Professor | Jinwei Zhu | Asia Growth Partners

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Name	Jinwei Zhu
Contact Information	jinwei.zhu@sjtu.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Jinwei Zhu

Contact Information

jinwei.zhu@sjtu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Bio-X Research Institute
Academic Background & Achievements	2005-2010 Doctorate: Fudan University, Chemical Biology 2001-2005 Bachelor's: Nankai University, Chemistry Young Chief Scientist of the Brain Science and Brain-like Research Project Recipient of the National Natural Science Foundation Excellent Young Scientist Fund
Work Experience	2022-present - Shanghai Jiao Tong University Bio-X Institute - Researcher/Tenured Associate Professor, Group Leader 2019-2022 - Shanghai Jiao Tong University Bio-X Institute - Tenure-track Associate Professor, Group Leader 2013-2019 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Associate Researcher 2010-2013 - Hong Kong University of Science and Technology, Department of Life Sciences - Postdoctoral Researcher
Awards	Young Chief Scientist of the Brain Science and Brain-like Research Project Recipient of the National Natural Science Foundation Excellent Young Scientist Fund

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Bio-X Research Institute

Academic Background & Achievements

2005-2010 Doctorate: Fudan University, Chemical Biology
2001-2005 Bachelor's: Nankai University, Chemistry
Young Chief Scientist of the Brain Science and Brain-like Research Project
Recipient of the National Natural Science Foundation Excellent Young Scientist Fund

Work Experience

2022-present - Shanghai Jiao Tong University Bio-X Institute - Researcher/Tenured Associate Professor, Group Leader
2019-2022 - Shanghai Jiao Tong University Bio-X Institute - Tenure-track Associate Professor, Group Leader
2013-2019 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Associate Researcher
2010-2013 - Hong Kong University of Science and Technology, Department of Life Sciences - Postdoctoral Researcher

Awards

Young Chief Scientist of the Brain Science and Brain-like Research Project
Recipient of the National Natural Science Foundation Excellent Young Scientist Fund

Areas of Focus	Molecular mechanisms of synaptic development and signal transduction Structural biology basis of neuropsychiatric diseases
Publications	Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs., Zhang M, Cao A, Lin L, Chen Y, Shang Y, Wang C, Zhang MJ, Zhu J., 2023 Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein-protein interaction inhibitor., Gu J, Peng R, Guo C, Zhang M, Yang J, Yan X, Zhou Q, Li H, Wang N, Zhu J, Ouyang Q., 2022 Polarized condensates confer row identity of hair cell stereocilia., Shi Y, Lin L, Wang C, Zhu J., 2022 Promotion of row 1-specific tip complex condensates by Gpsm2-Gαi provides insights into row identity of the tallest stereocilia., Shi Y, Lin L, Wang C, Zhu J., 2022 Phase Separation of MAGI2-Mediated Complex Underlies Formation of Slit Diaphragm Complex in Glomerular Filtration Barrier., Zhang H, Lin L, Liu J, Pan L, Lin Z, Zhang M, Zhang J, Cao Y, Zhu J, Zhang R., 2021 Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex., Lin L, Shi Y, Wang M, Wang C, Lu Q, Zhu J, Zhang R., 2021 Double inhibition and activation mechanisms of Ephexin family RhoGEFs., Zhang M, Lin L, Wang C, Zhu J., 2021 Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability., Wang M, Lin L, Shi Y, He L, Wang C, Zhu J., 2020 GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling., Zhu J, Zhou Q, Xia Y, Lin L, Li J, Peng M, Zhang R, Zhang M., 2020 Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase., Lin L, Shi Y, Wang M, Wang C, Zhu J, Zhang R., 2019 Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds., Weng Z, Situ C, Lin L, Wu Z, Zhu J, Zhang R., 2019 Structural basis of highly specific interaction between Nephrin and MAGI1 in slit diaphragm assembly and signaling., Weng Z, Shang Y, Ji Z, Ye F, Lin L, Zhang R, Zhu J., 2018 Structural basis of KANK1/KIF21A complex in crosstalk between dynamic microtubule and cell cortex., Weng Z, Shang Y, Yao D, Zhu J, Zhang R., 2018 Synaptic targeting and function of SAPAPs mediated by phosphorylation-dependent binding to PSD-95 MAGUKs., Zhu J, Zhou Q, Shang Y, Peng M, Weng Z, Zhang R, Huang X, Li S, Feng G, Zhang M., 2017 Structure of PSD95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain., Xia Y, Shang Y, Zhang R, Zhu J., 2017 Pins is not required for spindle orientation in the Drosophila wing disc., Bergstralh DT, Lovegrove HE, Kujawiak I, Dawney NS, Zhu J, Cooper S, Zhang R, St Johnston D., 2016 An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B., Zhu J, Shang Y, Xia Y, Zhang R, Zhang M., 2016 Mechanistic Basis of MAGUKs-organized Complexes in Synaptic Development and Signalling., Zhu J, Shang Y, and Zhang M., 2016 Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl., Zhu J, Shang Y, Wan Q, Xia Y, Chen J, Du Q, and Zhang M., 2014 An auto-inhibited conformation of LGN reveals a distinct interaction mode between the GoLoco motifs and TPR motifs., Pan Z, Zhu J, Shang Y, Wei Z, Jia M, Xia C, Wen W, Wang W, Zhang M., 2013 Structure and function of GK domains of MAGUK family proteins., Zhu J, Shang Y, Chen J, Zhang M., 2012 Structure and Biochemical Characterizations of LGN GoLoco/Gαi Interaction Suggest Scaffolding and Gα Signaling Roles of LGN in Asymmetric Cell Division., Jia M, Li J, Zhu J, Wen W, Zhang M, Wang W., 2012 Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein binding modules., Zhu J, Wen W, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q, Wang W, Zhang M., 2011 LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways., Zhu J, Wen W, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q, Wang W, Zhang M., 2011

