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Pengyu Huang
Biomedical Engineering
Peking Union Medical College
Tianjin
Language: Chinese, English
Hepatocytes
Lung Stem Cells
Cell Transplantation
3D Bioprinting
Bioartificial Organs
Organ Failure
Liver Regeneration
Lung Regeneration
Iron Ion Regulation
Small Rna Regulation
Areas of Focus
- In vitro large-scale expansion and cell transplantation therapy of primary cells such as hepatocytes and lung stem cells
- Construction of bioartificial organs (liver, lung, etc.) using 3D bioprinting and self-assembly technologies, and transplantation therapy for organ failure in animals
- Regulatory mechanisms of liver and lung regeneration, focusing on iron ion regulation and small RNA regulation
Work Experience
- 2020.11 – Present - Chinese Academy of Medical Sciences, Peking Union Medical College, Institute of Biomedical Engineering - Researcher, Doctoral Supervisor
- 2014.7 – 2020.10 - ShanghaiTech University - PI, Researcher, Doctoral Supervisor
- 2013.9 – 2014.6 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2008.9 – 2013.8 Doctorate in Cell Biology: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- 2004.9 – 2008.6 Bachelor of Science in Biotechnology, Bachelor of Arts in English: Huazhong University of Science and Technology
- Selected for the Outstanding Doctoral Dissertation of the Chinese Academy of Sciences
Publications
- PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest, Yuan, Y., Wang, C., Zhuang, X., Lin, S., Luo, M., Deng, W., Zhou, J., Liu, L., Mao, L., Peng, W., Chen, J., Wang, Q., Shu, Y., Xue, Y., Huang, P., 2022
- Inhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis, Li, Z., Wang, H., Zhu, J., Nan, N., Lin, Y., Zhuang, X., Li, L., Zhang, Y., Huang, P., 2022
- CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini, Wang, H., Huang R., Li L., Zhu, J., Li, Z., Peng C., Zhuang, X., Lin, H., Shi, S., Huang, P., 2021
- Three-dimensional Bio-printing of primary human hepatocellular carcinoma for personalized medicine, Xie F., Sun L., Pang Y., Xu G., Jin B., Xu H., Lu X., Xu Y., Du S., Wang Y., Feng S., Sang X., Zhong S., Wang X., Sun W., Zhao H., Zhang H., Yang H., Huang P., Mao Y., 2021
- Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure, Yang, H., Sun, L., Pang, Y., Hu, D., Xu, H., Mao, S., Peng, W., Wang, Y., Xu, Y., Zheng, Y., Du, S., Zhao, H., Chi, T., Lu, X., Sang, X., Zhong, S., Wang, X., Zhang, H., Huang, P., Sun, W., Mao, Y., 2021
- Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver, He, B., Peng, W., Huang, J., Zhang, H., Zhou, Y., Yang, X., Liu J., Li, Z., Xu, C., Xue M., Yang, H., Huang, P., 2020
- Conversion of Fibroblasts to Hepatocytes In Vitro, Huang, P., Sun, L., Zhang,L., Hui, L., 2019
- In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice, Zhou, H., Liu, J., Zhou, C., Gao, N., Rao, Z., Li, H., Hu, X., Li, C., Yao, X., Shen, X., Sun, Y., Wei, Y., Liu, F., Ying, W., Zhang, J., Tang, C., Zhang, X., Xu, H., Shi, L., Cheng, L., Huang, P., Yang, H., 2018
- CRISPR/Cas9-mediated targeted integration in vivo using a homology-mediated end joining-based strategy, Yao, X., Wang, X., Liu, J., Shi, L., Huang, P., Yang, H., 2018
- 2-Thiophene ethylamine modified hyaluronic acid with its application on hepatocytes culture, Wang, L., Zhou, Y., Dai, J., Jiang, S., Lu, Y., Sun, M., Gong, J., Huang, P., Yao, Y., 2018
- Generation of Hepatocytes by Transdifferentiation, Huang, P., Chen, Q., 2018
- Pericentral hepatocytes produce insulinlike growth factor-2 to promote liver regeneration during selected injuries in mice, Liu, J., Hu, X., Chen, J., Li, X., Wang, L., Wang, B., Peng, W., Yang, C., Li, Z., Chen, Y., Wang, Y., Li, C., Li, X., Yan, F., Wang, Y., Shang, C., Wang, X., Chen, T., Huang, P., 2017
- CRISPR/Cas9-mediated precise targeted integration in vivo using a double cut donor with short homology arms, Yao, X., Wang, X., Liu, J., Hu, X., Shi, L., Shen, X., Ying, W., Sun, X., Wang, X., Huang, P., Yang, H., 2017
- Role of stem cells in the gastrointestinal tract and in the development of cancer, Huang, P., Li, B., Zheng, Y., 2016
- Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, Shi, X., Gao, Y., Yan, Y., Ma, H., Sun, L., Huang, P., Ni, X., Zhang, L., Zhao, X., Ren, H., Hu, D., Zhou, Y., Tian, F., Ji, Y., Cheng, X., Pan, G., Ding, Y., Hui, L., 2016
- Direct reprogramming of human fibroblasts to functional and expandable hepatocytes, Huang, P., Zhang, L., Gao, Y., He, Z., Yao, D., Wu, Z., Cen, J., Chen, X., Liu, C., Hu, Y., Lai, D., Hu, Z., Chen, L., Zhang, Y., Ma, X., Pan, G., Wang, X., Hui, L., 2014
- Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors, Huang, P., He, Z., Ji, S., Sun, H., Xiang, D., Liu, C., Hu, Y., Wang, X., and Hui, L., 2011
- MAPK signaling in inflammation-associated cancer development, Huang, P., Han, J., and Hui, L., 2010
Awards
- 2021: Tianjin Distinguished Young Scholar, Tianjin Science and Technology Bureau
- 2019: First Prize of Shanghai Natural Science Award (Second Place), Shanghai Municipal Government
- 2017: Shanghai Young Top Talent, Shanghai Municipal Party Committee Organization Department
- 2015: Excellent Youth Fund, National Natural Science Foundation of China
- Chinese Academy of Sciences Outstanding Doctoral Dissertation, Chinese Academy of Sciences University
- 2013: JSPS HOPE Fellow, Japan Society for the Promotion of Science (JSPS)
- 2012: Wu Rui Award, Wu Rui Foundation
- 2011: Special Award of the President of the Chinese Academy of Sciences, Chinese Academy of Sciences
