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Bo Shen
national institute of biological sciences，Beijing
National Institute of Biological Sciences，Beijing
Beijing
Language: English, Chinese
Bone Marrow
Microenvironment
Hematological Diseases
Interaction
Mechanisms
Dynamic Changes
Clinical Translation
Basic Research
Diagnosis
Treatment
Areas of Focus
- Mechanisms of interaction between bone marrow microenvironment and hematological diseases
- Dynamic changes in bone marrow microenvironment in hematological diseases
- Clinical translation based on basic medical research
Work Experience
- 2021 - Present: Assistant Investigator, National Institute of Biological Sciences, Beijing
- 2015 - 2021: Postdoctoral Research Fellow, Children's Medical Center Research Institute at UT Southwestern, Dallas, Texas, USA
Academic Background & Achievements
- 2015 - Ph.D. in Pharmacology: University of Illinois College of Medicine, Chicago, Illinois, USA
- 2008 - B.S. in Life Sciences: National University of Singapore, Singapore
- Developed a novel anti-thrombotic drug based on integrin signaling regulation, published in Nature
- Received Dean's Scholarship and Klaus Unna Award from University of Illinois College of Medicine
- Awarded the National Scholarship Council's Outstanding Self-Funded Student Award (Special Excellence Award) in 2014
Publications
- A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis., Shen B, Tasdogan A, Ubellacker JM, Zhang J, Nosyreva ED, Du L, Murphy MM, Hu S, Yi Y, Kara N, Liu X, Guela S, Jia Y, Ramesh V, Embree C, Mitchell EC, Zhao YC, Ju LA, Zhao H, Crane GM, Zhao Z, Syeda R, Morrison SJ., 2021
- Parathyroid hormone promotes osteogenesis partly by promoting Osteolectin expression., Zhang J, Cohen A, Shen B, Du L, Tasdogan A, Zhao Z, Shane EJ, Morrison SJ., 2021
- Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target., Wei H, Xu Y, Wang Y, Xu L, Mo C, Li L, Shen B, Sun Y, Cheng P, Yang L, Pang Y, Qin A, Cao Y, Morrison SJ, Yue R., 2020
- Gli1+ periodontium stem cells are regulated by osteocytes and occlusal force., Men Y, Wang Y, Yi Y, Jing D, Luo W, Chai Y, Ge WP, Shen B, Stenberg W, Feng JQ, Zhao H., 2020
- Lymph protects metastasizing melanoma cells from ferroptosis., Ubellacker JM, Tasdogan A, Ramesh V, Shen B, Mitchell, EC, Martin MS, Gu Z, McCormick ML, Durham AB, Spitz DR, Zhao Z, Mathews TP, Morrison SJ., 2020
- Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles., Gao X, Zhang Z, Mashimo T, Shen B, Nyagilo J, Wang H, Wang Y, Liu Z, Mulgaonkar A, Hu XL, Piccirillo SGM, Eskiocak U, Davé DP, Qin S, Yang Y, Sun X, Fu YX, Zong H, Sun W, Bachoo RM, Ge WP., 2020
- Metabolic heterogeneity confers differences in melanoma metastatic potential., Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A, Murphy MM, Gu Z, Gu W, Martin M, Kasitinon SY, Vandergriff T, Mathews TP, Zhao Z, Schadendorf D, DeBerardinis RJ*, Morrison SJ*., 2020
- Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass., Shen B, Vardy K, Hughes P, Tasdogan A, Zhao Z, Yue R, Crane G, Morrison SJ., 2019
- Clec11a is an osteogenic factor that promotes the maintenance of the adult skeleton., Yue R, Shen B, Morrison SJ., 2016
- Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis., Delaney MK, Kim K, Esteves B, Xu Z, Stojanovic-Terpo A, Shen B, Ushio-Fukai M, Cho J, Du X., 2016
- Signaling-Mediated Cooperativity between Glycoprotein Ib-IX and Protease-Activated Receptors in Thrombin-Induced Platelet Activation., Esteves B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X., 2016
- The interaction of Galpha13 with integrin beta1 mediates cell migration by dynamic regulation of RhoA., Shen B, Esteves B, Kreutz B, Xu Z, Karginov A, Bai Y, Qian F, Norifumi U, Mosher DF, Du X., 2015
- Targeting Integrin and Integrin Signaling in Treating Thrombosis., Esteves B, Shen B, Du X., 2015
- Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism., Delaney MK, Liu L, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X., 2014
- A mechanism for the directional switch of integrin signaling and selective inhibition of outside-in signaling as a new anti-thrombotic strategy., Shen B, Zhao X, O’Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SCT, Du X., 2013
- Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction., Shen B, Delaney MK, Du X., 2012
- G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin 'outside-in' signaling., Gong H, Shen B, Flevaris P, Chow C, Lam SCT, Voyno-Yasenetskaya TA, Kozasa T, Du X., 2010
- Niches that regulate stem cells and hematopoiesis in adult bone marrow., Stefano C#, Shen B#, Morrison SJ., 2021
- Targeting Integrin and Integrin Signaling in Treating Thrombosis., Esteves B, Shen B, Du X., 2015
- Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction., Shen B, Delaney MK, Du X., 2012
Awards
- 2017: NIH Postdoctoral Fellowship (F32)
- 2014: National Scholarship Council's Outstanding Self-Funded Student Award (Special Excellence Award)
- 2014: Klaus Unna Award, University of Illinois College of Medicine
- 2013: Dean's Scholarship, University of Illinois College of Medicine