Areas of Focus

Molecular mechanisms of synaptic development and signal transduction
Structural biology basis of neuropsychiatric diseases

Publications

Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs., Zhang M, Cao A, Lin L, Chen Y, Shang Y, Wang C, Zhang MJ, Zhu J., 2023
Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein-protein interaction inhibitor., Gu J, Peng R, Guo C, Zhang M, Yang J, Yan X, Zhou Q, Li H, Wang N, Zhu J, Ouyang Q., 2022
Polarized condensates confer row identity of hair cell stereocilia., Shi Y, Lin L, Wang C, Zhu J., 2022
Promotion of row 1-specific tip complex condensates by Gpsm2-Gαi provides insights into row identity of the tallest stereocilia., Shi Y, Lin L, Wang C, Zhu J., 2022
Phase Separation of MAGI2-Mediated Complex Underlies Formation of Slit Diaphragm Complex in Glomerular Filtration Barrier., Zhang H, Lin L, Liu J, Pan L, Lin Z, Zhang M, Zhang J, Cao Y, Zhu J, Zhang R., 2021
Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex., Lin L, Shi Y, Wang M, Wang C, Lu Q, Zhu J, Zhang R., 2021
Double inhibition and activation mechanisms of Ephexin family RhoGEFs., Zhang M, Lin L, Wang C, Zhu J., 2021
Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability., Wang M, Lin L, Shi Y, He L, Wang C, Zhu J., 2020
GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling., Zhu J, Zhou Q, Xia Y, Lin L, Li J, Peng M, Zhang R, Zhang M., 2020
Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase., Lin L, Shi Y, Wang M, Wang C, Zhu J, Zhang R., 2019
Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds., Weng Z, Situ C, Lin L, Wu Z, Zhu J, Zhang R., 2019
Structural basis of highly specific interaction between Nephrin and MAGI1 in slit diaphragm assembly and signaling., Weng Z, Shang Y, Ji Z, Ye F, Lin L, Zhang R, Zhu J., 2018
Structural basis of KANK1/KIF21A complex in crosstalk between dynamic microtubule and cell cortex., Weng Z, Shang Y, Yao D, Zhu J, Zhang R., 2018
Synaptic targeting and function of SAPAPs mediated by phosphorylation-dependent binding to PSD-95 MAGUKs., Zhu J, Zhou Q, Shang Y, Peng M, Weng Z, Zhang R, Huang X, Li S, Feng G, Zhang M., 2017
Structure of PSD95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain., Xia Y, Shang Y, Zhang R, Zhu J., 2017
Pins is not required for spindle orientation in the Drosophila wing disc., Bergstralh DT, Lovegrove HE, Kujawiak I, Dawney NS, Zhu J, Cooper S, Zhang R, St Johnston D., 2016
An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B., Zhu J, Shang Y, Xia Y, Zhang R, Zhang M., 2016
Mechanistic Basis of MAGUKs-organized Complexes in Synaptic Development and Signalling., Zhu J, Shang Y, and Zhang M., 2016
Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl., Zhu J, Shang Y, Wan Q, Xia Y, Chen J, Du Q, and Zhang M., 2014
An auto-inhibited conformation of LGN reveals a distinct interaction mode between the GoLoco motifs and TPR motifs., Pan Z, Zhu J, Shang Y, Wei Z, Jia M, Xia C, Wen W, Wang W, Zhang M., 2013
Structure and function of GK domains of MAGUK family proteins., Zhu J, Shang Y, Chen J, Zhang M., 2012
Structure and Biochemical Characterizations of LGN GoLoco/Gαi Interaction Suggest Scaffolding and Gα Signaling Roles of LGN in Asymmetric Cell Division., Jia M, Li J, Zhu J, Wen W, Zhang M, Wang W., 2012
Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein binding modules., Zhu J, Wen W, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q, Wang W, Zhang M., 2011
LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways., Zhu J, Wen W, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q, Wang W, Zhang M., 2011

Synaptic Development Signal Transduction Molecular Mechanisms Neuropsychiatric Diseases Structural Biology Protein Complexes Neural Development Synaptic Signaling Pathological Mechanisms Brain Diseases

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