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Huabing Li
Basic Medical Sciences
Chongqing Medical University
Chongqing
Language: English, Chinese
Rna
Modifications
Epigenetics
Immunity
Immune Cells
Molecular Mechanisms
Pathophysiology
Regulation
Cell Function
Research
Areas of Focus
- RNA Modifications and Epigenetic Immunity
Work Experience
- 2024-present - Chongqing Medical University - Professor
- 2022.3-present - Ruijin Hospital, Shanghai Jiao Tong University School of Medicine - Distinguished Professor
- 2020.5-present - State Key Laboratory of Oncogenes and Related Genes - Principal Investigator
- 2019.5-present - Shanghai Jiao Tong University School of Medicine-Yale University Institute of Immunometabolism - Researcher
- 2017.8-present - Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine - Senior Researcher, Doctoral Supervisor; Yale University School of Medicine - Assistant Professor Adjunct
Academic Background & Achievements
- 2012-2017 Postdoctoral: Yale University
- 2011-2012 Postdoctoral: Rutgers University
- 2005-2011 Ph.D.: Rutgers University
- 2002-2005 M.S.: Nankai University
- 1999-2002 B.S.: Nankai University
- Published in top journals like Nature, Nature Immunology, and Science Advances
Publications
- A Treg specific long non-coding RNA maintains immune-metabolic homeostasis in ageing liver., Ding C, Yu Z, Sefik E, Zhou J, Kaffe E, Wang G, Li B, Flavell RA, Hu W, Ye Y, Li HB, 2023
- tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis., Liu Y, Zhou J, Li X, Zhang X, Shi J, Wang X, Li H, Miao S, Chen H, He X, Dong L, Lee GR, Zhen J, Liu RJ, Su B, Ye Y, Flavell RA, Yi C, Wu Y, Li HB, 2022
- RNA m6A demethylase ALKBH5 regulates the development of γδ T cells., Ding C, Xu H, Yu Z, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W, Flavell R, Li HB, 2022
- DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion., Chen B, Hu J, Chen H, Bao R, Zhou Y, Zhan M, Ye Y, Li H, Li HB, 2022
- m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κb-mediated anti-apoptotic pathway., Zhang T, Ding C, Chen H, Zhao J, Chen J, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M, Flavell RA, Li HB, 2022
- m6A Demethylase ALKBH5 Controls CD4+ T cell Pathogenicity and Promotes Autoimmunity., Zhou J, Zhang X, Hu J, Qu R, Yu Z, Xu H, Chen H, Yan L, Ding C, Zou Q, Ye Y, Wang Z, Flavell RA, Li HB, 2021
- Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation., Tong J, Wang X, Liu Y, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, Zou Q, Zhou Y, Xia Q, Flavell RA, Zhu S, Li HB, 2021
- Cross-talk of Four Types of RNA Modification Writers Defines Tumor Microenvironment and Pharmacogenomic Landscape in Colorectal Cancer., Chen H, Yao J, Bao R, Dong Y, Zhang T, Du Y, Wang G, Ni D, Xun Z, Niu X, Ye Y, Li HB, 2021
- m6A mRNA methylation sustains Treg suppressive functions., Tong J, Cao G, Zhang T, Sefik E, Vesely M, Broughton J, Zhu S, Li H, Li B, Chen L, Chang HY, Su B, Flavell RA, Li HB, 2018
- m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway., Li HB, Tong J, Zhu S, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z, Flavell RA, 2017
Awards
- National Science Fund for Distinguished Young Scholars (2023)
- Shanghai Health Leading Talent (2022)
- National High-level Overseas Talent Youth Project (2018)
- Shanghai 'Oriental Scholar' Distinguished Professor (2018)
