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Pengyu Huang
Biomedical Engineering
Peking Union Medical College
Tianjin
Language: Chinese, English
Bionic Organs
3D Bioprinting
Cell Transplantation
Liver Parenchymal Cells
Lung Stem Cells
Organ Regeneration
Molecular Regulation
Cell Fate
Self-Assembly
Biomedical Engineering
Areas of Focus
- Bionic organ manufacturing and application
- In vitro large-scale expansion and cell transplantation therapy of primary cells such as liver parenchymal cells and lung stem cells
- Research on bionic organ manufacturing based on 3D bioprinting and self-assembly technologies
- Molecular regulatory mechanisms of cell fate determination and transformation during organ regeneration and reconstruction
Work Experience
- 2020.11 – Present - Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Biomedical Engineering - PI, Researcher, Doctoral Supervisor
- 2014.7 – 2020.10 - ShanghaiTech University - PI, Researcher, Doctoral Supervisor
- 2013.9 – 2014.6 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2008.9 – 2013.8 PhD in Cell Biology: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- 2004.9 – 2008.6 Bachelor of Science in Biotechnology, Bachelor of Arts in English: Huazhong University of Science and Technology
- Selected for the Excellent Doctoral Dissertation of the Chinese Academy of Sciences
Publications
- Revitalizing Liver Function in Liver Failure Mice through Transplantation of 3D-Bioprinted Liver with Expanded Primary Hepatocytes, Deng, B., Ma, Y., Huang, J., He, R., Luo, M., Mao, L., Zhang, E., Zhao, Y., Wang, X., Wang, Q., Pang, M., Mao, Y., Yang, H., Liu, L., Huang, P., 2024
- Rapid Self‐Assembly Mini‐Livers Protect Mice Against Severe Hepatectomy-Induced Liver Failure, Luo, M., Lai, J., Zhang, E., Ma, Y., He, R., Mao, L., Deng, B., Zhu, J., Ding, Y., Huang, J., Xue B., Wang, Q., Zhang, M., Huang, P., 2024
- Prediction of Clinical Precision Chemotherapy by Patient‐Derived 3D Bioprinting Models of Colorectal Cancer and Its Liver Metastases, Sun, H., Sun, L., Ke, X., Liu, L., Li, C., Jin, B., Wang, P., Jiang, Z., Zhao, H., Yang, Z., Sun, Y., Liu, J., Wang, Y., Sun, M., Pang, M., Wang, Y., Wu, B., Zhao, H., Sang, X., Xing, B., Yang, H., Huang, P., Mao, Y., 2024
- Mitochondrial genome editing: Get aCcess to modeling broad disease mutations with engineered base editors, Xu, C., Huang, P., 2023
- PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest, Yuan, Y., Wang, C., Zhuang, X., Lin, S., Luo, M., Deng, W., Zhou, J., Liu, L., Mao, L., Peng, W., Chen, J., Wang, Q., Shu, Y., Xue, Y., Huang, P., 2022
- Inhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis, Li, Z., Wang, H., Zhu, J., Nan, N., Lin, Y., Zhuang, X., Li, L., Zhang, Y., Huang, P., 2022
- CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini, Wang, H., Huang R., Li L., Zhu, J., Li, Z., Peng C., Zhuang, X., Lin, H., Shi, S., Huang, P., 2021
- Three-dimensional Bio-printing of primary human hepatocellular carcinoma for personalized medicine, Xie F., Sun L., Pang Y., Xu G., Jin B., Xu H., Lu X., Xu Y., Du S., Wang Y., Feng S., Sang X., Zhong S., Wang X., Sun W., Zhao H., Zhang H., Yang H., Huang P., Mao Y., 2021
- Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure, Yang, H., Sun, L., Pang, Y., Hu, D., Xu, H., Mao, S., Peng, W., Wang, Y., Xu, Y., Zheng, Y., Du, S., Zhao, H., Chi, T., Lu, X., Sang, X., Zhong, S., Wang, X., Zhang, H., Huang, P., Sun, W., Mao, Y., 2021
- Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver, He, B., Peng, W., Huang, J., Zhang, H., Zhou, Y., Yang, X., Liu J., Li, Z., Xu, C., Xue M., Yang, H., Huang, P., 2020
- Conversion of Fibroblasts to Hepatocytes In Vitro, Huang, P., Sun, L., Zhang,L., Hui, L., 2019
- In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice, Zhou, H., Liu, J., Zhou, C., Gao, N., Rao, Z., Li, H., Hu, X., Li, C., Yao, X., Shen, X., Sun, Y., Wei, Y., Liu, F., Ying, W., Zhang, J., Tang, C., Zhang, X., Xu, H., Shi, L., Cheng, L., Huang, P., Yang, H., 2018
- CRISPR/Cas9-mediated targeted integration in vivo using a homology-mediated end joining-based strategy, Yao, X., Wang, X., Liu, J., Shi, L., Huang, P., Yang, H., 2018
- 2-Thiophene ethylamine modified hyaluronic acid with its application on hepatocytes culture, Wang, L., Zhou, Y., Dai, J., Jiang, S., Lu, Y., Sun, M., Gong, J., Huang, P., Yao, Y., 2018
- Generation of Hepatocytes by Transdifferentiation, Huang, P., Chen, Q., 2018
- Pericentral hepatocytes produce insulin-like growth factor-2 to promote liver regeneration during selected injuries in mice, Liu, J., Hu, X., Chen, J., Li, X., Wang, L., Wang, B., Peng, W., Yang, C., Li, Z., Chen, Y., Wang, Y., Li, C., Li, X., Yan, F., Wang, Y., Shang, C., Wang, X., Chen, T., Huang, P., 2017
- CRISPR/Cas9-mediated precise targeted integration in vivo using a double cut donor with short homology arms, Yao, X., Wang, X., Liu, J., Hu, X., Shi, L., Shen, X., Ying, W., Sun, X., Wang, X., Huang, P., Yang, H., 2017
- Role of stem cells in the gastrointestinal tract and in the development of cancer, Huang, P., Li, B., Zheng, Y., 2016
- Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, Shi, X., Gao, Y., Yan, Y., Ma, H., Sun, L., Huang, P., Ni, X., Zhang, L., Zhao, X., Ren, H., Hu, D., Zhou, Y., Tian, F., Ji, Y., Cheng, X., Pan, G., Ding, Y., Hui, L., 2016
- Direct reprogramming of human fibroblasts to functional and expandable hepatocytes, Huang, P., Zhang, L., Gao, Y., He, Z., Yao, D., Wu, Z., Cen, J., Chen, X., Liu, C., Hu, Y., Lai, D., Hu, Z., Chen, L., Zhang, Y., Ma, X., Pan, G., Wang, X., Hui, L., 2014
- Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors, Huang, P., He, Z., Ji, S., Sun, H., Xiang, D., Liu, C., Hu, Y., Wang, X., and Hui, L., 2011
- MAPK signaling in inflammation-associated cancer development, Huang, P., Han, J., and Hui, L., 2010
Awards
- 2021 Tianjin Distinguished Young Scholar: Tianjin Science and Technology Bureau
- 2019 Shanghai Natural Science First Prize (2/5): Shanghai Municipal Government
- 2017 Shanghai Young Top Talent: Shanghai Municipal Party Committee Organization Department
- 2015 Excellent Youth Fund: National Natural Science Foundation of China
- Chinese Academy of Sciences Excellent Doctoral Dissertation: University of Chinese Academy of Sciences
- 2013 JSPS HOPE Fellow: Japan Society for the Promotion of Science (JSPS)
- 2012 Wu Rui Award: Wu Rui Foundation
- 2011 Chinese Academy of Sciences President's Special Award: Chinese Academy of Sciences
