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Jingchun Guo
Brain Science Research Institute
Fudan University
Shanghai
Language: Chinese, English
Neurodegeneration
Neuroprotection
Metabolism
Molecular Mechanisms
Neurobiology
Diabetes
Brain Aging
Nrsf/Rest
Autophagy
Lipid Metabolism
Areas of Focus
- Molecular mechanisms of metabolism-related neurodegeneration and neuroprotection
Academic Background & Achievements
- 2005 - PhD: Fudan University
- Achievement: Conducted significant research in neurobiology, focusing on molecular mechanisms of neurodegeneration and neuroprotection.
Publications
- High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression., Xue WJ, He CF, Zhou RY, Xu XD, Xiang LX, Wang JT, Wang XR, Zhou HG, Guo JC, 2022
- Knockdown of NRSF Alleviates Ischemic Brain Injury and Microvasculature Defects in Diabetic MCAO Mice., He CF, Xue WJ, Xu XD, Wang JT, Wang XR, Feng Y, Zhou HG, Guo JC, 2022
- 9-PAHSA Improves Cardiovascular Complications by Promoting Autophagic Flux and Reducing Myocardial Hypertrophy in Db/Db Mice., Wang YM, Mi SL, Jin H, Guo QL, Yu ZY, Wang JT, Zhang XM, Zhang Q, Wang NN, Huang YY, Zhou HG, Guo JC, 2021
- A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy., Wang JT, Yu ZY, Tao YH, Liu YC, Wang YM, Guo QL, Xue JZ, Wen XH, Zhang Q, Xu XD, He CF, Xue WJ, Guo JC, Zhou HG, 2021
- Increased NRSF/REST in anterior cingulate cortex contributes to diabetes-related neuropathic pain., Xu XD, Wen XH, He CF, Yu ZY, Wang JT, Zhou HG, Guo JC, 2020
