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Depei Liu
liudp@pumc.edu.cn
English, Chinese
Beijing
Peking Union Medical College
Basic Medical Sciences
  • 1986 - PhD: Peking Union Medical College
  • 1996 - Elected as Academician of the Chinese Academy of Engineering
  • 2008 - Elected as Academician of the Institute of Medicine (IOM) and the Third World Academy of Sciences (TWAS)
  • 2016 - Elected as Co-Chair of the International Academy of Medical Sciences (IAPH)
  • 1987-1990 - University of California, San Francisco - Postdoctoral Researcher
  • 1990-present - Peking Union Medical College - Researcher
  • 1991 - Title of 'Outstanding Contributor to Chinese Doctoral Degree Holders'
  • 1993 - 'First National Young and Middle-aged Medical Science and Technology Star'
  • 1994 - 'National Young and Middle-aged Expert with Outstanding Contributions'
  • 1995 - 'Outstanding Young Scientist Fund' by the National Natural Science Foundation of China
  • 1996 - 'Outstanding Young Scholar' by the Qiu Shi Foundation
Gene Expression Regulation and Gene Therapy
Cardiovascular Disease Mechanisms
  • Calorie restriction protects against experimental abdominal aortic aneurysms in mice., Liu Y, Wang TT, Zhang R, Fu WY, Wang X, Wang F, Gao P, Ding YN, Xie Y, Hao DL, Chen HZ, Liu DP., 2016
  • Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm., Chen HZ, Wang F, Gao P, Pei JF, Liu Y, Xu TT, Tang X, Fu WY, Lu J, Yan YF, Wang XM, Han L, Zhang ZQ, Zhang R, Zou MH, Liu DP., 2016
  • The Four Layers of Aging., Zhang R, Chen HZ, Liu DP., 2015
  • Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity., Luo YX, Tang X, An XZ, Xie XM, Chen XF, Zhao X, Hao DL, Chen HZ, Liu DP., 2016
  • Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice., Zhang ZQ, Ren SC, Tan Y, Li ZZ, Tang X, Wang TT, Hao DL, Zhao X, Chen HZ, Liu DP., 2016
  • Both TALENs and CRISPR/Cas9 directly target the HBB IVS2-654 (C > T) mutation in beta-thalassemia-derived iPSCs., Xu P, Tong Y, Liu XZ, Wang TT, Cheng L, Wang BY, Lv X, Huang Y, Liu DP., 2015
  • Sox2 Deacetylation by Sirt1 Is Involved in Mouse Somatic Reprogramming., Mu WL, Wang YJ, Xu P, Hao DL, Liu XZ, Wang TT, Chen F, Chen HZ, Lv X, Liu DP., 2015
  • Interferon regulatory factor 9 is critical for neointima formation following vascular injury., Zhang SM, Zhu LH, Chen HZ, Zhang R, Zhang P, Jiang DS, Gao L, Tian S, Wang L, Zhang Y, Wang PX, Zhang XF, Zhang XD, Liu DP, Li H., 2014
  • A critical role for interferon regulatory factor 9 in cerebral ischemic stroke., Chen HZ, Guo S, Li ZZ, Lu Y, Jiang DS, Zhang R, Lei H, Gao L, Zhang X, Zhang Y, Wang L, Zhu LH, Xiang M, Zhou Y, Wan Q, Dong H, Liu DP, Li H., 2014
  • Interferon regulatory factor 9 is a key mediator of hepatic ischemia/reperfusion injury., Wang PX, Zhang R, Huang L, Zhu LH, Jiang DS, Chen HZ, Zhang Y, Tian S, Zhang XF, Zhang XD, Liu DP, Li H., 2015
  • SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence., Wan YZ, Gao P, Zhou S, Zhang ZQ, Hao DL, Lian LS, Li YJ, Chen HZ, Liu DP., 2014
  • PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1., Wu J, Zhou LQ, Yu W, Zhao ZG, Xie XM, Wang WT, Xiong J, Li M, Xue Z, Wang X, Zhang P, Mao BB, Hao DL, Lv X, Liu DP., 2014
  • Cross-talk between SIRT1 and p66Shc in vascular diseases., Chen HZ, Wan YZ, Liu DP., 2013
  • SIRT1 deacetylates SATB1 to facilitate MAR HS2-MAR epsilon interaction and promote epsilon-globin expression., Xue Z, Lv X, Song W, Wang X, Zhao GN, Wang WT, Xiong J, Mao BB, Yu W, Yang B, Wu J, Zhou LQ, Hao DL, Dong WJ, Liu DP, Liang CC., 2012
  • Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction., Zhou S, Chen HZ, Wan YZ, Zhang QJ, Wei YS, Huang S, Liu JJ, Lu YB, Zhang ZQ, Yang RF, Zhang R, Cai H, Liu DP, Liang CC., 2011
  • Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin., Lu L, Li L, Lv X, Wu XS, Liu DP, Liang CC., 2011
  • SIRT1 acts as a modulator of neointima formation following vascular injury in mice., Li L, Zhang HN, Chen HZ, Gao P, Zhu LH, Li HL, Lv X, Zhang QJ, Zhang R, Wang Z, She ZG, Wei YS, Du GH, Liu DP, Liang CC., 2011
  • Positive regulation of hepatic miR-122 expression by HNF4alpha., Li ZY, Xi Y, Zhu WN, Zeng C, Zhang ZQ, Guo ZC, Hao DL, Liu G, Feng L, Chen HZ, Chen F, Lv X, Liu DP, Liang CC., 2011
  • Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice., Zhuo ML, Huang Y, Chen JZ, Sun LH, Yang RF, Chen HZ, Lv X, Li HL, Wei YS, Liu G, Zhang R, Ma TM, Cai H, Hui RT, Liu DP, Liang CC., 2009
  • Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice., She ZG, Zheng W, Wei YS, Chen HZ, Wang AB, Li HL, Liu G, Zhang R, Liu JJ, Stallcup WB, Zhou Z, Liu DP, Liang CC., 2009
  • Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice., Zhang QJ, Wang Z, Chen HZ, Zhou S, Zheng W, Liu G, Wei YS, Cai H, Liu DP, Liang CC., 2008
  • Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction., Li HL, Zhuo ML, Wang D, Wang AB, Cai H, Sun LH, Yang Q, Huang Y, Wei YS, Liu PP, Liu DP, Liang CC., 2007
  • Chromatin domain boundaries: insulators and beyond., Wei GH, Liu DP, Liang CC., 2005
  • Increased efficiency of oligonucleotide-mediated gene repair through slowing replication fork progression., Wu XS, Xin L, Yin WX, Shang XY, Lu L, Watt RM, Cheah KS, Huang JD, Liu DP, Liang CC., 2005
  • MicroRNAs: key participants in gene regulatory networks., Ke XS, Liu CM, Liu DP, Liang CC., 2003
  • A hypothesis for chromatin domain opening., Xin L, Liu DP, Ling CC., 2003
Gene Expression Gene Therapy Cardiovascular Disease Mechanism Regulation Enhancer Transgenic Model Chromatin Sirtuin Atherosclerosis

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