Professor | Guodong Shen | Asia Growth Partners

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Name	Guodong Shen
Contact Information	gdshen@ustc.edu.cn
Language ability	Chinese, English
Province	Anhui

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Name

Guodong Shen

Contact Information

gdshen@ustc.edu.cn

Language ability

Chinese, English

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Mayo Clinic College of Medicine
Academic Background & Achievements	2007/09–2010/07 PhD in Pharmacology: Anhui Medical University 2010/08–2012/07 Postdoctoral in Cell Biology: University of Science and Technology of China
Work Experience	2012/08–2014/02 - Anhui Provincial Hospital - Director of Molecular Medicine Laboratory 2014/03–2014/09 - Nagoya University, Japan - Senior Researcher 2014/09–Present - Anhui Provincial Hospital - Director of Molecular Medicine Laboratory
Awards	Anhui Science and Technology Award (2022): Third Prize Anhui Science and Technology Award (2018): Second Prize Anhui Science and Technology Award (2014): Second Prize Anhui Youth Science and Technology Award (2013): No rank Anhui Science and Technology Award (2012): Second Prize

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Mayo Clinic College of Medicine

Academic Background & Achievements

2007/09–2010/07 PhD in Pharmacology: Anhui Medical University
2010/08–2012/07 Postdoctoral in Cell Biology: University of Science and Technology of China

Work Experience

2012/08–2014/02 - Anhui Provincial Hospital - Director of Molecular Medicine Laboratory
2014/03–2014/09 - Nagoya University, Japan - Senior Researcher
2014/09–Present - Anhui Provincial Hospital - Director of Molecular Medicine Laboratory

Awards

Anhui Science and Technology Award (2022): Third Prize
Anhui Science and Technology Award (2018): Second Prize
Anhui Science and Technology Award (2014): Second Prize
Anhui Youth Science and Technology Award (2013): No rank
Anhui Science and Technology Award (2012): Second Prize

Areas of Focus	Mechanism and targeted therapy of gastric cancer and other geriatric tumors Mechanism and prevention of sarcopenia in the elderly Mechanism and targeted therapy of tumor-induced skeletal muscle reduction
Publications	An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity., Cheng L, Zhu M, Gao Y, Liu W, Yin W, Zhou P, Zhu Z, Niu L, Zeng X, Zhang D, Fang Q, Wang F, Zhao Q, Zhang Y (), Shen G (), 2023 A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity., Cheng L, Cheng Y, Liu W, Shen A, Zhang D, Xu T, Yin W, Cheng M, Ma X(), Wang F, Zhao Q, Zeng X, Zhang Y(), Shen G (), 2022 Beyond emotion: online takeaway food consumption is associated with emotional overeating among Chinese college students., Zhang Y(), Hou F, Yang S, Li J, Zha X (), Shen G (), 2022 The association between leftover food consumption and depression among older adults: Findings from a cross-sectional study., Zhang Y, Hou F, Cheng J, Chen G, Wang L, Jiang X(), Chen R(), Shen G (), 2022 Depressive symptoms and cognitive decline among Chinese rural elderly individuals: A longitudinal study with 2-year follow-up., Zhou S, Wang Q, Zhang J, Wang Q, Hou F, Han X, Hu S, Shen G (), Zhang Y (), 2022 A WNT7B-m6A-TCF7L2 positive feedback loop promotes gastric cancer progression and metastasis., Gao Q, Yang L, Shen A, Li Y, Li Y, Hu S, Yang R, Wang X, Yao X(), Shen G (), 2021 ICG-loaded PEG-modified black phosphorus nanosheets for fluorescence imaging-guided breast cancer therapy., Pan W, Chen W, Min Y, Wang J, Yang Z (), Xu T, Yu F, Shen G (). Hu Y (), MA X (), 2021 The Wnt3a/β-catenin/TCF7L2 signaling axis reduces the sensitivity of HER2-positive epithelial ovarian cancer to trastuzumab., Shen G (#) (), Gao Q (#), Liu F (#), Zhang Y, Dai M, Zhao T, Cheng M, Xu T, Jin P, Yin W, Huang D, Weng H, Chen W, Ren H, Mu X, Wu X, Hu S(*), 2020

Areas of Focus

Mechanism and targeted therapy of gastric cancer and other geriatric tumors
Mechanism and prevention of sarcopenia in the elderly
Mechanism and targeted therapy of tumor-induced skeletal muscle reduction

Publications

An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity., Cheng L, Zhu M, Gao Y, Liu W, Yin W, Zhou P, Zhu Z, Niu L, Zeng X, Zhang D, Fang Q, Wang F, Zhao Q, Zhang Y (*), Shen G (*), 2023
A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity., Cheng L, Cheng Y, Liu W, Shen A, Zhang D, Xu T, Yin W, Cheng M, Ma X(*), Wang F, Zhao Q, Zeng X, Zhang Y(*), Shen G (*), 2022
Beyond emotion: online takeaway food consumption is associated with emotional overeating among Chinese college students., Zhang Y(*), Hou F, Yang S, Li J, Zha X (*), Shen G (*), 2022
The association between leftover food consumption and depression among older adults: Findings from a cross-sectional study., Zhang Y, Hou F, Cheng J, Chen G, Wang L, Jiang X(*), Chen R(*), Shen G (*), 2022
Depressive symptoms and cognitive decline among Chinese rural elderly individuals: A longitudinal study with 2-year follow-up., Zhou S, Wang Q, Zhang J, Wang Q, Hou F, Han X, Hu S, Shen G (*), Zhang Y (*), 2022
A WNT7B-m6A-TCF7L2 positive feedback loop promotes gastric cancer progression and metastasis., Gao Q, Yang L, Shen A, Li Y, Li Y, Hu S, Yang R, Wang X, Yao X(*), Shen G (*), 2021
ICG-loaded PEG-modified black phosphorus nanosheets for fluorescence imaging-guided breast cancer therapy., Pan W, Chen W, Min Y, Wang J, Yang Z (*), Xu T, Yu F, Shen G (*). Hu Y (*), MA X (*), 2021
The Wnt3a/β-catenin/TCF7L2 signaling axis reduces the sensitivity of HER2-positive epithelial ovarian cancer to trastuzumab., Shen G (#) (*), Gao Q (#), Liu F (#), Zhang Y, Dai M, Zhao T, Cheng M, Xu T, Jin P, Yin W, Huang D, Weng H, Chen W, Ren H, Mu X, Wu X, Hu S(*), 2020

Gastric Cancer Geriatric Tumors Targeted Therapy Sarcopenia Elderly Prevention Tumor-Induced Skeletal Muscle Reduction Mechanism

Feng Shao - University of Science and Technology of China

Wei-Fu Lv - University of Science and Technology of China

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