Professor | Jianmin Zhang | Asia Growth Partners

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Name	Jianmin Zhang
Language ability	English, Chinese
Province	Beijing

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Name

Jianmin Zhang

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Peking Union Medical College
Faculty	Basic Medical Sciences
Academic Background & Achievements	PhD in Immunology: Peking Union Medical College Postdoctoral Research: Yale University and Johns Hopkins University Published over 200 papers in journals like Cell, Nat Immunol, PNAS
Work Experience	Current - Chinese Academy of Medical Sciences/Peking Union Medical College - Professor Previous - Yale University - Postdoctoral Researcher Previous - Johns Hopkins University - Lecturer, Assistant Professor
Awards	National Science and Technology Progress Award Second Prize: 2 times Provincial and Ministerial Science and Technology Progress Award: 1 time

University/Lab Affiliation and Title

Peking Union Medical College

Faculty

Basic Medical Sciences

Academic Background & Achievements

PhD in Immunology: Peking Union Medical College
Postdoctoral Research: Yale University and Johns Hopkins University
Published over 200 papers in journals like Cell, Nat Immunol, PNAS

Work Experience

Current - Chinese Academy of Medical Sciences/Peking Union Medical College - Professor
Previous - Yale University - Postdoctoral Researcher
Previous - Johns Hopkins University - Lecturer, Assistant Professor

Awards

National Science and Technology Progress Award Second Prize: 2 times
Provincial and Ministerial Science and Technology Progress Award: 1 time

Areas of Focus	Role of γδT cells in tumor immune surveillance and application in anti-tumor immunotherapy Pathological mechanisms of neurodegenerative diseases and interaction between nervous and immune systems Directed differentiation of induced pluripotent stem cells and modification of stem cell exosomes
Publications	Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis., Wang W, Xu Y, Wang L, Zhu Z, Aodeng S, Chen H, Cai M, Huang Z, Han J, Wang L, Lin Y, Hu Y, Zhou L, Wang X, Zha Y, Jiang W, Gao Z, He W, Lv W, Zhang J., 2022 Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function., Wang H, Chen H, Liu S, Zhang J, Lu H, Somasundaram R, Choi R, Zhang G, Ou L, Scholler J, Tian S, Dong L, Yeye G, Huang L, Connelly T, Li L, Huang A, Mitchell TC, Fan Y, June CH, Mills GB, Guo W, Herlyn M, Xu X., 2021 The role of microRNAs in γδ T cells: a long way to go., Chen H, Zhang J, He W., 2021 Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome., You H, Dang G, Lu B, Zhang S, Li C, Wang L, Hu Y, Chen H, Zhang J, He W., 2021 TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma., Fu Y, Wang D, Wang H, Cai M, Li C, Zhang X, Chen H, Hu Y, Zhang X, Ying M, He W, Zhang J., 2020 miR-125b-5p and miR-99a-5p downregulate human γδ T-cell activation and cytotoxicity., Zhu Y, Zhang S, Li Z, Wang H, Li Z, Hu Y, Chen H, Zhang X, Cui L, Zhang J, He W., 2019 Profiling the pattern of the human T-cell receptor γδ complementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis., Chen H, Zou M, Teng D, Hu Y, Zhang J, He W., 2019 Human regulatory γδT cells and their functional plasticity in the tumor microenvironment., Chen H, He W., 2018 Chemotaxis of Vδ2 T cells to the joints contributes to the pathogenesis of rheumatoid arthritis., Mo WX, Yin SS, Chen H, Zhou C, Zhou JX, Zhao LD, Fei YY, Yang HX, Guo JB, Mao YJ, Huang LF, Zheng WJ, Zhang W, Zhang JM, He W, Zhang X., 2017 A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells., Mao Y, Yin S, Zhang J, Hu Y, Huang B, Cui L, Kang N, He W., 2016 Distortion of memory Vδ2 γδ T cells contributes to immune dysfunction in chronic HIV infection., Li Z, Jiao Y, Hu Y, Cui L, Chen D, Wu H, Zhang J, He W., 2015 A novel antibody-like TCRγδ-Ig fusion protein exhibits antitumor activity against human ovarian carcinoma., Zheng J, Guo Y, Ji X, Cui L, He W., 2013 Ectopically expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human γδ T cells to induce innate anti-tumor/virus immunity., Dai Y, Chen H, Mo C, Cui L, He W., 2012 Ectopic expression of human MutS homologue 2 on renal carcinoma cells is induced by oxidative stress with interleukin-18 promotion via p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways., Mo C, Dai Y, Kang N, Cui L, He W., 2012 The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior., Zhang J, Wang Y, Chi Z, Keuss MJ, Pai YM, Kang HC, Shin JH, Bugayenko A, Wang H, Xiong Y, Pletnikov MV, Mattson MP, Dawson TM, Dawson VL., 2011 Generation of human regulatory gammadelta T cells by TCRgammadelta stimulation in the presence of TGF-beta and their involvement in the pathogenesis of systemic lupus erythematosus., Li X, Kang N, Zhang X, Dong X, Wei W, Cui L, Ba D, He W., 2011 Tandem-epitope peptide: a novel stimulator for gammadeltaT cells in tumor immunotherapy., He X, Chen H, Wu D, Cui L, He W., 2010 The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D., Kong Y, Cao W, Xi X, Ma C, Cui L, He W., 2009 Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development., Yu M, Wan M, Zhang J, Wu J, Khatri R, Chi T., 2008

