Professor | Haibo Zhou | Asia Growth Partners

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Name	Haibo Zhou
Contact Information	hbzhou@@ion.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Haibo Zhou

Contact Information

hbzhou@@ion.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Chinese Academy of Sciences
Faculty	institute of neuroscience Chinese academy of sciences
Academic Background & Achievements	2009 - Bachelor of Science: Jilin University 2012 - Master of Neuroscience: Erasmus University Rotterdam 2014 - PhD in Neuroscience: Erasmus University Rotterdam
Work Experience	2015-2020 - Postdoctoral Research: Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology 2020-Present - Research Group Leader: Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology

University/Lab Affiliation and Title

Chinese Academy of Sciences

Faculty

institute of neuroscience Chinese academy of sciences

Academic Background & Achievements

2009 - Bachelor of Science: Jilin University
2012 - Master of Neuroscience: Erasmus University Rotterdam
2014 - PhD in Neuroscience: Erasmus University Rotterdam

Work Experience

2015-2020 - Postdoctoral Research: Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology
2020-Present - Research Group Leader: Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology

Areas of Focus	Development and optimization of gene editing tools Application of gene editing technology in treating major neurological diseases
Publications	Generation of rat forebrain tissues in mice, Huang, J., He, B., Yang, X., Long, X., Wei, Y., Li, L., Tang, M., Gao, Y., Fang, Y., Ying, W., Wang, Z., Li, C., Zhou, Y., Li, S., Shi, L., Choi, S., Zhou, H., Guo, F., Yang, H.* and Wu, J., 2024 Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice, Zhang, L., Jia, Z., Wu, Q., Bai, T., Wang, B., Hu, X., Li, T., Liu, X., Fu, J., Chen, Y., Ding, X., Liu, Z., Xu, Z., & Zhou, H., 2023 Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs, Gao, N., Hu, J., He, B., Ji, Z., Hu, X., Huang, J., Wei, Y., Peng, J., Wei, Y., Zhou, Y., Shen, X., Li, H., Feng, X., Xiao, Q., Shi, L., Sun, Y., Zhou, C., Zhou, H. & Yang, H., 2021 Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice, Zhou, H., Su, J., Hu, X., Zhou, C., Li, H., Chen, Z., Xiao, Q., Wang, B., Wu, W., Sun, Y., Zhou, Y., Tang, C., Liu, F., Wang, L., Feng, C., Liu, M., Li, S., Zhang, Y., Xu, H., Yao, H., Shi, L., Yang, H., 2020 CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration, Zhou, C., Hu, X., Tang, C., Liu, W., Wang, S., Zhou, Y., Zhao, Q., Bo, Q., Shi, L., Sun, X., Zhou, H., Yang, H., 2020 Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis, Zhou, C., Sun, Y., Yan, R., Liu, Y., Zuo, E., Gu, C., Han, L., Wei Y., Zeng, R., Li, Y., Zhou, H., Guo F., Yang H., 2019 In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR/dCas9-activator transgenic mice, Zhou, H., Liu, J., Zhou, C., Gao, N., Rao, Z., Li, H., Hu, X., Li, C., Yao, X., Shen, X., Sun, Y., Wei, Y., Liu, F., Ying, W., Zhang, J., Tang, C., Zhang, X., Xu, H., Shi, L., Cheng, L., Huang, P., Yang, H., 2018 Homology-mediated end joining-based targeted integration using CRISPR/Cas9, Yao, X., Wang, X., Hu, X., Liu, Z., Liu, J., Zhou, H., Shen, X., Wei, Y., Huang, Z., Ying, W., Wang, Y., Nie, YH., Zhang, CC., Li, S., Cheng, L., Wang, Q., Wu, Y., Huang, P., Sun, Q., Shi, L., Yang, H., 2017 Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice, Peter, S., Ten, M., Stedehouder, J., Reinelt, M., Wu, B., Zhou, H., Zhou, K., Boele, H. J., Kushner, S. A., Lee, M. G., Schmeisser, M. J., Boeckers, T. M., Schonewille, M., Hoebeek, F. E. & De Zeeuw, C. I., 2016 Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules, Zhou, H., Voges, K., Lin, Z., Ju, C. & Schonewille, M., 2015 Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis, Sepulveda, D., Barrera-Ocampo, A., Hagel, C., Korwitz, A., Vinueza, M. F., Zhou, K., Schonewille, M., Zhou, H., Velazquez-Perez, L., Rodriguez, R., Villegas, A., Ferrer, I., Lopera, F., Langer, T., De Zeeuw, C. I. & Glatzel, M., 2014 Cerebellar modules operate at different frequencies, Zhou, H., Lin, Z., Voges, K., Ju, C., Gao, Z., Bosman, L. W., Ruigrok, T. J., Hoebeek, F. E., De Zeeuw, C. I. & Schonewille, M.*, 2014

