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Haibo Zhou
Neuroscience Chinese academy of sciences
Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Crispr
Gene Editing
Dna
Rna
Neurological Diseases
Alzheimer'S
Parkinson'S
Bioinformatics
Gene Therapy
Neuroscience
Areas of Focus
- Development and optimization of gene editing tools
- Application of gene editing technology in treating major neurological diseases
Work Experience
- 2015-2020 - Postdoctoral Research: Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology
- 2020-Present - Research Group Leader: Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology
Academic Background & Achievements
- 2009 - Bachelor of Science: Jilin University
- 2012 - Master of Neuroscience: Erasmus University Rotterdam
- 2014 - PhD in Neuroscience: Erasmus University Rotterdam
Publications
- Generation of rat forebrain tissues in mice, Huang, J., He, B., Yang, X., Long, X., Wei, Y., Li, L., Tang, M., Gao, Y., Fang, Y., Ying, W., Wang, Z., Li, C., Zhou, Y., Li, S., Shi, L., Choi, S., Zhou, H.*, Guo, F.*, Yang, H.* and Wu, J.*, 2024
- Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice, Zhang, L., Jia, Z., Wu, Q., Bai, T., Wang, B., Hu, X., Li, T., Liu, X., Fu, J., Chen, Y., Ding, X., Liu, Z., Xu, Z.*, & Zhou, H.*, 2023
- Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs, Gao, N., Hu, J., He, B., Ji, Z., Hu, X., Huang, J., Wei, Y., Peng, J., Wei, Y., Zhou, Y., Shen, X., Li, H., Feng, X., Xiao, Q., Shi, L., Sun, Y., Zhou, C., Zhou, H.* & Yang, H.*, 2021
- Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice, Zhou, H.*, Su, J., Hu, X., Zhou, C., Li, H., Chen, Z., Xiao, Q., Wang, B., Wu, W., Sun, Y., Zhou, Y., Tang, C., Liu, F., Wang, L., Feng, C., Liu, M., Li, S., Zhang, Y., Xu, H., Yao, H., Shi, L., Yang, H.*, 2020
- CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration, Zhou, C., Hu, X., Tang, C., Liu, W., Wang, S., Zhou, Y., Zhao, Q., Bo, Q., Shi, L., Sun, X.*, Zhou, H.*, Yang, H.*, 2020
- Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis, Zhou, C., Sun, Y., Yan, R., Liu, Y., Zuo, E., Gu, C., Han, L., Wei Y., Zeng, R., Li, Y.*, Zhou, H.*, Guo F.*, Yang H.*, 2019
- In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR/dCas9-activator transgenic mice, Zhou, H., Liu, J., Zhou, C., Gao, N., Rao, Z., Li, H., Hu, X., Li, C., Yao, X., Shen, X., Sun, Y., Wei, Y., Liu, F., Ying, W., Zhang, J., Tang, C., Zhang, X., Xu, H., Shi, L., Cheng, L., Huang, P.*, Yang, H.*, 2018
- Homology-mediated end joining-based targeted integration using CRISPR/Cas9, Yao, X., Wang, X., Hu, X., Liu, Z., Liu, J., Zhou, H., Shen, X., Wei, Y., Huang, Z., Ying, W., Wang, Y., Nie, YH., Zhang, CC., Li, S., Cheng, L., Wang, Q., Wu, Y., Huang, P., Sun, Q., Shi, L., Yang, H.*, 2017
- Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice, Peter, S., Ten, M., Stedehouder, J., Reinelt, M., Wu, B., Zhou, H., Zhou, K., Boele, H. J., Kushner, S. A., Lee, M. G., Schmeisser, M. J., Boeckers, T. M., Schonewille, M., Hoebeek, F. E.* & De Zeeuw, C. I.*, 2016
- Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules, Zhou, H., Voges, K., Lin, Z., Ju, C.* & Schonewille, M.*, 2015
- Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis, Sepulveda, D., Barrera-Ocampo, A., Hagel, C., Korwitz, A., Vinueza, M. F., Zhou, K., Schonewille, M., Zhou, H., Velazquez-Perez, L., Rodriguez, R., Villegas, A., Ferrer, I., Lopera, F., Langer, T., De Zeeuw, C. I.* & Glatzel, M.*, 2014
- Cerebellar modules operate at different frequencies, Zhou, H., Lin, Z., Voges, K., Ju, C., Gao, Z., Bosman, L. W., Ruigrok, T. J., Hoebeek, F. E., De Zeeuw, C. I.* & Schonewille, M.*, 2014
