DM, Wang XH, Chen Y., 2022
Influence of gut and intratumoral microbiota on the immune microenvironment and anti-cancer therapy., Chen Y, Liu B, Wei Y, Kuang DM., 2021
B cell heterogeneity, plasticity, and functional diversity in cancer microenvironments., Wei Y, Huang CX, Xiao X, Chen DP, Shan H, He H, Kuang DM., 2021
PD-L1 Shapes B Cells as Safeguards in Circadian Clock Disorder., Wei Y, Wu CY, Kuang DM., 2021
Immune landscape and therapeutic strategies: new insights into PD-L1 in tumors., Wei Y, Xiao X, Lao XM, Zheng L, Kuang DM., 2021
B cells polarize pathogenic inflammatory T helper subsets through ICOSL-dependent glycolysis., Zeng QH, Wei Y, Lao XM, Chen DP, Huang CX, Lin QY, He M, Liao Y, Zheng L, Li B, Zhang GB, Chen Y, Kuang DM., 2020
The local immune landscape determines tumor PD-L1 heterogeneity and sensitivity to therapy., Wei Y, Zhao Q, Gao Z, Lao XM, Lin WM, Chen DP, Mu M, Huang CX, Liu ZY, Li B, Zheng L, Kuang DM., 2019
Plasma Cell Polarization to the Immunoglobulin G Phenotype in Hepatocellular Carcinomas Involves Epigenetic Alterations and Promotes Hepatoma Progression in Mice., Wei Y, Lao XM, Xiao X, Wang XY, Wu ZJ, Zeng QH, Wu CY, Wu RQ, Chen ZX, Zheng L, Li B, Kuang DM., 2019
Peritumoral monocytes induce cancer cell autophagy to facilitate the progression of human hepatocellular carcinoma., Chen DP, Ning WR, Li XF, Wei Y, Lao XM, Wang JC, Wu Y, Zheng L., 2018
Triptolide inhibits donor-specific antibody production and attenuates mixed antibody-mediated renal allograft injury., Zhao D, Li S, Liao T, Wei Y, Liu M, Han F, Luo Z, Liu X, Sun Q., 2018
Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma., Ouyang FZ, Wu RQ, Wei Y, Liu RX, Yang D, Xiao X, Zheng L, Li B, Lao XM, Kuang DM., 2016
Polarization of Tissue-Resident TFH-Like Cells in Human Hepatoma Bridges Innate Monocyte Inflammation and M2b Macrophage Polarization., Chen MM, Xiao X, Lao XM, Wei Y, Liu RX, Zeng QH, Wang JC, Ouyang FZ, Chen DP, Chan KW, Shi DC, Zheng L, Kuang DM., 2016
PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression., Xiao X, Lao XM, Chen MM, Liu RX, Wei Y, Ouyang FZ, Chen DP, Zhao XY, Zhao Q, Li XF, Liu CL, Zheng L, Kuang DM., 2016
Chemokine (C-X-C motif) receptor 3-positive B cells link interleukin-17 inflammation to protumorigenic macrophage polarization in human hepatocellular carcinoma., Liu RX, Wei Y, Zeng QH, Chan KW, Xiao X, Zhao XY, Chen MM, Ouyang FZ, Chen DP, Zheng L, Lao XM, Kuang DM., 2015
B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets., Kuang DM, Xiao X, Zhao Q, Chen MM, Li XF, Liu RX, Wei Y, Ouyang FZ, Chen DP, Wu Y, Lao XM, Deng H, Zheng L., 2014
Area of Focus
Synergistic | Drug | Computation | Multi-Component | Traditional Chinese Medicine | Cancer | Therapy | Bioinformatics | Network Analysis | Database
