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沈博
national institute of biological sciences，Beijing
北京生命科学研究所
北京
Language: 英语, 中文
骨髓
微环境
血液疾病
相互作用
机制
动态变化
临床转化
基础研究
诊断
治疗
Areas of Focus
- 骨髓微环境与血液疾病相互作用的机制
- 骨髓微环境在血液疾病中的动态变化
- 基于基础医学研究的临床转化
Work Experience
- 2021年至今: 北京生命科学研究所研究员
- 2015年至2021年: 美国德克萨斯大学西南医学研究中心博士后研究员
Academic Background & Achievements
- 2015年 - 药理学博士: 美国伊利诺伊大学医学院
- 2008年 - 生命科学学士: 新加坡国立大学
- 开发了基于整合素信号传导调控的新型抗血栓药物，成果发表于Nature
- 获得伊利诺伊大学医学院院长奖学金和Klaus Unna奖
- 2014年获得国家留学基金委优秀自费留学生奖（特别优秀奖）
Publications
- A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis., Shen B, Tasdogan A, Ubellacker JM, Zhang J, Nosyreva ED, Du L, Murphy MM, Hu S, Yi Y, Kara N, Liu X, Guela S, Jia Y, Ramesh V, Embree C, Mitchell EC, Zhao YC, Ju LA, Zhao H, Crane GM, Zhao Z, Syeda R, Morrison SJ., 2021
- Parathyroid hormone promotes osteogenesis partly by promoting Osteolectin expression., Zhang J, Cohen A, Shen B, Du L, Tasdogan A, Zhao Z, Shane EJ, Morrison SJ., 2021
- Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target., Wei H, Xu Y, Wang Y, Xu L, Mo C, Li L, Shen B, Sun Y, Cheng P, Yang L, Pang Y, Qin A, Cao Y, Morrison SJ, Yue R., 2020
- Gli1+ periodontium stem cells are regulated by osteocytes and occlusal force., Men Y, Wang Y, Yi Y, Jing D, Luo W, Chai Y, Ge WP, Shen B, Stenberg W, Feng JQ, Zhao H., 2020
- Lymph protects metastasizing melanoma cells from ferroptosis., Ubellacker JM, Tasdogan A, Ramesh V, Shen B, Mitchell, EC, Martin MS, Gu Z, McCormick ML, Durham AB, Spitz DR, Zhao Z, Mathews TP, Morrison SJ., 2020
- Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles., Gao X, Zhang Z, Mashimo T, Shen B, Nyagilo J, Wang H, Wang Y, Liu Z, Mulgaonkar A, Hu XL, Piccirillo SGM, Eskiocak U, Davé DP, Qin S, Yang Y, Sun X, Fu YX, Zong H, Sun W, Bachoo RM, Ge WP., 2020
- Metabolic heterogeneity confers differences in melanoma metastatic potential., Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A, Murphy MM, Gu Z, Gu W, Martin M, Kasitinon SY, Vandergriff T, Mathews TP, Zhao Z, Schadendorf D, DeBerardinis RJ*, Morrison SJ*., 2020
- Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass., Shen B, Vardy K, Hughes P, Tasdogan A, Zhao Z, Yue R, Crane G, Morrison SJ., 2019
- Clec11a is an osteogenic factor that promotes the maintenance of the adult skeleton., Yue R, Shen B, Morrison SJ., 2016
- Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis., Delaney MK, Kim K, Esteves B, Xu Z, Stojanovic-Terpo A, Shen B, Ushio-Fukai M, Cho J, Du X., 2016
- Signaling-Mediated Cooperativity between Glycoprotein Ib-IX and Protease-Activated Receptors in Thrombin-Induced Platelet Activation., Esteves B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X., 2016
- The interaction of Galpha13 with integrin beta1 mediates cell migration by dynamic regulation of RhoA., Shen B, Esteves B, Kreutz B, Xu Z, Karginov A, Bai Y, Qian F, Norifumi U, Mosher DF, Du X., 2015
- Targeting Integrin and Integrin Signaling in Treating Thrombosis., Esteves B, Shen B, Du X., 2015
- Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism., Delaney MK, Liu L, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X., 2014
- A mechanism for the directional switch of integrin signaling and selective inhibition of outside-in signaling as a new anti-thrombotic strategy., Shen B, Zhao X, O’Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SCT, Du X., 2013
- Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction., Shen B, Delaney MK, Du X., 2012
- G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin 'outside-in' signaling., Gong H, Shen B, Flevaris P, Chow C, Lam SCT, Voyno-Yasenetskaya TA, Kozasa T, Du X., 2010
- Niches that regulate stem cells and hematopoiesis in adult bone marrow., Stefano C#, Shen B#, Morrison SJ., 2021
- Targeting Integrin and Integrin Signaling in Treating Thrombosis., Esteves B, Shen B, Du X., 2015
- Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction., Shen B, Delaney MK, Du X., 2012
Awards
- 2017年: 美国国立卫生研究院博士后基金（F32）
- 2014年: 国家留学基金委优秀自费留学生奖（特别优秀奖）
- 2014年: 伊利诺伊大学药理学系Klaus Unna奖
- 2013年: 伊利诺伊大学医学院院长奖学金