Areas of Focus

Role of γδT cells in tumor immune surveillance and application in anti-tumor immunotherapy
Pathological mechanisms of neurodegenerative diseases and interaction between nervous and immune systems
Directed differentiation of induced pluripotent stem cells and modification of stem cell exosomes

Publications

Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis., Wang W, Xu Y, Wang L, Zhu Z, Aodeng S, Chen H, Cai M, Huang Z, Han J, Wang L, Lin Y, Hu Y, Zhou L, Wang X, Zha Y, Jiang W, Gao Z, He W, Lv W, Zhang J., 2022
Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function., Wang H, Chen H, Liu S, Zhang J, Lu H, Somasundaram R, Choi R, Zhang G, Ou L, Scholler J, Tian S, Dong L, Yeye G, Huang L, Connelly T, Li L, Huang A, Mitchell TC, Fan Y, June CH, Mills GB, Guo W, Herlyn M, Xu X., 2021
The role of microRNAs in γδ T cells: a long way to go., Chen H, Zhang J, He W., 2021
Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome., You H, Dang G, Lu B, Zhang S, Li C, Wang L, Hu Y, Chen H, Zhang J, He W., 2021
TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma., Fu Y, Wang D, Wang H, Cai M, Li C, Zhang X, Chen H, Hu Y, Zhang X, Ying M, He W, Zhang J., 2020
miR-125b-5p and miR-99a-5p downregulate human γδ T-cell activation and cytotoxicity., Zhu Y, Zhang S, Li Z, Wang H, Li Z, Hu Y, Chen H, Zhang X, Cui L, Zhang J, He W., 2019
Profiling the pattern of the human T-cell receptor γδ complementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis., Chen H, Zou M, Teng D, Hu Y, Zhang J, He W., 2019
Human regulatory γδT cells and their functional plasticity in the tumor microenvironment., Chen H, He W., 2018
Chemotaxis of Vδ2 T cells to the joints contributes to the pathogenesis of rheumatoid arthritis., Mo WX, Yin SS, Chen H, Zhou C, Zhou JX, Zhao LD, Fei YY, Yang HX, Guo JB, Mao YJ, Huang LF, Zheng WJ, Zhang W, Zhang JM, He W, Zhang X., 2017
A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells., Mao Y, Yin S, Zhang J, Hu Y, Huang B, Cui L, Kang N, He W., 2016
Distortion of memory Vδ2 γδ T cells contributes to immune dysfunction in chronic HIV infection., Li Z, Jiao Y, Hu Y, Cui L, Chen D, Wu H, Zhang J, He W., 2015
A novel antibody-like TCRγδ-Ig fusion protein exhibits antitumor activity against human ovarian carcinoma., Zheng J, Guo Y, Ji X, Cui L, He W., 2013
Ectopically expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human γδ T cells to induce innate anti-tumor/virus immunity., Dai Y, Chen H, Mo C, Cui L, He W., 2012
Ectopic expression of human MutS homologue 2 on renal carcinoma cells is induced by oxidative stress with interleukin-18 promotion via p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways., Mo C, Dai Y, Kang N, Cui L, He W., 2012
The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior., Zhang J, Wang Y, Chi Z, Keuss MJ, Pai YM, Kang HC, Shin JH, Bugayenko A, Wang H, Xiong Y, Pletnikov MV, Mattson MP, Dawson TM, Dawson VL., 2011
Generation of human regulatory gammadelta T cells by TCRgammadelta stimulation in the presence of TGF-beta and their involvement in the pathogenesis of systemic lupus erythematosus., Li X, Kang N, Zhang X, Dong X, Wei W, Cui L, Ba D, He W., 2011
Tandem-epitope peptide: a novel stimulator for gammadeltaT cells in tumor immunotherapy., He X, Chen H, Wu D, Cui L, He W., 2010
The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D., Kong Y, Cao W, Xi X, Ma C, Cui L, He W., 2009
Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development., Yu M, Wan M, Zhang J, Wu J, Khatri R, Chi T., 2008

Γδt Cells Tumor Immune Surveillance Immunotherapy Neurodegenerative Diseases Nervous System Immune System Pluripotent Stem Cells Exosomes Modification

Wang Jinheng - Guangzhou Medical University

Rong Jin - Peking University

Yan Liu - Wuhan University

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