Areas of Focus

Development and optimization of gene editing tools
Application of gene editing technology in treating major neurological diseases

Publications

Generation of rat forebrain tissues in mice, Huang, J., He, B., Yang, X., Long, X., Wei, Y., Li, L., Tang, M., Gao, Y., Fang, Y., Ying, W., Wang, Z., Li, C., Zhou, Y., Li, S., Shi, L., Choi, S., Zhou, H.*, Guo, F.*, Yang, H.* and Wu, J.*, 2024
Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice, Zhang, L., Jia, Z., Wu, Q., Bai, T., Wang, B., Hu, X., Li, T., Liu, X., Fu, J., Chen, Y., Ding, X., Liu, Z., Xu, Z.*, & Zhou, H.*, 2023
Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs, Gao, N., Hu, J., He, B., Ji, Z., Hu, X., Huang, J., Wei, Y., Peng, J., Wei, Y., Zhou, Y., Shen, X., Li, H., Feng, X., Xiao, Q., Shi, L., Sun, Y., Zhou, C., Zhou, H.* & Yang, H.*, 2021
Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice, Zhou, H.*, Su, J., Hu, X., Zhou, C., Li, H., Chen, Z., Xiao, Q., Wang, B., Wu, W., Sun, Y., Zhou, Y., Tang, C., Liu, F., Wang, L., Feng, C., Liu, M., Li, S., Zhang, Y., Xu, H., Yao, H., Shi, L., Yang, H.*, 2020
CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration, Zhou, C., Hu, X., Tang, C., Liu, W., Wang, S., Zhou, Y., Zhao, Q., Bo, Q., Shi, L., Sun, X.*, Zhou, H.*, Yang, H.*, 2020
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis, Zhou, C., Sun, Y., Yan, R., Liu, Y., Zuo, E., Gu, C., Han, L., Wei Y., Zeng, R., Li, Y.*, Zhou, H.*, Guo F.*, Yang H.*, 2019
In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR/dCas9-activator transgenic mice, Zhou, H., Liu, J., Zhou, C., Gao, N., Rao, Z., Li, H., Hu, X., Li, C., Yao, X., Shen, X., Sun, Y., Wei, Y., Liu, F., Ying, W., Zhang, J., Tang, C., Zhang, X., Xu, H., Shi, L., Cheng, L., Huang, P.*, Yang, H.*, 2018
Homology-mediated end joining-based targeted integration using CRISPR/Cas9, Yao, X., Wang, X., Hu, X., Liu, Z., Liu, J., Zhou, H., Shen, X., Wei, Y., Huang, Z., Ying, W., Wang, Y., Nie, YH., Zhang, CC., Li, S., Cheng, L., Wang, Q., Wu, Y., Huang, P., Sun, Q., Shi, L., Yang, H.*, 2017
Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice, Peter, S., Ten, M., Stedehouder, J., Reinelt, M., Wu, B., Zhou, H., Zhou, K., Boele, H. J., Kushner, S. A., Lee, M. G., Schmeisser, M. J., Boeckers, T. M., Schonewille, M., Hoebeek, F. E.* & De Zeeuw, C. I.*, 2016
Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules, Zhou, H., Voges, K., Lin, Z., Ju, C.* & Schonewille, M.*, 2015
Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis, Sepulveda, D., Barrera-Ocampo, A., Hagel, C., Korwitz, A., Vinueza, M. F., Zhou, K., Schonewille, M., Zhou, H., Velazquez-Perez, L., Rodriguez, R., Villegas, A., Ferrer, I., Lopera, F., Langer, T., De Zeeuw, C. I.* & Glatzel, M.*, 2014
Cerebellar modules operate at different frequencies, Zhou, H., Lin, Z., Voges, K., Ju, C., Gao, Z., Bosman, L. W., Ruigrok, T. J., Hoebeek, F. E., De Zeeuw, C. I.* & Schonewille, M.*, 2014

Crispr Gene Editing Dna Rna Neurological Diseases Alzheimer'S Parkinson'S Bioinformatics Gene Therapy Neuroscience

Yongyong Shi - Chinese Academy of Sciences

Yi Di Sun - Chinese Academy of Sciences

Jun Yan - Chinese Academy of Sciences

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